Biomimetic DNA nanoballs for oligonucleotide delivery

Kim, Mi‐Gyeong; Park, Joo Yeon; Shim, Gayong; Choi, Han‐Gon; Oh, Yu‐Kyoung

doi:10.1016/j.biomaterials.2015.04.037

Cited by 35 publications

(18 citation statements)

References 30 publications

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“…The polymerase continually adds complementary nucleotides to the template until it is denatured or runs out of available nucleotides. This creates long stranded DNA with a known, repeating sequence that is dependent on the sequence of the circular template . This long stranded DNA can be manipulated through staple strands similarly to DNA origami .…”

Section: Dna‐based Approaches For Drug/gene Deliverymentioning

confidence: 99%

“…The staple strands can also be manufactured through RCA and cleaved through a site‐specific cleavage. RCA has been used to create nanotubes, DNA nanoballs . nanobelts that can intercalate dox and quantum dots, and DNA nanoclews .…”

Section: Dna‐based Approaches For Drug/gene Deliverymentioning

confidence: 99%

“…Kim et al created a DNA nanoball composed of an RCA template that was complimentary and hybridized to two types of antisense oligonucleotides . These were then condensed by cationic Mu peptides and coated with hyaluronic acid to target the CD44 receptors.…”

Section: Dna‐based Approaches For Drug/gene Deliverymentioning

confidence: 99%

“…As a result, some DNA nanostructures, not containing targeting modalities, may need some kind of cationic transfection agent, such as Lipofectamine, to increase the cellular uptake and therapeutic efficacy . Positively charged intercalators or positively charged proteins, such as Dox, viral capsule proteins, or cationic polymers, may also help reduce the net negative charge thus reducing the electrostatic repulsion in the DNA structure itself and between the DNA nanotechnology and the cell membrane …”

Section: Dna‐based Approaches For Drug/gene Deliverymentioning

confidence: 99%

See 3 more Smart Citations

DNA Nanotechnology for Precise Control over Drug Delivery and Gene Therapy

Angell

Xie

Zhang

et al. 2016

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121

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Nanomedicine has been growing exponentially due to its enhanced drug targeting and reduced drug toxicity. It uses the interactions where nanotechnological components and biological systems communicate with each other to facilitate the delivery performance. At this scale, the physiochemical properties of delivery systems strongly affect their capacities. Among current delivery systems, DNA nanotechnology shows many advantages because of its unprecedented engineering abilities. Through molecular recognition, DNA nanotechnology can be used to construct a variety of nanostructures with precisely controllable size, shape, and surface chemistry, which can be appreciated in the delivery process. In this review, different approaches that are currently used for the construction of DNA nanostructures are reported. Further, the utilization of these DNA nanostructures with the well-defined parameters for the precise control in drug delivery and gene therapy is discussed.

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Section: Dna‐based Approaches For Drug/gene Deliverymentioning

confidence: 99%

Section: Dna‐based Approaches For Drug/gene Deliverymentioning

confidence: 99%

Section: Dna‐based Approaches For Drug/gene Deliverymentioning

confidence: 99%

Section: Dna‐based Approaches For Drug/gene Deliverymentioning

confidence: 99%

See 2 more Smart Citations

DNA Nanotechnology for Precise Control over Drug Delivery and Gene Therapy

Angell

Xie

Zhang

et al. 2016

Small

121

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“…employed hybridization with a specific DNA template with a condensation of the resulted DNA complex by a viral Mu peptide (Fig. ) . The formed “DNA nanoballs” coated with HA were effectively internalized by cancer cells.…”

Section: Cell/tissue Targetingmentioning

confidence: 99%

Nanotechnology in Glycomics: Applications in Diagnostics, Therapy, Imaging, and Separation Processes

Dosekova

Filip

Bertók

et al. 2016

Medicinal Research Reviews

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This review comprehensively covers the most recent achievements (from 2013) in the successful integration of nanomaterials in the field of glycomics. The first part of the paper addresses the beneficial properties of nanomaterials for the construction of biosensors, bioanalytical devices, and protocols for the detection of various analytes, including viruses and whole cells, together with their key characteristics. The second part of the review focuses on the application of nanomaterials integrated with glycans for various biomedical applications, that is, vaccines against viral and bacterial infections and cancer cells, as therapeutic agents, for in vivo imaging and nuclear magnetic resonance imaging, and for selective drug delivery. The final part of the review describes various ways in which glycan enrichment can be effectively done using nanomaterials, molecularly imprinted polymers with polymer thickness controlled at the nanoscale, with a subsequent analysis of glycans by mass spectrometry. A short section describing an active glycoprofiling by microengines (microrockets) is covered as well.

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