Biomimetic gold nanomaterials for biosensing, bioimaging and biotherapy: a mini-review

Zhu, Danzhu; Zhang, Xiaoting; Han, Yipeng; Luan, Xin; Wei, Gang

doi:10.1039/d2sd00222a

Cited by 10 publications

(6 citation statements)

References 145 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The AuNPs can be broadly classified into two sets depending on their area of application and structure. The first set contains nanoparticles that are coupled with molecules that have different properties, and are applied for bioimaging, biosensors, targeted drug delivery, and localized hyperthermia [ 43 , 44 ]. The next set contains polyfunctional, hollow AuNPs that have a gold shell and magnetic core and are commonly utilized for encapsulating the agents for therapies [ 45 ].…”

Section: Inorganic and Organic Nanoparticlesmentioning

confidence: 99%

Exploration of inorganic nanoparticles for revolutionary drug delivery applications: a critical review

Unnikrishnan,

Joy,

Megha

et al. 2023

Discover Nano

View full text Add to dashboard Cite

The nanosystems for delivering drugs which have evolved with time, are being designed for greater drug efficiency and lesser side-effects, and are also complemented by the advancement of numerous innovative materials. In comparison to the organic nanoparticles, the inorganic nanoparticles are stable, have a wide range of physicochemical, mechanical, magnetic, and optical characteristics, and also have the capability to get modified using some ligands to enrich their attraction towards the molecules at the target site, which makes them appealing for bio-imaging and drug delivery applications. One of the strong benefits of using the inorganic nanoparticles-drug conjugate is the possibility of delivering the drugs to the affected cells locally, thus reducing the side-effects like cytotoxicity, and facilitating a higher efficacy of the therapeutic drug. This review features the direct and indirect effects of such inorganic nanoparticles like gold, silver, graphene-based, hydroxyapatite, iron oxide, ZnO, and CeO2 nanoparticles in developing effective drug carrier systems. This article has remarked the peculiarities of these nanoparticle-based systems in pulmonary, ocular, wound healing, and antibacterial drug deliveries as well as in delivering drugs across Blood–Brain-Barrier (BBB) and acting as agents for cancer theranostics. Additionally, the article sheds light on the plausible modifications that can be carried out on the inorganic nanoparticles, from a researcher’s perspective, which could open a new pathway. Graphical abstract

show abstract

Section: Inorganic and Organic Nanoparticlesmentioning

confidence: 99%

Exploration of inorganic nanoparticles for revolutionary drug delivery applications: a critical review

Unnikrishnan,

Joy,

Megha

et al. 2023

Discover Nano

View full text Add to dashboard Cite

show abstract

“…Researchers are working on developing biosensors that can detect and analyze subtle conditions in individuals using advanced biosensing materials. − Similarly, DNA has become a fascinating material for biosensor engineering due to its essential role in organisms. , A biosensor typically involves a target detection component and a transducer that produces enhanced signals when interacting with target analytes. Developing biosensors that can detect target analytes with a low concentration is a major concern .…”

Section: Introductionmentioning

confidence: 99%

DNA and Nanomaterials: A Functional Combination for DNA Sensing

Quazi,

Choi,

Kim

et al. 2024

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

Recent decades have experienced tough situations due to the lack of reliable diagnostic facilities. The most recent cases occurred during the pandemic, where researchers observed the lack of diagnostic facilities with precision. Microorganisms and viral disease's ability to escape diagnosis has been a global challenge. DNA always has been a unique moiety with a strong and precise base-paired structure. DNA in human and foreign particles makes identification possible through base pairing. Since then, researchers have focused heavily on designing diagnostic assays targeting DNA in particular. Moreover, DNA nanotechnology has contributed vastly to designing composite nanomaterials by combining DNA/nucleic acids with functional nanomaterials and inorganic nanoparticles exploiting their physicochemical properties. These nanomaterials often exhibit unique or enhanced properties due to the synergistic activity of the many components. The capabilities of DNA and additional nanomaterials have shown the combination of robust and advanced tailoring of biosensors. Preceding findings state that the conventional strategies have exhibited certain limitations such as a low range of target detection, less biodegradability, subordinate half-life, and high susceptibility to microenvironments; however, a DNA−nanomaterial-based biosensor has overcome these limitations meaningfully. Additionally, the unique properties of nucleic acids have been studied extensively due to their high signal conduction abilities. Here, we review recent studies on DNA−nanomaterial-based biosensors, their mechanism of action, and improved/updated strategies in vivo and in situ. Furthermore, this review highlights the recent methodologies on DNA utilization to exploit the interfacial properties of nanomaterials in DNA sensing. Lastly, the review concludes with the limitations/challenges and future directions.

show abstract

“…They are considered an interesting signal source for reasons that their photostability, simple transducing principle without sophisticated light source, and versatile embedding protocols in various matrices (polymeric or inorganic) for advanced studies. Therefore, they have already widely applied in many fields such as optical sensors [ 43 , 44 ], biomedical materials [ 45 , 46 ], electronics and even agriculture [ 47 ] and food technology [ 48 ]. All these applications are closely related to their chemical inertness (noble metals) and morphological diversity, which greatly influence their optoelectronics properties [ 49 , 50 , 51 ].…”

Section: Introductionmentioning

confidence: 99%

Pb2+ Ion Sensors Employing Gold Etching Process: Comparative Investigation on Au Nanorods and Au Nanotriangles

Park,

2024

Sensors

View full text Add to dashboard Cite

The leaching phenomenon of gold (Au) nanomaterials by Pb2+ ions in the presence of 2-mercaptoethanol (2-ME) and thiosulfate (S2O32− ion) has been systematically applied to a Pb2+ ion sensor. To further investigate the role of Pb2+ ions in sensors containing Au nanomaterials, we revisited the leaching conditions for Au nanorods and compared them with the results for Au nanotriangles. By monitoring the etching rate, it was revealed that Pb2+ ions were important for the acceleration of the etching rate mainly driven by 2-ME and S2O32− pairs, and nanomolar detection of Pb2+ ions were shown to be promoted through this catalytic effect. Using the etchant, the overall size of the Au nanorods decreased but showed an unusual red-shift in UV-Vis spectrum indicating increase of aspect ratio. Indeed, the length of Au nanorods decreased by 9.4% with the width decreasing by 17.4% over a 30-min reaction time. On the other hand, the Au nanotriangles with both flat sides surrounded mostly by dense Au{111} planes showed ordinary blue-shift in UV-Vis spectrum as the length of one side was reduced by 21.3%. By observing the changes in the two types of Au nanomaterials, we inferred that there was facet-dependent alloy formation with lead, and this difference resulted in Au nanotriangles showing good sensitivity, but lower detection limits compared to the Au nanorods.

show abstract

Biomimetic gold nanomaterials for biosensing, bioimaging and biotherapy: a mini-review

Abstract: Gold nanomaterials (AuNMs) have different morphologies such as nanoparticles (NPs), nanorods (NRs), nanoclusters (NCs), and many others. Due to their unique structures and properties, AuNMs have exhibited broad application prospects...

Cited by 10 publications

References 145 publications

Exploration of inorganic nanoparticles for revolutionary drug delivery applications: a critical review

Exploration of inorganic nanoparticles for revolutionary drug delivery applications: a critical review

DNA and Nanomaterials: A Functional Combination for DNA Sensing

Pb2+ Ion Sensors Employing Gold Etching Process: Comparative Investigation on Au Nanorods and Au Nanotriangles

Contact Info

Product

Resources

About