Biomimetic Metal Phenolates

Abstract

The chapter reports on recent studies of metal complexes that have the phenolate group as a ligand. The synthesis and characterization of many low molecular weight complexes is reviewed and commented on. Special attention is devoted to biomimetic models, for a deeper understanding of metalloprotein structures and functions. The chapter is divided into two parts, related to oxidant and antioxidant activities and to the hydrolysis of phospatediesters, respectively. Activity of phenols as antioxidants and V IV O 2+ , Mn II , Mn III , Mn IV ,Co II , Co III , Ni II , Cu I , Cu II and Zn II complexes with phenolato‐containing Schiff bases as biomimetic for biological systems, is the focus of the first part. A section is dedicated to selected Cu II and Pt II complexes having pharmaceutical active molecules as ligands, from the OXICAM family of non‐steroidal anti‐inflammatory drugs. The second part reports on metal–phenolato complexes as models for phosphodiesterase enzymes. Dinuclear complexes based on Zn II , Fe III /Zn II , Zn II /Mg II metal centers are reviewed and commented on

Cytotoxicity and Crystal Structures of Nitrosoruthenium Complexes mer‐[Ru(NO)Py2Cl3] and mer‐[Ru(NO)(γ‐Pic)2Cl3]

“…Bond angles at ruthenium are very close to 90°, while Ru‐N−O angle is nearly linear in both structures I and II , that is commonly for nitrosyl‐group with formula {RuNO} 3+ . The general distances and angles in the both structures (Table ) are also close to characteristic values for these type of compounds ,. Some differences in Ru−Cl, Ru‐N NO and N−O bonds are likely due to the above mentioned disorder of chloride and nitrosyl ligands.…”

“…The structure of II contains two independent molecules mer ‐[Ru(NO)(γ‐Pic) 2 Cl 3 ]; the first one shows the same disordering, while the second one reveals two positions with fully occupied Cl – and with Cl – /NO ligands of 0.5/0.5 occupancies. This type of disorder is well‐known for the compounds with Ru(NO)Cl 3 plane ,…”

“…The water insoluble complex mer‐[Ru(NO)Py 2 Cl 3 ] have been obtained a few times through the different synthetic procedures as admixture,, but the crystal structure of this complex hasn't been studied until now. There are complexes with other amine ligands known mer‐[Ru(NO)(L) 2 Cl 3 ], (where L – ethylisonicotinate or 4‐methylpyrimidine,, and 4‐cyanopyridine or 4‐aminopyridine) have been synthesized with yields 60–70% and structurally characterized by single‐crystal XRD, where Ru(NO)Cl 3 ⋅ n H 2 O was used as a precursor. The related picoline complexes were not presented in the literature until today.…”

Evaluation of Heavy Metals Toxicity in the Groundwater of Some Villages of Sirsa District of Haryana, India

“…8 Several studies proposed the occurrence of heavy metals in groundwater by the excessive use of fertilizers and pesticides, solid waste dumping, untreated and pesticides, solid waste dumping, untreated industrial wastes, mine drainage etc. [9][10][11] The heavy metal pollution of groundwater is a serious health problem all over the world due to its accumulation 11 . To avoid health problems, regular monitoring of heavy metals concentration is necessary.…”