Biomimetic fabrication bioprinting strategies based on decellularized extracellular matrix for musculoskeletal tissue regeneration: Current status and future perspectives

Liu, Hao; Xing, Fei; Yu, Peiyun; Lu, Rongying; Ma, Shanshan; Shakya, Sujan; Zhou, Xiang; Peng, Kun; Zhang, Dagang; Liu, Ming

doi:10.1016/j.matdes.2024.113072

Materials & Design

2024

DOI: 10.1016/j.matdes.2024.113072

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Biomimetic fabrication bioprinting strategies based on decellularized extracellular matrix for musculoskeletal tissue regeneration: Current status and future perspectives

Hao Liu,

Fei Xing,

Peiyun Yu

et al.

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Cited by 4 publications

References 180 publications

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Development of bioactive solid-foam scaffolds from decellularized cartilage with chondrogenic and osteogenic properties

Mendibil,

Lópiz-Morales,

Arnaiz

et al. 2024

Materials Today Bio

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Development of bioactive solid-foam scaffolds from decellularized cartilage with chondrogenic and osteogenic properties

Mendibil,

Lópiz-Morales,

Arnaiz

et al. 2024

Materials Today Bio

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Technique of 3D printing for scaffolding in tissue engineering of bones: Opportunities and challenges

Jaiswal,

Wadetwar

2025

Materials Today Communications

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Concentration modulated microstructure and rheological properties of nanofibrous hydrogels derived from decellularized human amniotic membrane for 3D cell culture

Kafili,

Tamjid,

Niknejad

et al. 2024

J Mater. Sci: Mater Eng.

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Decellularized amnion (dAM)-derived hydrogels have been extensively exploited for versatile medical and therapeutical applications, particularly for soft tissue engineering of skin, vascular graft, and endometrium. In contrast to polyacrylamide-based hydrogels, which have been extensively employed as a 3D cell culture platform, the cell response of dAM hydrogel is yet to be understood. In this study, we have prepared hydrogels containing different concentrations of dAM and systematically investigated their microstructural features, gelation kinetics, and rheological properties. The results show that dAM hydrogels possess a network of fibers with an average diameter of 56 ± 5 nm at 1% dAM, which increases to 110 ± 14 nm at 3% dAM. The enhanced intermolecular crosslinking between the microfibrillar units increases the gelation rate in the growth phase of the self-assembly process. Moreover, increasing the concentration of dAM in the hydrogel formulation (from 1 to 3%w/v) enhances the dynamic mechanical moduli of the derived hydrogels by about two orders of magnitude (from 41.8 ± 2.5 to 896.2 ± 72.3 Pa). It is shown that the variation in the hydrogel stiffness significantly affects the morphology of dermal fibroblast cells cultured in the hydrogels. It is shown that the hydrogels containing up to 2%w/v dAM provide a suitable microenvironment for embedded fibroblast cells with spindle-like morphology. Nevertheless, at the higher concentration, an adverse effect on the proliferation and morphology of fibroblast cells is noticed due to stiffness-induced phenotype transformation of cells. Concentration-modulated properties of dAM hydrogels offer an in vitro platform to study cell-related responses, disease modeling, and drug studies. Graphical abstract

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Biomimetic fabrication bioprinting strategies based on decellularized extracellular matrix for musculoskeletal tissue regeneration: Current status and future perspectives

Cited by 4 publications

References 180 publications

Development of bioactive solid-foam scaffolds from decellularized cartilage with chondrogenic and osteogenic properties

Development of bioactive solid-foam scaffolds from decellularized cartilage with chondrogenic and osteogenic properties

Technique of 3D printing for scaffolding in tissue engineering of bones: Opportunities and challenges

Concentration modulated microstructure and rheological properties of nanofibrous hydrogels derived from decellularized human amniotic membrane for 3D cell culture

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