Biomimetic design of implants for long bone critical-sized defects

Rezapourian, Mansoureh; Kamboj, Nikhil; Jasiuk, Iwona; Hussainova, Irina

doi:10.1016/j.jmbbm.2022.105370

Cited by 21 publications

(9 citation statements)

References 52 publications

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Section: Relevant Bone Properties For the Generation Of Bone Organoidsmentioning

confidence: 99%

“…The periosteum is in contact with the cortical surface of the bone, which thickens during fracture defects, and osteogenic processes occur strongly with periosteal-derived progenitor cells [35,36] (Figure 3C). Bone is divided into cortical bone composed of bone lamella and cancellous bone composed of bone trabeculae [37][38][39][40][41] (Figure 4A,B). As the main site of hematopoiesis, the small blood vessels of the bone marrow pass through the bone in close connection with the surrounding reticulocytes.…”

Section: Key Structures Of the Skeletal Systemmentioning

confidence: 99%

mentioning

confidence: 99%

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A Review of Advanced Biomaterials and Cells for the Production of Bone Organoid

Zhang

et al. 2023

Small Science

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Rapid advancements in traditional bone tissue engineering have led to innovation in bone repair models and the resolution of insurmountable clinical issues like graft scarcity. The pathophysiological process of treating bone disease, however, is a multidimensional and multimodal regenerative regulatory mechanism that includes numerous immune, inflammatory, or metabolic responses related to the graft or the organism itself. Based on a 3D in vitro cell culture system that is remarkably identical to the body's bone tissue, the bone organoid is a biomimicking bone organ environment. It can accurately mimic the actual repair and regeneration condition in vivo because it shares the same physiological function, structure, morphology, and metabolic process as endogenous bone tissue. As a disruptive regenerative medicine technology, it has wide application prospects in the fields of organ development, gene editing, disease modeling, and precision therapy. Herein, the development process and physiological basis of different cell‐based bone organoids are reviewed, the current status of the application of different materials, cells, and construction methods for building bone organoids is described, and the prospects and challenges for the development of bone organoids in future medical fields is discussed.

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Section: Relevant Bone Properties For the Generation Of Bone Organoidsmentioning

confidence: 99%

Section: Key Structures Of the Skeletal Systemmentioning

confidence: 99%

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A Review of Advanced Biomaterials and Cells for the Production of Bone Organoid

Zhang

et al. 2023

Small Science

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“…Investigations of lightweight architectural materials with high load-bearing capacity and controllable deformation mechanism are of great scientific and technological significance in many engineering fields, such as aerospace, [1][2][3] automotive, [4][5][6] medical device, [7][8][9][10] and so on. The uniform periodic lattices built on ordered arrangements of cell unit enable their most extensively applications, due to the controllable density and modifiable size.…”

Section: Introductionmentioning

confidence: 99%

Mechanical Characteristics of Architected Polycrystal Lattice Affected by the Orientation of Metagrain Boundary

Chen

Cui

et al. 2023

Adv Eng Mater

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The orientation of internal metagrain boundary shows an important influence on shearing behaviors and mechanical performance of architected polycrystal lattice. This study designs four types of architected polycrystal lattices equipped with single boundary, multiple parallel boundaries, or multiple intersecting boundaries, with boundary orientations of 0°, 26.55°, 45°, 63.45°, or 90°. The compressive responses of these architected polycrystal lattices are investigated to reveal the effects of the boundary orientations. Especially the relations between the shearing deformation and the boundary orientation are clarified, and the underlying shearing mechanisms are discussed to provide a basis for predicting and explaining the energy absorbing capacity in the architected polycrystal lattice. For the architected polycrystal lattice consisting of +30° and −30° orientated metagrains with intrinsic shear bands of 60° and 75°, the 75° rather than 60° shear band is more likely to occur when the angle of the architected polycrystal boundary increases from 0° to 90°. Most importantly, the higher energy absorption prefers the shear band more horizontal and shorter, which can be realized by increasing the angle and the number of grain boundaries. This contributes to resisting catastrophic failure for lattice structures. These findings provide guidance for developing novel lattice structures with well‐controlled mechanical characteristics.

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“…Metallic biomaterials orchestrate and severe for long periods of time without any significant rejection with the characteristics like high corrosion and wear resistance, suited IOP Publishing doi:10.1088/1757-899X/1296/1/012022 2 mechanical properties for large bone defects, and biocompatibility. However, the several downsides to using metallic biomaterials which include stress shielding [2] of the mangled bone, bioactivity, and Figure 1. The bone hierarchy at the macro, micro, and nano-level, adapted from [3] revision of the surgery at the orthopedic defect.…”

Section: Introductionmentioning

confidence: 99%

Bioinert ceramics scaffolds for bone tissue engineering by laser-based powder bed fusion: a preliminary review

Kamboj,

Piili,

Ganvir

et al. 2023

IOP Conf. Ser.: Mater. Sci. Eng.

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The implementation of laser powder bed fusion (PBF-LB) on ceramics is far more demanding than their metallic and polymeric counterparts for bone tissue engineering (BTE). The review will shed light on bioinert ceramics-based biomaterials manufacturing through PBF-LB incorporating alumina and yttria-stabilized zirconia as oxide-based ceramics and nitride-based ceramics as non-oxide-based ceramics with particular prominence on their properties and requirements for biomedical devices and BTE. The review paper will also classify bioinert scaffolds processed through PBF-LB as a medium to manufacture drug delivery systems (DDS) and to ameliorate critical-sized bone defects based on the fracture site length of the bone with the various modes of functionalization through the incorporation of drugs, stem cells, and growth factors for personalized medicine.

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Biomimetic design of implants for long bone critical-sized defects

Cited by 21 publications

References 52 publications

A Review of Advanced Biomaterials and Cells for the Production of Bone Organoid

A Review of Advanced Biomaterials and Cells for the Production of Bone Organoid

Mechanical Characteristics of Architected Polycrystal Lattice Affected by the Orientation of Metagrain Boundary

Bioinert ceramics scaffolds for bone tissue engineering by laser-based powder bed fusion: a preliminary review

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