Biomimetic mineralization of hydrogels

Douglas, Timothy

doi:10.1016/b978-1-78242-338-6.00010-7

Cited by 2 publications

(2 citation statements)

References 130 publications

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“…33 The mineral induction step, consisting of alternate exposure to high concentrations of Ca 2+ and PO 4 3− ions, is intended for increasing the local saturation within the porous matrix to induce a rapid emergence of reactive sites. 39 On the fibrils' surface, it is possible to observe spherical aggregates (see arrows in Figure 2B), probably representing ACP nuclei that facilitated a subsequent surface-directed mineralization process. 6 To induce crystal growth and crystallization, these nuclei were further exposed to 1× SBF, a medium with an ionic composition and pH similar to blood plasma.…”

Section: Resultsmentioning

confidence: 98%

“…A similar multistep approach has been adopted before in the mineralization of synthetic nanofibers relying on the SBF’s potential to generate apatite . The mineral induction step, consisting of alternate exposure to high concentrations of Ca 2+ and PO 4 3– ions, is intended for increasing the local saturation within the porous matrix to induce a rapid emergence of reactive sites . On the fibrils’ surface, it is possible to observe spherical aggregates (see arrows in Figure B), probably representing ACP nuclei that facilitated a subsequent surface-directed mineralization process .…”

Section: Resultsmentioning

confidence: 99%

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Surface-Directed Mineralization of Fibrous Collagen Scaffolds in Simulated Body Fluid for Tissue Engineering Applications

Júnior

Curylofo-Zotti

Reis

et al. 2021

ACS Appl. Bio Mater.

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The use of polymer additives that stabilize fluidic amorphous calcium phosphate is key to obtaining intrafibrillar mineralization of collagen in vitro. On the other hand, this biomimetic approach inhibits the nucleation of mineral crystals in unconfined extrafibrillar spaces, that is, extrafibrillar mineralization. The extrafibrillar mineral content is a significant feature to replicate from hard connective tissues such as bone and dentin as it contributes to the final microarchitecture and mechanical stiffness of the biomineral composite. Herein, we report a straightforward route to produce densely mineralized collagenous composites via a surface-directed process devoid of the aid of polymer additives. Simulated body fluid (1×) is employed as a biomimetic crystallizing medium, following a preloading procedure on the collagen surface to quickly generate the amorphous precursor species required to initiate matrix mineralization. This approach consistently leads to the formation of extrafibrillar bioactive minerals in bulk collagen scaffolds, which may offer an advantage in the production of osteoconductive collagen−apatite materials for tissue engineering and repair purposes.

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Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Surface-Directed Mineralization of Fibrous Collagen Scaffolds in Simulated Body Fluid for Tissue Engineering Applications

Júnior

Curylofo-Zotti

Reis

et al. 2021

ACS Appl. Bio Mater.

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The mineralization effect on chitosan hydrogel structure containing collagen and alkaline phosphatase

Skwarczyńska

Biniaś

Maniukiewicz

et al. 2019

Journal of Molecular Structure

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Introducing collagen the basic ingredient of bone tissue into the structure of chitosan gels that are formed at physiological body temperature, aims to create so-called biomimetic structures, which are close in composition to the natural composition of bone tissue. The aim of this study was to determine the influence of mineralization on the structural properties of thermosensitive chitosan-collagen gels containing alkaline phosphatase (ALP) by SEM, XRD FTIR and XPS analyses, compared to the previously presented structure of chitosan-collagen gels before mineralization.

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Biomimetic mineralization of hydrogels

Cited by 2 publications

References 130 publications

Surface-Directed Mineralization of Fibrous Collagen Scaffolds in Simulated Body Fluid for Tissue Engineering Applications

Surface-Directed Mineralization of Fibrous Collagen Scaffolds in Simulated Body Fluid for Tissue Engineering Applications

The mineralization effect on chitosan hydrogel structure containing collagen and alkaline phosphatase

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