Biomimetic cell membrane-coated nanocarriers for targeted siRNA delivery in cancer therapy

Huang, Xin; Guo, Haoyu; Wang, Lutong; Zhang, Zhicai; Zhang, Weiyue

doi:10.1016/j.drudis.2023.103514

Cited by 23 publications

(9 citation statements)

References 83 publications

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“…69 However, siRNA delivery nanocarriers may stimulate immune responses and cause off-target adverse effects, which can be mitigated using redundancy or chemical conversion of siRNA, as well as predictive bioinformatic methods to reduce off-target effects. 70…”

Section: Rnai Therapeuticsmentioning

confidence: 99%

A biomimetic camouflaged metal organic framework for enhanced siRNA delivery in the tumor environment

Tao,

Rehman,

et al. 2024

J. Mater. Chem. B

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Section: Rnai Therapeuticsmentioning

confidence: 99%

A biomimetic camouflaged metal organic framework for enhanced siRNA delivery in the tumor environment

Tao,

Rehman,

et al. 2024

J. Mater. Chem. B

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“…Therefore, the gene delivery approach based on MBNPs is the key to expanding the application of gene silencing technology in tumor therapy. The parent membrane sources, including CCMs, RCMs, SCMs, PMs, EMs, BMs, and HMs, are summarized as follows ( Wang et al, 2020b ; Huang et al, 2023b ).…”

Section: Application Of Mbnpsmentioning

confidence: 99%

Biomembrane-wrapped gene delivery nanoparticles for cancer therapy

Li,

Zeng,

et al. 2023

Front. Bioeng. Biotechnol.

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As a promising strategy, gene delivery for cancer treatment accepts encouraging progress due to its high efficacy, low toxicity, and exclusive selectivity. However, the delivery efficiency, specific biological distribution, targeted uptake, and biosafety of naked nucleic acid agents still face serious challenges, which limit further clinical application. To overcome the above bottleneck, safe and efficient functional nanovectors are developed to improve the delivery efficiency of nucleic acid agents. In recent years, emerging membrane-wrapped biomimetic nanoparticles (MBNPs) based on the concept of “imitating nature” are well known for their advantages, such as low immunogenicity and long cycle time, and especially play a crucial role in improving the overall efficiency of gene delivery and reducing adverse reactions. Therefore, combining MBNPs and gene delivery is an effective strategy to enhance tumor treatment efficiency. This review presents the mechanism of gene therapy and the current obstacles to gene delivery. Remarkably, the latest development of gene delivery MBNPs and the strategies to overcome these obstacles are summarized. Finally, the future challenges and prospects of gene delivery MBNPs toward clinical transformation are introduced. The principal purpose of this review is to discuss the biomedical potential of gene delivery MBNPs for cancer therapy and to provide guidance for further enhancing the efficiency of tumor gene therapy.

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“…During this process, it is critical to maintain membrane integrity and purity. The higher the membrane integrity and purity, the better the function of the source cells obtained by CMBNDS [ 43 , 44 ]. Therefore, choosing the right extraction and purification method is critical to ensure in vivo safety [ 45 ].…”

Section: Preparation and Characterization Of Cell Membrane Biomimetic...mentioning

confidence: 99%

Cell Membrane Biomimetic Nano-Delivery Systems for Cancer Therapy

Xia,

Mu,

Yuan

et al. 2023

Pharmaceutics

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Nano-delivery systems have demonstrated great promise in the therapy of cancer. However, the therapeutic efficacy of conventional nanomedicines is hindered by the clearance of the blood circulation system and the physiological barriers surrounding the tumor. Inspired by the unique capabilities of cells within the body, such as immune evasion, prolonged circulation, and tumor-targeting, there has been a growing interest in developing cell membrane biomimetic nanomedicine delivery systems. Cell membrane modification on nanoparticle surfaces can prolong circulation time, activate tumor-targeting, and ultimately improve the efficacy of cancer treatment. It shows excellent development potential. This review will focus on the advancements in various cell membrane nano-drug delivery systems for cancer therapy and the obstacles encountered during clinical implementation. It is hoped that such discussions will inspire the development of cell membrane biomimetic nanomedical systems.

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Biomimetic cell membrane-coated nanocarriers for targeted siRNA delivery in cancer therapy

Cited by 23 publications

References 83 publications

A biomimetic camouflaged metal organic framework for enhanced siRNA delivery in the tumor environment

A biomimetic camouflaged metal organic framework for enhanced siRNA delivery in the tumor environment

Biomembrane-wrapped gene delivery nanoparticles for cancer therapy

Cell Membrane Biomimetic Nano-Delivery Systems for Cancer Therapy

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