Biomimetic composite scaffolds based on surface modification of polydopamine on electrospun poly(lactic acid)/cellulose nanofibrils

Yang, Zhangqiang; Si, Junhui; Cui, Zhixiang; Ye, Jianhua; Wang, Qianting; Peng, Kaiping; Chen, Wenzhe; Chen, Shia‐Chung

doi:10.1016/j.carbpol.2017.07.010

Cited by 78 publications

(27 citation statements)

References 36 publications

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“…However, mechanism of the interactions and accurate structures of PDA had not been confirmed yet . The formed PDA can further incorporate many functional groups, such as phenol, amine, thiol and imine groups . Polymers (or tissues) containing these functional groups can react with PDA via hydrogen bonds and covalent bonds.…”

Section: Introductionmentioning

confidence: 99%

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Fabrication of polydopamine nanoparticles knotted alginate scaffolds and their properties

Jiali

Shi

Dong

et al. 2018

J Biomedical Materials Res

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Polydopamine (PDA) can greatly affect polymer's properties, due to the chemical and physical interactions between the polymers and PDA. In this study, PDA was demonstrated to adjust the pore structures and increase the mechanical properties of alginate hydrogel‐based cartilage tissue scaffolds. Dopamine modified alginate (Alg‐DA) was firstly synthesized by modification of Alg with DA. Alg‐DA interacted with preprepared PDA nanoparticles and further crosslinked with calcium ions (Ca2+) to form the hydrogel scaffold (Alg‐DA/PDA). The Alg‐DA/PDA scaffold combined multiple advantageous features, including continuous pore structure, high level of porosity, well mechanical properties, good biocompatibility and appropriate cycle life of degradation. Moreover, it could provide an optimized forming environment for hydroxyapatite (HAp) by mineralization process, thus accelerating cartilage repair. The improved performances were mainly ascribed to physical enhancement of the PDA nanoparticles and crosslinking points among the polymers and catechol groups in DA. These findings might offer a guideline for fabricating robust biocompatible cartilage tissue scaffold. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 3255–3266, 2018.

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Section: Introductionmentioning

confidence: 99%

“…19 The formed PDA can further incorporate many functional groups, such as phenol, amine, thiol and imine groups. [25][26][27][28] Polymers (or tissues) containing these functional groups can react with PDA via hydrogen bonds and covalent bonds. Therefore, the performance of the composite polymers with PDA were improved largely.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of polydopamine nanoparticles knotted alginate scaffolds and their properties

Jiali

Shi

Dong

et al. 2018

J Biomedical Materials Res

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“…The addition of biological molecules onto the scaffold surface can also enhance the biocompatibility of the biomaterial. Biomimetic scaffolds have been produced from electrospun PLA/CNF composite nanofibres coated in a dopamine solution, to form a layer of poly(dopamine) (PDA) on the surface [ 95 ]. The addition of PDA onto the surface of the scaffold increases the adhesion of hMSCs, due to the large amount of amine and hydroxyl groups present.…”

Section: Methods Of Scaffold Modificationmentioning

confidence: 99%

“…This formed a zwitterionic polymer coating, limiting the fouling on the nanofibre membranes necessary for biomaterials for wound healing or tissue engineering, where antibacterial scaffolds are required. However, a disadvantage to the technique is the deposition of dopamine, which is a very time-consuming process, taking up to several days [ 95 ].…”

Section: Methods Of Scaffold Modificationmentioning

confidence: 99%

Recent Advances in Modified Cellulose for Tissue Culture Applications

2018

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Tissue engineering is a rapidly advancing field in regenerative medicine, with much research directed towards the production of new biomaterial scaffolds with tailored properties to generate functional tissue for specific applications. Recently, principles of sustainability, eco-efficiency and green chemistry have begun to guide the development of a new generation of materials, such as cellulose, as an alternative to conventional polymers based on conversion of fossil carbon (e.g., oil) and finding technologies to reduce the use of animal and human derived biomolecules (e.g., foetal bovine serum). Much of this focus on cellulose is due to it possessing the necessary properties for tissue engineering scaffolds, including biocompatibility, and the relative ease with which its characteristics can be tuned through chemical modification to adjust mechanical properties and to introduce various surface modifications. In addition, the sustainability of producing and manufacturing materials from cellulose, as well as its modest cost, makes cellulose an economically viable feedstock. This review focusses specifically on the use of modified cellulose materials for tissue culturing applications. We will investigate recent techniques used to promote scaffold function through physical, biochemical and chemical scaffold modifications, and describe how these have been utilised to reduce reliance on the addition of matrix ligands such as foetal bovine serum.

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“…PLA has been widely used in the biomedical field owing to its great advantages, which are that it is biodegradable and it does not release any toxic or harmful components [6,11]. However, the surface properties of PLA cannot provide the osteoinductive environment due to its hydrophobic characteristics and poor cell recognition sites [11][12][13]. Therefore, in order to enhance the biocompatibility, the nanofibrous PLA matrix must be coated with a calcium phosphate mineral such as HAp.…”

Section: Introductionmentioning

confidence: 99%

Surface Modification of PLA Nanofibers for Coating with Calcium Phosphate

Suzuki

Nagata

Inagaki

et al. 2018

Trans. Mat. Res. Soc. Japan

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In recent years, three-dimensional scaffolds have attracted great attention due to the development of stem cell tissue engineering. It is expected that the combination of three-dimensional scaffolds and stem cells will be a promising therapy for large defects of tissue such as bone. We have been developing three-dimensional scaffolds by coating poly-lactic acid (PLA) nanofibers with hydroxyapatite (HAp; Ca10(PO4)6(OH)2). Although PLA, a biodegradable polymer, is used in many biomaterials and HAp has great biocompatibility, PLA nanofibers are difficult to coat with HAp due to its hydrophobic property. Calcium phosphate deposition requires hydrophilic groups such as carboxyl groups, which play a key role as calcium phosphate nucleation sites. Hence, in this work, the surface of PLA nanofibers was modified by vacuum ultraviolet (VUV) irradiation or by co-electrospinning with gelatin as a hydrophilic polymer to increase the number of calcium phosphate nucleation sites. The deposition behavior of calcium phosphate on the VUV irradiated PLA nanofibers was facilitated in comparison with the pristine nanofibrous PLA matrices. Therefore, the surface modification via VUV irradiation was an effective way to produce nucleation sites for calcium phosphate deposition.

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Biomimetic composite scaffolds based on surface modification of polydopamine on electrospun poly(lactic acid)/cellulose nanofibrils

Cited by 78 publications

References 36 publications

Fabrication of polydopamine nanoparticles knotted alginate scaffolds and their properties

Fabrication of polydopamine nanoparticles knotted alginate scaffolds and their properties

Recent Advances in Modified Cellulose for Tissue Culture Applications

Surface Modification of PLA Nanofibers for Coating with Calcium Phosphate

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