Biomimetic membranes made of conducting polymers doped with adenosine diphosphate (ADP)

Electrochemical Properties of the Poly(3,4‐ethylenedioxythiophene) Doped with Taurine Ligands

“…Biological molecules (biologically active ligands (BLs)) are compatible with CPs and can be dispersed in CPs as the active sites (CP-BL). This approach may be used in modeling iontransport and ion-exchange processes as well as for controlled release of charged biomolecules [6,[20][21][22][23][24][25][26][27][28].…”

“…Lewenstam et al [20][21][22][23][24][25][26] have developed a model membrane concept where conducting polymers are doped during electrochemical polymerization with different BLs. Model membranes of this type enabled studying membrane potential formation mechanisms as well as the relationship between potential and ion-fluxes in biologically active sites with respect to the major physiologically relevant cations [32,33], to which the film is made sensitive.…”

“…Firstly, the film is electropolymerized and biological ligands are dispersed in the CP structure as doping ions. Secondly, cationic sensitivity based on the complexation of BL and metal cation [23][24][25][26] is induced by a conditioning procedure with carefully chosen parameters, and the sensitized film can be described as CP-BL-Me. It has been found that the complexing properties of many ligands observed in aqueous solutions are preserved when the ligand is inserted in the CP phase [8-9, 16-19, 20-23].…”

“…Further, it has been shown that the sensitivity of a conducting polymer film to a particular ion is always associated with the presence of this ion in the membrane [6,17]. Optimization of these two processes, conditioning and electropolymerization, taking into account their effect on the polymer film surface morphology and topography is necessary for obtaining good sensitivity [22,25,26].…”

“…Earlier works have treated model membranes consisting of BLs such as adenosine triphosphate (ATP) [22,24,25], adenosine diphosphate (ADP) [26], heparin (Hep) [23], asparagine (Asp), and glutamine (Glu) [21,25] dispersed into conducting polymer matrix.…”