Biomimetic cardiovascular stents for in vivo re-endothelialization

Liang, Chunyong; Hu, Yuecheng; Wang, Hongshui; Xia, Dan; Li, Qiang; Zhang, Jiao; Yang, Jianjun; Li, Baoe; Li, Haipeng; Han, Dong; Dong, Mingdong

doi:10.1016/j.biomaterials.2016.06.042

Cited by 94 publications

(50 citation statements)

References 52 publications

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“…The in vivo implantation demonstrated that these stents could match the morphology of SMCs well, which ultimately accelerated re-endothelialization. [157] It has been investigated that cell-like tiny struts (e.g., square and rectangular wells) can promote cell migration and alignment. The cells usually oriented along the long axis of the rectangle.…”

Section: Surface Patternsmentioning

confidence: 99%

Surface Engineering of Cardiovascular Devices for Improved Hemocompatibility and Rapid Endothelialization

Zhao

Feng

2020

Adv Healthcare Materials

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Cardiovascular devices have been widely applied in the clinical treatment of cardiovascular diseases. However, poor hemocompatibility and slow endothelialization on their surface still exist. Numerous surface engineering strategies have mainly sought to modify the device surface through physical, chemical, and biological approaches to improve surface hemocompatibility and endothelialization. The alteration of physical characteristics and pattern topographies brings some hopeful outcomes and plays a notable role in this respect. The chemical and biological approaches can provide potential signs of success in the endothelialization of vascular device surfaces. They usually involve therapeutic drugs, specific peptides, adhesive proteins, antibodies, growth factors and nitric oxide (NO) donors. The gene engineering can enhance the proliferation, growth, and migration of vascular cells, thus boosting the endothelialization. In this review, the surface engineering strategies are highlighted and summarized to improve hemocompatibility and rapid endothelialization on the cardiovascular devices. The potential outlook is also briefly discussed to help guide endothelialization strategies and inspire further innovations. It is hoped that this review can assist with the surface engineering of cardiovascular devices and promote future advancements in this emerging research field.

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Section: Surface Patternsmentioning

confidence: 99%

Surface Engineering of Cardiovascular Devices for Improved Hemocompatibility and Rapid Endothelialization

Zhao

Feng

2020

Adv Healthcare Materials

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“…Vorobyev [79,82~85] 优势 [94] , 可以在多种表面上制造有序的周期性微纳米结构 [95,96] . ; the enlarged region between endothelium and vascular smooth muscle in circumstance of (e) primitive blood vessels, (f) NTS-implanted blood vessels and (g) LTS-implanted blood vessels; tissue adhesion to the (h) normal electrode substrate (i) biomimetic electrode and (j) coupled biomimetic electrode; the SEM images of the surface of (k) normal electrode substrate and (l) coupled biomimetic electrode substrate [92,93] 评述 Han等人 [93] In natural selection, "survival of the fittest" is the prevailing mechanism where organisms have constantly been evolving to adapt themselves to their surroundings. Over billions of years, this evolution process has led to the amazing diversity of biological surfaces with distinctive hierarchical structures and functionality in different organisms.…”

Section: 超疏水性表面mentioning

confidence: 99%

Laser-induced structured biomimetic surface

Han¹,

Zhang²,

Qu³

2018

Chin. Sci. Bull.

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“…Additionally, the morphology of the SMCs well in the vessel wall has been considered to promote the adhesion, proliferation, and migration of ECs, and the scales of the SMCs in a natural blood vessel were measured by AFM to design the surface‐patterned intravascular endoprosthetic stents in Liang et al's research: Their data revealed that the bionic surface patterns on the stents matched the morphology of the SMCs well, which promoted the adhesion, proliferation, and migration of ECs, suggesting significantly enhancement on re‐endothelialization.…”

Section: In Situ Constructing Vascular Endothelial Growth Microenviromentioning

confidence: 99%

Engineering Cardiovascular Implant Surfaces to Create a Vascular Endothelial Growth Microenvironment

Zhang

Huang

2017

Biotechnology Journal

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Cardiovascular disease (CVD) is generally accepted as the leading cause of morbidity and mortality worldwide, and an increasing number of patients suffer from atherosclerosis and thrombosis annually. To treat these disorders and prolong the sufferers' life, several cardiovascular implants have been developed and applied clinically. Nevertheless, thrombosis and hyperplasia at the site of cardiovascular implants are recognized as long-term problems in the practice of interventional cardiology. Here, we start this review from the clinical requirement of the implants, such as anti-hyperplasia, anti-thrombosis, and pro-endothelialization, wherein particularly focus on the natural factors which influence functional endothelialization in situ, including the healthy smooth muscle cells (SMCs) environment, blood flow shear stress (BFSS), and the extracellular matrix (ECM) microenvironment. Then, the currently available strategies on surface modification of cardiovascular biomaterials to create vascular endothelial growth microenvironment are introduced as the main topic, e.g., BFSS effect simulation by surface micro-patterning, ECM rational construction and SMCs phenotype maintain. Finally, the prospects for extending use of the in situ construction of endothelial cells growth microenvironment are discussed and summarized in designing the next generation of vascular implants.

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Biomimetic cardiovascular stents for in vivo re-endothelialization

Cited by 94 publications

References 52 publications

Surface Engineering of Cardiovascular Devices for Improved Hemocompatibility and Rapid Endothelialization

Surface Engineering of Cardiovascular Devices for Improved Hemocompatibility and Rapid Endothelialization

Laser-induced structured biomimetic surface

Engineering Cardiovascular Implant Surfaces to Create a Vascular Endothelial Growth Microenvironment

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