Biomimetic Matrices for Integrin-Mediated Cell Adhesion

Ashe, Keshia M.; Lee, Duron A.; Lo, Kevin W.‐H.; Nair, Lakshmi S.; Laurencin, Cato T.

doi:10.1142/9789814295680_0011

Cited by 4 publications

(2 citation statements)

References 188 publications

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“…98 Physical properties of ceramics, such as porosity (i.e., pore shape, pore size, and interconnectivity), can influence cell behavior during osteogenesis, as the material can resemble the structure of cancellous bone and promote neovascularization. [99][100][101] Taqvi and Roy have demonstrated that the optimal osseous cell-stimulating interconnected pore size should be in the range of 100-200 μm, while the cell-desired diameter of pores varies between 200 and 600 μm, leading to the ideal pore volume ranges from 40% to 80%. Matrix pore size less than 150 μm inversely relates to stem cell hematopoiesis.…”

Section: Physiochemical Propertiesmentioning

confidence: 99%

Advanced graphene ceramics and their future in bone regenerative engineering

Hosseini

Laurencin

2022

Int J Applied Ceramic Tech

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The outstanding properties of graphene materials rely on an exceptional two‐dimensional honeycombed lattice. The lattice allows for electrical, thermal, and mechanical reinforcement effects when applied to the ceramic matrix. The biocompatibility of the material allows for providing multifunctional bioceramics applications. However, the potential of graphene lies in its ability to be homogenously distributed as part of a ceramic matrix. Therefore, appropriate processing techniques are important for attaining desired graphene ceramic properties applicable for regenerative biomedical purposes. This article provides an inclusive review of the current knowledge of advanced graphene‐based ceramics for bone regenerative engineering. In this review, the opportunities and challenges in utilizing graphene materials in combination with ceramics suitable for applications in load‐bearing bone defects are discussed.

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Section: Physiochemical Propertiesmentioning

confidence: 99%

Advanced graphene ceramics and their future in bone regenerative engineering

Hosseini

Laurencin

2022

Int J Applied Ceramic Tech

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“…The cell–matrix interactions of the scaffolds can also be improved by coating or grafting or co-electrospinning cell-adhesive peptides containing proteins such as collagen, gelatin, and FN. − A rat in vivo (rotator cuff model) study demonstrated not only improved cellular proliferation, but also cartilage regeneration at the insertion site in gelatin-grafted PLA nanofibers, compared to neat PLA nanofibers . In addition, picrosirius red staining and birefringence analyses showed total areas of metachromasia and collagen orientation, respectively, to be higher in gelatin-grafted PLA, indicating the potential of gelatin grafted nanofibers for regenerating the tendon–bone insertion site .…”

Section: Scaffolds For Regenerating Rotator Cuff Tendonsmentioning

confidence: 99%

Regenerative Engineering of the Rotator Cuff of the Shoulder

Narayanan

Nair

Laurencin

2018

ACS Biomater. Sci. Eng.

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Rotator cuff tears often heal poorly, leading to re-tears after repair. This is in part attributed to the low proliferative ability of the resident cells (tendon fibroblasts and tendon-stem cells) upon injury to the rotator cuff tissue and the low vascularity of the tendon insertion. In addition, surgical outcomes of current techniques used in clinical settings are often suboptimal, leading to the formation of neo-tissue with poor biomechanics and structural characteristics, which results in re-tears. This has prompted interest in a new approach, which we term as "Regenerative Engineering", for regenerating rotator cuff tendons. In the Regenerative Engineering paradigm, roles played by stem cells, scaffolds, growth factors/small molecules, the use of local physical forces, and morphogenesis interplayed with clinical surgery techniques may synchronously act, leading to synergistic effects and resulting in successful tissue regeneration. In this regard, various cell sources such as tendon fibroblasts and adult tissue-derived stem cells have been isolated, characterized, and investigated for regenerating rotator cuff tendons. Likewise, numerous scaffolds with varying architecture, geometry, and mechanical characteristics of biologic and synthetic origin have been developed. Furthermore, these scaffolds have been also fabricated with *

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