Biomimetic chitosan-hydroxyapatite hybrid biocoatings for enamel remineralization

Zaharia, Agripina; Muşat, Viorica; Anghel, Elena Maria; Atkinson, Irina; Mocioiu, Oana Cătălina; Bușilă, Mariana; Plescan, Viorica Ghisman

doi:10.1016/j.ceramint.2017.05.346

Cited by 51 publications

(23 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Natural polymers investigated for this application include polysaccharides such as alginate and chitosan, proteins such as collagen, gelatin and silk fibroin, and glycosaminoglycans such as chondroitin sulfate and hyaluronic acid . Chitosan as a highly versatile biomaterial is an osteoconductive, biodegradable and non‐toxic material for the human immune system . Chitosan based scaffolds have drawn considerable attention in tissue engineering and regenerative medicine because they support the attachment and proliferation of osteoblast cells as well as the formation of mineralized bone matrix .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of a novel freeze‐dried silanated chitosan bone tissue engineering scaffold reinforced with electrospun hydroxyapatite nanofiber

Nezafati

Faridi‐Majidi

Pazouki

et al. 2019

Polymer International

View full text Add to dashboard Cite

Novel chitosan scaffolds containing different weight ratios of electrospun hydroxyapatite nanofibers (n-HAs) were fabricated. The fibers possessed diameters in the range 110-170 nm. A fixed concentration of glycidyloxypropyl-trimethoxysilane (GPTMS) as a crosslinking agent was added to the chitosan solution (CG). The porosity percentage was increased when GPTMS and n-HAs were added to the chitosan structure. The presence of GPTMS in the chitosan structure caused a decrease in the average pore size. The pores were more irregular in shape than pure chitosan and CG scaffolds when n-HAs were added. A uniform distribution of n-HAs was seen for a chitosan-GPTMS hybrid scaffold containing 25 wt% n-HAs (CGH25) using energy dispersive X-ray spectroscopy and mapping. The best values of compressive strength and elastic modulus were achieved for CGH25. The swelling ratio was decreased on adding GPTMS to the chitosan scaffold. Different morphologies of hydroxyapatite deposits on the surface of CG and CGH25 (string-like versus needle-like precipitates) were observed after 14 days of soaking in simulated body fluid. For CGH25, the viability of MG-63 osteoblastic cells improved with respect to CG for up to 72 h of cell culture. These results reveal the potential of the chitosan-CGH25 scaffold for use in bone tissue engineering.

show abstract

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of a novel freeze‐dried silanated chitosan bone tissue engineering scaffold reinforced with electrospun hydroxyapatite nanofiber

Nezafati

Faridi‐Majidi

Pazouki

et al. 2019

Polymer International

View full text Add to dashboard Cite

show abstract

“…Chitosan hydrogels formed by gelation can provide homogenous 3D scaffolds with good biocompatibility for cell growth and is promising for bone tissue engineering applications [ 72 ]. Besides, hydrogel is also a common application form of chitosan used to repair dental hard tissues [ 74 , 75 ].…”

Section: Chitosan-based Biomimetically Mineralized Composite Matermentioning

confidence: 99%

“…AS is essential for tooth remineralization, because it supplies calcium and phosphate ions to precipitate HAP. When chitosan-calcium phosphate composites were applied in repairing dental hard tissue, the AS soaking method was usually used [ 74 , 75 ].…”

Section: Chitosan-based Biomimetically Mineralized Composite Matermentioning

confidence: 99%

Chitosan-Based Biomimetically Mineralized Composite Materials in Human Hard Tissue Repair

Ren

et al. 2020

Molecules

View full text Add to dashboard Cite

Chitosan is a natural, biodegradable cationic polysaccharide, which has a similar chemical structure and similar biological behaviors to the components of the extracellular matrix in the biomineralization process of teeth or bone. Its excellent biocompatibility, biodegradability, and polyelectrolyte action make it a suitable organic template, which, combined with biomimetic mineralization technology, can be used to develop organic-inorganic composite materials for hard tissue repair. In recent years, various chitosan-based biomimetic organic-inorganic composite materials have been applied in the field of bone tissue engineering and enamel or dentin biomimetic repair in different forms (hydrogels, fibers, porous scaffolds, microspheres, etc.), and the inorganic components of the composites are usually biogenic minerals, such as hydroxyapatite, other calcium phosphate phases, or silica. These composites have good mechanical properties, biocompatibility, bioactivity, osteogenic potential, and other biological properties and are thus considered as promising novel materials for repairing the defects of hard tissue. This review is mainly focused on the properties and preparations of biomimetically mineralized composite materials using chitosan as an organic template, and the current application of various chitosan-based biomimetically mineralized composite materials in bone tissue engineering and dental hard tissue repair is summarized.

show abstract

“…In order to enhance bone healing process, biocompatibility of hydroxyapatite and excellent mechanical properties of titanium are usually combined to produce versatile bone implants [7,8]. Surface modification of titanium substrate by inorganic mineral coatings could be achieved by applying different techniques such as plasma spraying [9], sol-gel [10], biomimetic process [11], pulsed laser deposition [12] and electrophoretic deposition [13].…”

Section: Introductionmentioning

confidence: 99%

Graphene reinforced hydroxyapatite biocomposite coatings obtained by electrophoretic deposition on titanium

Đošić¹,

Janković²,

Rhee³

et al. 2018

Zaštita materijala

View full text Add to dashboard Cite

Fast ongoing research of graphene-based nanomaterials reveals that their exceptional properties could be utized for biomedical applications, especially in tissue engineering and drug delivery. Here, we summarized the results obtained on hydroxyapatite based biocomposite coatings produced by electrophoretic deposition on titanium substrate and reinforced by nanosized graphene, as potential candidates for hard tissue implants.

show abstract

Biomimetic chitosan-hydroxyapatite hybrid biocoatings for enamel remineralization

Cited by 51 publications

References 44 publications

Synthesis and characterization of a novel freeze‐dried silanated chitosan bone tissue engineering scaffold reinforced with electrospun hydroxyapatite nanofiber

Synthesis and characterization of a novel freeze‐dried silanated chitosan bone tissue engineering scaffold reinforced with electrospun hydroxyapatite nanofiber

Chitosan-Based Biomimetically Mineralized Composite Materials in Human Hard Tissue Repair

Graphene reinforced hydroxyapatite biocomposite coatings obtained by electrophoretic deposition on titanium

Contact Info

Product

Resources

About