Biomimetic Implant Surfaces and Their Role in Biological Integration—A Concise Review

Cruz, Mariana; Silva, Neusa; Marques, Joana; Mata, António DSP da; Silva, Felipe Samuel; Caramês, João

doi:10.3390/biomimetics7020074

Cited by 23 publications

(21 citation statements)

References 123 publications

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“…The influential factors on CA apart from surface roughness may be originated from surface chemistry and texture form on the surface, as reported elsewhere. 1,11,39,45,48 Therefore, it is thought that the non-linear relation between CA and Sa values may be related to the surface chemistry and texture form of the surface. Figure 2(d)–(e) depict the images captured during the wettability test of specimens.…”

Section: Resultsmentioning

confidence: 99%

“…Some studies indicate that the surface roughness is in the microscale range, 1-10 mm, to promote contact and adhesion between the implant surface and the bone and speed osseointegration. 39,40 It has been emphasized in relevant studies that hydrophilic surfaces are more advantageous in providing osseointegration compared to hydrophobic surfaces. 24,[41][42][43] To verify hydrophilicity, statistical assessments of surface roughness and contact angle were performed.…”

Section: Discussionmentioning

confidence: 99%

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Laser textured Ti-6Al-7Nb alloy for biomedical applications: An investigation of texturing parameters on surface properties

Ozan,

Bilgin,

Kasman

2023

Proc Inst Mech Eng H

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Surface texturing with a laser beam is an effective method for engraving on the surface of biomaterials. The four laser texturing parameters (scan speed, frequency, fill spacing, and pulse width) having five different values were associated with five different scanning strategies (scan direction), and a total of 25 texturing conditions were tested on the Ti-6Al-7Nb alloy surface. The surface roughness and wettability of the textures created with a 20 W nanosecond fiber laser with a wavelength of 1064 nm on the surface of Ti-6Al-7Nb biocompatible alloy were investigated. Laser texturing parameters were analyzed according to the lowest surface roughness and a hydrophilic surface by creating L25 orthogonal arrays. The surface roughness values ranged between 2 and 26 µm. The lowest surface roughness with a value of 2.21 µm was achieved when the texture was processed with a frequency of 150 kHz, a fill spacing of 0.02 mm, a scan speed of 800 mm/s, a pulse width of 250 ns, and a cross-hatch strategy of 0°/90°. Considering the wettability test results, it was revealed that most of the textured surfaces have super hydrophilic and hydrophilic characteristics except the surface with a contact angle of 92.93°. The relevant surface was textured with 75 kHz frequency, 1000 mm/s scan speed, 0.05 mm fill spacing, 200 ns pulse width, and 45°/−45° cross-hatch strategy.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Laser textured Ti-6Al-7Nb alloy for biomedical applications: An investigation of texturing parameters on surface properties

Ozan,

Bilgin,

Kasman

2023

Proc Inst Mech Eng H

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“…CAP-treated surfaces and leukocyte response have been investigated before, albeit to a lesser extent with argon plasma. Oxygen but not nitrogen or air plasma led to a pro-inflammatory response (increased IL1β and TNFα release) [ 77 , 81 , 82 ]. Additionally, sample fixation did not affect leukocyte response, which is in line with previous findings [ 83 ].…”

Section: Discussionmentioning

confidence: 99%

In-Vitro Biofilm Removal Efficacy Using Water Jet in Combination with Cold Plasma Technology on Dental Titanium Implants

Matthes

Jablonowski

Miebach

et al. 2023

IJMS

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Peri-implantitis-associated inflammation can lead to bone loss and implant failure. Current decontamination measures are ineffective due to the implants’ complex geometry and rough surfaces providing niches for microbial biofilms. A modified water jet system (WaterJet) was combined with cold plasma technology (CAP) to achieve superior antimicrobial efficacy compared to cotton gauze treatment. Seven-day-old multi-species-contaminated titanium discs and implants were investigated as model systems. The efficacy of decontamination on implants was determined by rolling the implants over agar and determining colony-forming units supported by scanning electron microscopy image quantification of implant surface features. The inflammatory consequences of mono and combination treatments were investigated with peripheral blood mononuclear cell surface marker expression and chemokine and cytokine release profiles on titanium discs. In addition, titanium discs were assayed using fluorescence microscopy. Cotton gauze was inferior to WaterJet treatment according to all types of analysis. In combination with the antimicrobial effect of CAP, decontamination was improved accordingly. Mono and CAP-combined treatment on titanium surfaces alone did not unleash inflammation. Simultaneously, chemokine and cytokine release was dramatically reduced in samples that had benefited from additional antimicrobial effects through CAP. The combined treatment with WaterJet and CAP potently removed biofilm and disinfected rough titanium implant surfaces. At the same time, non-favorable rendering of the surface structure or its pro-inflammatory potential through CAP was not observed.

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“…In comparison to alternative implant designs, a surface topography with an appropriate porosity structure can offer various biomedical benefits for bone-implant integration. [9][10][11] In multiple preclinical studies, several researchers investigated the impact of porous-surface design on implant osseointegration. 12,13 This regeneration effect can be achieved by adding a pharmacological agent to the chemical composition of the material.…”

Section: Introductionmentioning

confidence: 99%

Method of computational design for additive manufacturing of hip endoprosthesis based on basic‐cell concept

Bolshakov,

Kuchumov,

Kharin

et al. 2024

Numer Methods Biomed Eng

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Endoprosthetic hip replacement is the conventional way to treat osteoarthritis or a fracture of a dysfunctional joint. Different manufacturing methods are employed to create reliable patient‐specific devices with long‐term performance and biocompatibility. Recently, additive manufacturing has become a promising technique for the fabrication of medical devices, because it allows to produce complex samples with various structures of pores. Moreover, the limitations of traditional fabrication methods can be avoided. It is known that a well‐designed porous structure provides a better proliferation of cells, leading to improved bone remodeling. Additionally, porosity can be used to adjust the mechanical properties of designed structures. This makes the design and choice of the structure's basic cell a crucial task. This study focuses on a novel computational method, based on the basic‐cell concept to design a hip endoprosthesis with an unregularly complex structure. A cube with spheroid pores was utilized as a basic cell, with each cell having its own porosity and mechanical properties. A novelty of the suggested method is in its combination of the topology optimization method and the structural design algorithm. Bending and compression cases were analyzed for a cylinder structure and two hip implants. The ability of basic‐cell geometry to influence the structure's stress–strain state was shown. The relative change in the volume of the original structure and the designed cylinder structure was 6.8%. Computational assessments of a stress–strain state using the proposed method and direct modeling were carried out. The volumes of the two types of implants decreased by 9% and 11%, respectively. The maximum von Mises stress was 600 MPa in the initial design. After the algorithm application, it increased to 630 MPa for the first type of implant, while it is not changing in the second type of implant. At the same time, the load‐bearing capacity of the hip endoprostheses was retained. The internal structure of the optimized implants was significantly different from the traditional designs, but better structural integrity is likely to be achieved with less material. Additionally, this method leads to time reduction both for the initial design and its variations. Moreover, it enables to produce medical implants with specific functional structures with an additive manufacturing method avoiding the constraints of traditional technologies.

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Biomimetic Implant Surfaces and Their Role in Biological Integration—A Concise Review

Cited by 23 publications

References 123 publications

Laser textured Ti-6Al-7Nb alloy for biomedical applications: An investigation of texturing parameters on surface properties

Laser textured Ti-6Al-7Nb alloy for biomedical applications: An investigation of texturing parameters on surface properties

In-Vitro Biofilm Removal Efficacy Using Water Jet in Combination with Cold Plasma Technology on Dental Titanium Implants

Method of computational design for additive manufacturing of hip endoprosthesis based on basic‐cell concept

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