Biomimetic Gold Nanorods Modified with Erythrocyte Membranes for Imaging-Guided Photothermal/Gene Synergistic Therapy

Guo, Kai; Ren, Shuai; Zhang, Huifeng; Cao, Yingying; Zhao, Yatong; Wang, Yajie; Qiu, Wenli; Tian, Ying; Song, Lina; Wang, Zhongqiu

doi:10.1021/acsami.3c00865

Cited by 8 publications

(2 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a recent study, Guo et al investigated the role of erythrocyte membranes and antibody-modified AuNRs as nanocarriers for improving antitumor effects. Their findings suggest that these nanocarriers may be able to diagnose and treat pancreatic cancer through active targeting [ 114 ]. Chen et al demonstrated superior radiosensitization with albumin-AuNPs compared to AuNPs alone.…”

Section: Research On Polysaccharide-aunps As Drug Delivery Carriersmentioning

confidence: 99%

Research Progress of Polysaccharide-Gold Nanocomplexes in Drug Delivery

Song,

Aipire,

Dilxat

et al. 2024

Pharmaceutics

View full text Add to dashboard Cite

Clinical drug administration aims to deliver drugs efficiently and safely to target tissues, organs, and cells, with the objective of enabling their therapeutic effects. Currently, the main approach to enhance a drug’s effectiveness is ensuring its efficient delivery to the intended site. Due to the fact that there are still various drawbacks of traditional drug delivery methods, such as high toxicity and side effects, insufficient drug specificity, poor targeting, and poor pharmacokinetic performance, nanocarriers have emerged as a promising alternative. Nanocarriers possess significant advantages in drug delivery due to their size tunability and surface modifiability. Moreover, nano-drug delivery systems have demonstrated strong potential in terms of prolonging drug circulation time, improving bioavailability, increasing drug retention at the tumor site, decreasing drug resistance, as well as reducing the undesirable side effects of anticancer drugs. Numerous studies have focused on utilizing polysaccharides as nanodelivery carriers, developing delivery systems based on polysaccharides, or exploiting polysaccharides as tumor-targeting ligands to enhance the precision of nanoparticle delivery. These types of investigations have become commonplace in the academic literature. This review aims to elucidate the preparation methods and principles of polysaccharide gold nanocarriers. It also provides an overview of the factors that affect the loading of polysaccharide gold nanocarriers with different kinds of drugs. Additionally, it outlines the strategies employed by polysaccharide gold nanocarriers to improve the delivery efficiency of various drugs. The objective is to provide a reference for further development of research on polysaccharide gold nanodelivery systems.

show abstract

Section: Research On Polysaccharide-aunps As Drug Delivery Carriersmentioning

confidence: 99%

Research Progress of Polysaccharide-Gold Nanocomplexes in Drug Delivery

Song,

Aipire,

Dilxat

et al. 2024

Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…An effective solution to address this issue is using endogenous cell membranes as camouflage coatings to create a biomimetic nanoplatform [ 18 ]. Amongst various cell membranes, homologous tumour cell membranes offer a dual advantage by deceiving the MPS to evade clearance while concurrently improving the biodistribution of TSA and As through homologous targeting [ 27 , 29 , 30 ]. However, a notable challenge arises from the abundance of homologous tumour cells in ascites, a typical clinical feature of HCC, which substantially impedes the precise targeting capability of tumour cell membranes coating toward solid tumours.…”

Section: Introductionmentioning

confidence: 99%

Homologous-magnetic dual-targeted metal-organic framework to improve the Anti-hepatocellular carcinoma efficacy of PD-1 inhibitor

Guo,

Li,

Mao

et al. 2024

J Nanobiotechnol

View full text Add to dashboard Cite

The insufficient abundance and weak activity of tumour-infiltrating lymphocytes (TILs) are two important reasons for the poor efficacy of PD-1 inhibitors in hepatocellular carcinoma (HCC) treatment. The combined administration of tanshinone IIA (TSA) and astragaloside IV (As) can up-regulate the abundance and activity of TILs by normalising tumour blood vessels and reducing the levels of immunosuppressive factors respectively. For enhancing the efficacy of PD-1 antibody, a magnetic metal–organic framework (MOF) with a homologous tumour cell membrane (Hm) coating (Hm@TSA/As-MOF) is established to co-deliver TSA&As into the HCC microenvironment. Hm@TSA/As-MOF is a spherical nanoparticle and has a high total drug-loading capacity of 16.13 wt%. The Hm coating and magnetic responsiveness of Hm@TSA/As-MOF provide a homologous-magnetic dual-targeting, which enable Hm@TSA/As-MOF to counteract the interference posed by ascites tumour cells and enhance the precision of targeting solid tumours. Hm coating also enable Hm@TSA/As-MOF to evade immune clearance by macrophages. The release of TSA&As from Hm@TSA/As-MOF can be accelerated by HCC microenvironment, thereby up-regulating the abundance and activity of TILs to synergistic PD-1 antibody against HCC. This study presents a nanoplatform to improve the efficacy of PD-1 inhibitors in HCC, providing a novel approach for anti-tumour immunotherapy in clinical practice.

show abstract

Biomimetic Cell Membrane‐Coated Nanoparticles for Cancer Theranostics

Jiang,

Zhan,

Ding

et al. 2024

ChemMedChem

View full text Add to dashboard Cite

Nanoparticles can enhance drugs accumulating at the tumor site and hold tremendous promise for achieving effective tumor treatment. However, due to the complexity of cancer heterogeneity and suppressive tumor microenvironment, the delivery of traditional nanoparticles has poor infiltration and off‐target effects, making it difficult to control the drug release rate and causing off‐target toxicity. In recent years, cell membrane‐coated biomimetic nanoparticles have been developed, which have both the natural characteristics of biomembranes and the physical characteristics of traditional nanoparticles, thus improving the homologous targeting ability of nanoparticles to tumor cells and better biocompatibility. In this paper, we reviewed the application of single cell membrane and hybrid cell membrane‐coated biomimetic nanoparticles in the integration for tumor diagnosis and treatment. We talked about the preparation methods of cell membrane‐coated nanoparticles, the targeting mechanisms, and the effects of imaging and therapeutic outcomes of different cell membrane‐coated biomimetic nanoparticles in detail. Finally, we discussed the existing problems and prospects of cell membrane‐coated biomimetic nanomaterials.

show abstract

Biomimetic Gold Nanorods Modified with Erythrocyte Membranes for Imaging-Guided Photothermal/Gene Synergistic Therapy

Cited by 8 publications

References 61 publications

Research Progress of Polysaccharide-Gold Nanocomplexes in Drug Delivery

Research Progress of Polysaccharide-Gold Nanocomplexes in Drug Delivery

Homologous-magnetic dual-targeted metal-organic framework to improve the Anti-hepatocellular carcinoma efficacy of PD-1 inhibitor

Biomimetic Cell Membrane‐Coated Nanoparticles for Cancer Theranostics

Contact Info

Product

Resources

About