Biomimetic fabrication of calcium phosphate/chitosan nanohybrid composite in modified simulated body fluids

Park, K. H.; Kim, S. J.; Hwang, Moon-Jin; Song, Ho Jun; Park, Y. J.

doi:10.3144/expresspolymlett.2017.3

Cited by 27 publications

(10 citation statements)

References 21 publications

(39 reference statements)

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“…This applies both to synthesis methods (mineralization of polymer fibers) and to the first polymers studied, such as collagen (type I and II) and gelatin [13][14][15][16]. Currently, the range of applied polymers significantly expanded-chitosan, starch, polyvinyl alcohol, polycaprolactone and several others have been applied [17][18][19][20]. Blends of natural and synthetic polymers act for a new class of materials with improved mechanical properties and biocompatibility compared to single-component materials [21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Composite Polyvinylpyrrolidone–Sodium Alginate—Hydroxyapatite Hydrogel Films for Bone Repair and Wound Dressings Applications

et al. 2021

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Today, the synthesis of biocompatible and bioresorbable composite materials such as “polymer matrix-mineral constituent,” which stimulate the natural growth of living tissues and the restoration of damaged parts of the body, is one of the challenging problems in regenerative medicine. In this study, composite films of bioresorbable polymers of polyvinylpyrrolidone (PVP) and sodium alginate (SA) with hydroxyapatite (HA) were obtained. HA was introduced by two different methods. In one of them, it was synthesized in situ in a solution of polymer mixture, and in another one, it was added ex situ. Phase composition, microstructure, swelling properties and biocompatibility of films were investigated. The crosslinked composite PVP-SA-HA films exhibit hydrogel swelling characteristics, increasing three times in mass after immersion in a saline solution. It was found that composite PVP-SA-HA hydrogel films containing HA synthesized in situ exhibited acute cytotoxicity, associated with the presence of HA synthesis reaction byproducts—ammonia and ammonium nitrate. On the other hand, the films with HA added ex situ promoted the viability of dental pulp stem cells compared to the films containing only a polymer PVP-SA blend. The developed composite hydrogel films are recommended for such applications, such as membranes in osteoplastic surgery and wound dressing.

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Section: Introductionmentioning

confidence: 99%

Composite Polyvinylpyrrolidone–Sodium Alginate—Hydroxyapatite Hydrogel Films for Bone Repair and Wound Dressings Applications

et al. 2021

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“…These composite materials are uniform and have excellent mechanical and biological properties [ 44 ]. Because of the nearly physiological conditions, without using special equipment or extremely high processing temperature, the latter way also belongs to a biomimetic mineralization technology, which simulates the process of biomineralization [ 47 ]. Biomimetic mineralization technology uses organic molecules (protein, peptide, collagen, polymer, etc.)…”

Section: Chitosan-based Biomimetically Mineralized Composite Matermentioning

confidence: 99%

“…Inspired by the biomineralization process and biomineral components of natural organisms, the inorganic components that form the biomimetically mineralized composite material with chitosan are usually natural biominerals, and the most common are various calcium phosphates (CaP), such as HAP [ 81 , 82 ], ACP [ 65 , 83 ], DCPD [ 44 ], OCP [ 47 ], and other intermediate phases of calcium phosphate [ 84 ]. Silicas [ 85 , 86 ] are also included.…”

Section: Chitosan-based Biomimetically Mineralized Composite Matermentioning

confidence: 99%

“…It generally takes 7–21 days [ 80 , 95 ]. Therefore, to shorten the immersion time, SBF solutions with different ion concentrations and various times were used, such as the 1.5 times SBF (a 1.5 times ionic concentration of SBF) [ 80 ], Modified SBF (a two-fold increase in the concentrations of calcium and phosphate ions, compared to SBF) [ 47 ], and 5 times SBF (a 5 times ionic concentration of SBF) [ 59 , 95 ]. AS is an artificial solution that has a similar composition to that of human saliva, its recipes are varied but Ca 2+ and PO 4 3− are always contained [ 96 ].…”

Section: Chitosan-based Biomimetically Mineralized Composite Matermentioning

confidence: 99%

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Chitosan-Based Biomimetically Mineralized Composite Materials in Human Hard Tissue Repair

Ren

et al. 2020

Molecules

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Chitosan is a natural, biodegradable cationic polysaccharide, which has a similar chemical structure and similar biological behaviors to the components of the extracellular matrix in the biomineralization process of teeth or bone. Its excellent biocompatibility, biodegradability, and polyelectrolyte action make it a suitable organic template, which, combined with biomimetic mineralization technology, can be used to develop organic-inorganic composite materials for hard tissue repair. In recent years, various chitosan-based biomimetic organic-inorganic composite materials have been applied in the field of bone tissue engineering and enamel or dentin biomimetic repair in different forms (hydrogels, fibers, porous scaffolds, microspheres, etc.), and the inorganic components of the composites are usually biogenic minerals, such as hydroxyapatite, other calcium phosphate phases, or silica. These composites have good mechanical properties, biocompatibility, bioactivity, osteogenic potential, and other biological properties and are thus considered as promising novel materials for repairing the defects of hard tissue. This review is mainly focused on the properties and preparations of biomimetically mineralized composite materials using chitosan as an organic template, and the current application of various chitosan-based biomimetically mineralized composite materials in bone tissue engineering and dental hard tissue repair is summarized.

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“…Biomimetic materials are synthetic materials that mimic natural materials or that follow a design motif derived from nature [15][16][17][18]. This nascent field has made significant developments in recent years.…”

Section: Introductionmentioning

confidence: 99%

Bending control of liquid-crystal elastomers based on doped azo derivatives synthesized via controlled gradient polymerization

Fitriyani¹,

Liu²,

Hung³

et al. 2020

Express Polym. Lett.

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The intelligence, complexity, and diversification of nature is a continuous source of inspiration for humankind. Imitating natural intelligence to devise bionic microrobots with self-regulated features remains an enormous challenge. Herein, we demonstrate a biomimetic soft material that uses light to trigger mechanical motion. This light-sensitive mimosa mimetic film was designed based on liquid crystal elastomers (LCEs) and photoisomerizable azo compounds. To control the bending direction, a predesigned UV-induced gradient polymerization was used. The energy-controlled polymerized film comprises one high-density and one low-density liquid crystal mesogen face. Similar to mimosas, the fabricated films achieved stimuli-responsive actuation, exhibiting shape deformation upon light illumination. The elastic network undergoes reversible shape changes via photochemical trans-cis isomerization of an azo compound in response to a stimulus. In this study, only a small amount of photoisomerizable 1-Hydroxy-n-(4-nitro-azobenzene-4′-oxy)hexane (AZO) was used; however, the domino effect caused a significant reversible actuation. The mesogen density of the top and bottom faces was found to be an important factor for the bending control. This study explores a new way to fabricate films that can bend in controlled directions during light irradiation. This phototunable film is expected to be used for applications in microrobotics and micromachinery.

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Biomimetic fabrication of calcium phosphate/chitosan nanohybrid composite in modified simulated body fluids

Cited by 27 publications

References 21 publications

Composite Polyvinylpyrrolidone–Sodium Alginate—Hydroxyapatite Hydrogel Films for Bone Repair and Wound Dressings Applications

Composite Polyvinylpyrrolidone–Sodium Alginate—Hydroxyapatite Hydrogel Films for Bone Repair and Wound Dressings Applications

Chitosan-Based Biomimetically Mineralized Composite Materials in Human Hard Tissue Repair

Bending control of liquid-crystal elastomers based on doped azo derivatives synthesized via controlled gradient polymerization

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