2021
DOI: 10.1016/j.micromeso.2021.111320
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Biomimetic mesoporous vectors enabling the efficient inhibition of wild-type isocitrate dehydrogenase in multiple myeloma cells

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Cited by 9 publications
(9 citation statements)
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“…Data are in agreement with previously published works, demonstrating that the lipidic bilayer offers a valid shell to (1) retain the encapsulated molecule and (2) prevent the rapid drug leakage and release from the NP pores, maximizing the drug accumulation in the intracellular compartments. 20,24,26…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Data are in agreement with previously published works, demonstrating that the lipidic bilayer offers a valid shell to (1) retain the encapsulated molecule and (2) prevent the rapid drug leakage and release from the NP pores, maximizing the drug accumulation in the intracellular compartments. 20,24,26…”
Section: Resultsmentioning
confidence: 99%
“…22 This approach offers several advantages: besides guaranteeing the colloidal stability of nanoparticles in biological media, it increases their biocompatibility and biomimicking features and improves the interaction with the cell membrane, facilitating the endocytosis process. 23 The lipidic bilayer also offers a valid barrier to the rapid drug leakage out of the nanoparticle pores, 20,24 avoiding off-target release, while assuring the drug delivery only intracellularly. Indeed, literature reports have shown the proficient use of lipid bilayer-coated nanoparticles for effective biostabilization in biological media 25 and for efficient cell internalization.…”
Section: Introductionmentioning
confidence: 99%
“…It is then foreseen to load the artificial EVs with active compounds, enabling an advanced function in terms of imaging reporter, diagnostic, or therapeutic activities. Examples of these various functions can derive from the already-reported literature concerning both natural EVs or liposomes, proposing the incorporation of drugs, , genetic materials, organic dyes, aptamers, peptides, and more in general proteins ranging from enzyme to antibodies, and even solid-state nanoparticles of various nature, size, porosities, properties, and functions. …”
Section: A Novel Practical Strategymentioning
confidence: 99%
“…4−6 One of the major trends includes the use of nanosystems incorporating imaging moieties and carrying antitumoral drugs, 7 such as polymeric nanoparticles (NPs), 8−11 liposomes, 12−14 or mesoporous silica NPs. 15,16 However, a main drawback of these devices is the inability to precisely control their release location, leading to an unwanted leakage of their cargo before correctly reaching the tumor environment.…”
Section: Introductionmentioning
confidence: 99%
“…Theranostic nanosystems are acquiring more and more relevance in nanomedicine . The potential advantages offered by the administration of a site-specific therapy while constantly monitoring the patient conditions are actually enormous in the context of cancer, as for all other diseases which are very difficult to treat. , Several prototypes of smart nanosized particles able to perform both these tasks can be found in the literature. One of the major trends includes the use of nanosystems incorporating imaging moieties and carrying anti-tumoral drugs, such as polymeric nanoparticles (NPs), liposomes, or mesoporous silica NPs. , However, a main drawback of these devices is the inability to precisely control their release location, leading to an unwanted leakage of their cargo before correctly reaching the tumor environment.…”
Section: Introductionmentioning
confidence: 99%