Biomimetic hydration lubrication with various polyelectrolyte layers on cross-linked polyethylene orthopedic bearing materials

Kyomoto, Masayuki; Moro, Toru; Saiga, Kenichi; Hashimoto, Masami; Ito, Hiromitsu; Kawaguchi, Hiroshi; Takatori, Yoshio; Ishihara, Kazuhíko

doi:10.1016/j.biomaterials.2012.03.028

Cited by 90 publications

(83 citation statements)

References 51 publications

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“…Articular cartilage consists of surface-active phospholipids, chondrocytes, and surrounding matrix macromolecules, such as proteoglycans, glycosaminoglycans, and collagens. Because of their charge, they can trap water to maintain the water-fluid and electrolyte balance, which provides hydrophilicity and affords effective boundary lubrication [32]. The thin-film fluid lubrication of the hydrated layer of articular cartilage is essential to the smooth movement of natural synovial joints.…”

Section: Discussionmentioning

confidence: 99%

“…The thin-film fluid lubrication of the hydrated layer of articular cartilage is essential to the smooth movement of natural synovial joints. Considering that the study and mimicking of nature has been widely successful in science and technology, an investigation of the bearing surfaces of artificial joints with the purpose of mimicking cartilage by surface modification appears promising [32].…”

Section: Discussionmentioning

confidence: 99%

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Smart PEEK Modified by Self-Initiated Surface Graft Polymerization for Orthopedic Bearings

Kyomoto¹,

Moro²,

Yamane³

et al. 2014

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Poly(ether-ether-ketone) (PEEK)s are a group of polymeric biomaterials with excellent mechanical properties, chemical stability, and nonmagnetism. In the present study, we propose a novel self-initiated surface graft polymerization technique, using which we demonstrate the fabrication of a highly hydrophilic and biocompatible nanometer-scale layer on the surfaces of PEEK and carbon fiber-reinforced PEEK (CFR-PEEK) by the photoinduced graft polymerization of 2-methacryloyloxyethyl phosphorylcholine (MPC) without using any photoinitiators. The thus formed hydrophilic and smooth 100-nm-thick PMPC-grafted layer caused a significant reduction in the sliding friction of the bearing interface because the thin water film and hydrated PMPC layer acted as extremely efficient lubricants (so-called fluid-film lubrication or hydration lubrication). Fluid-film lubrication suppressed the direct contact of the counterbearing surface with the PEEK substrate and thus reduced the frictional force. A PMPC-grafted layer is therefore expected to significantly increase bearing durability. Furthermore, the PMPC-grafted layer shows unique phenomena, e.g., it prevents damage of the metal counter surface regardless of the carbon fiber content of CFR-PEEK. Smart PEEK using the self-initiated surface graft polymerization of MPC should lead to development of novel orthopedic bearings.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Smart PEEK Modified by Self-Initiated Surface Graft Polymerization for Orthopedic Bearings

Kyomoto¹,

Moro²,

Yamane³

et al. 2014

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“…Current artificial joints with polyethylene (PE) surfaces have considerably less efficient lubrication and thus much greater wear, leading to osteolysis and aseptic loosening. Then, they reported the development of nanometer-scale hydrophilic layers with varying charge (nonionic, cationic, anionic, or zwitterionic) on cross-linked PE (CLPE) surfaces, which could fully mimic the hydrophilicity and lubricity of the natural joint surface [42]. The POEGMA-and PMPC-grafted CLPE cups exhibited high wear resistance in the hip simulator tests along with low coefficients of dynamic friction in the ball-on-plate friction tests.…”

Section: Improved Wear Resistant By Surface Grafted Polymer Brushesmentioning

confidence: 99%

Physicochemistry aspects on frictional interfaces

Zhou

Liu

2017

Friction

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Friction exists wherever relative motion occurs and is the main source of energy consumption. Lubrication plays a significant role in improving fuel efficiency, reducing emissions, and prolonging the service life of machines. Surface interactions between two moving solid surfaces or the flow of a fluid (and/or environment) on a solid surface are the primary causes of friction. Apart from the mechanical design of moving parts, surface physicochemistry is of crucial importance to lubrication. This review deals with the frontier research on controlling friction and lubrication, highlights the importance of physicochemistry aspects, and enumerates the state-of-the-art chemistry solutions to tribological issues. It aims at inspiring talented young scientists from different fields to make significant contributions to the area.

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“…Modification of the bearing surfaces of an artificial joint with a hydrophilic layer should increase lubrication to levels comparable to that provided by articular cartilage under physiological conditions [17,20,21,23]. 2-Methacryloyloxyethyl phosphorylcholine (MPC) polymers are one of the most common biocompatible and hydrophilic polymers that have been clinically applied [13,35,36].…”

Section: Introductionmentioning

confidence: 99%

“…2-Methacryloyloxyethyl phosphorylcholine (MPC) polymers are one of the most common biocompatible and hydrophilic polymers that have been clinically applied [13,35,36]. It has been demonstrated that a nanometer-scale layer of PMPC can be formed on a crosslinked PE (CLPE) surface to better reproduce the ideal hydrophilicity and lubricity of the physiological joint surface [18,[20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Multidirectional Wear and Impact-to-wear Tests of Phospholipid-polymer-grafted and Vitamin E-blended Crosslinked Polyethylene: A Pilot Study

Kyomoto

Moro

Takatori

et al. 2015

Clinical Orthopaedics &Amp; Related Research

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Background Modifying the surface and substrate of a crosslinked polyethylene (CLPE) liner may be beneficial for high wear resistance as well as high oxidative stability and excellent mechanical properties, which would be useful in contributing to the long-term performance of orthopaedic bearings. A grafted poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) layer on a vitamin E-blended crosslinked PE (HD-CLPE[VE]) surface may provide hydrophilicity and lubricity without compromising the oxidative stability or mechanical properties. Questions/purposes (1) Will the modifications (PMPC grafting and vitamin E blending) affect the lubrication characteristics of the CLPE surface? (2) Will the modifications affect wear resistance? (3) Will the modifications affect fatigue resistance? Methods We investigated the effects of surface and substrate modifications (PMPC grafting and vitamin E blending) on the wear and fatigue fracture of thin CLPE samples. For each of the untreated and PMPC-grafted CLPE surfaces with and without vitamin E blended (four groups), wettability and lubricity surface analyses were conducted as well as multidirectional wear and impact-towear tests using a pin-on-disk testing machine. Results The water wettability and lubricity (CLPE [mean ± 95% confidence interval]: 23.2°± 1.8°, 0.005 ± 0.001; HD-CLPE[VE]: 26.0°± 2.3°, 0.009 ± 0.003) of the PMPCgrafted surfaces were greater (p \ 0.001) than that (CLPE: 90.3°± 1.2°, 0.067 ± 0.015; HD-CLPE[VE]: 90.8°± 2.0°, 0.063 ± 0.008) of the untreated surface regardless of vitamin E additives. It was observed that the PMPC grafting (CLPE: 0.23 ± 0.06 mg; HD-CLPE[VE]: 0.05 ± 0.10 mg) was associated with reduced gravimetric wear (CLPE: 0.53 ± 0.08 mg, p = 0.004 HD-CLPE[VE]: 0.23 ± 0.07 mg, p = 0.038) in the multidirectional wear test. The PMPC-grafted surface characteristics did not appear to affect the impact fatigue resistance regardless of vitamin E blending. Conclusions PMPC grafting improved the surface hydrophilicity and lubricity, and it reduced the gravimetric wear in terms of multidirectional sliding. It did not result in differences in terms of the impact-to-unidirectional sliding regardless of vitamin E blending. Further research is needed to evaluate the wear resistance of PMPC-grafted HD-CLPE(VE) in long-term hip simulator tests under normal

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Biomimetic hydration lubrication with various polyelectrolyte layers on cross-linked polyethylene orthopedic bearing materials

Cited by 90 publications

References 51 publications

Smart PEEK Modified by Self-Initiated Surface Graft Polymerization for Orthopedic Bearings

Smart PEEK Modified by Self-Initiated Surface Graft Polymerization for Orthopedic Bearings

Physicochemistry aspects on frictional interfaces

Multidirectional Wear and Impact-to-wear Tests of Phospholipid-polymer-grafted and Vitamin E-blended Crosslinked Polyethylene: A Pilot Study

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