Biomimetic mineralization on natural and synthetic polymers to prepare hybrid scaffolds for bone tissue engineering

Zou, Lin; Zhang, Yujue; Liu, Xiaocui; Chen, Jingdi; Zhang, Qiqing

doi:10.1016/j.colsurfb.2019.03.004

Cited by 83 publications

(51 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is generally accepted that in vitro biomineralization of a porous scaffold through a layer of an apatite formation over the scaffold surface could provide direct integration between host bone and the bioactive mineral layers, thereby accelerating bone healing [27]. The SBF solution is often used to imitate a physiological environment, which can nucleate bone-like HA on bone repair materials [50].…”

Section: Discussionmentioning

confidence: 99%

“…In vitro mineralization was performed by immersing the SF/SPI-based composite scaffolds into simulated body fluid (SBF). The SBF solution was prepared as reported in a previous work [27]. All the prepared samples (1 × 1 × 1 cm 3 ) were immersed in the 5 mL SBF solution and incubated at 37 • C for 1, 3, 7, and 14 days.…”

Section: Water Adsorption Of the Sf/spi-based Composite Scaffoldsmentioning

confidence: 99%

See 1 more Smart Citation

Synergistic Effects on Incorporation of β-Tricalcium Phosphate and Graphene Oxide Nanoparticles to Silk Fibroin/Soy Protein Isolate Scaffolds for Bone Tissue Engineering

Liu

Zheng

et al. 2020

Polymers

View full text Add to dashboard Cite

In bone tissue engineering, an ideal scaffold is required to have favorable physical, chemical (or physicochemical), and biological (or biochemical) properties to promote osteogenesis. Although silk fibroin (SF) and/or soy protein isolate (SPI) scaffolds have been widely used as an alternative to autologous and heterologous bone grafts, the poor mechanical property and insufficient osteoinductive capability has become an obstacle for their in vivo applications. Herein, β-tricalcium phosphate (β-TCP) and graphene oxide (GO) nanoparticles are incorporated into SF/SPI scaffolds simultaneously or individually. Physical and chemical properties of these composite scaffolds are evaluated using field emission scanning electron microscope (FESEM), X-ray diffraction (XRD) and attenuated total reflectance Fourier transformed infrared spectroscopy (ATR-FTIR). Biocompatibility and osteogenesis of the composite scaffolds are evaluated using bone marrow mesenchymal stem cells (BMSCs). All the composite scaffolds have a complex porous structure with proper pore sizes and porosities. Physicochemical properties of the scaffolds can be significantly increased through the incorporation of β-TCP and GO nanoparticles. Alkaline phosphatase activity (ALP) and osteogenesis-related gene expression of the BMSCs are significantly enhanced in the presence of β-TCP and GO nanoparticles. Especially, β-TCP and GO nanoparticles have a synergistic effect on promoting osteogenesis. These results suggest that the β-TCP and GO enhanced SF/SPI scaffolds are promising candidates for bone tissue regeneration.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Water Adsorption Of the Sf/spi-based Composite Scaffoldsmentioning

confidence: 99%

Synergistic Effects on Incorporation of β-Tricalcium Phosphate and Graphene Oxide Nanoparticles to Silk Fibroin/Soy Protein Isolate Scaffolds for Bone Tissue Engineering

Liu

Zheng

et al. 2020

Polymers

View full text Add to dashboard Cite

show abstract

“…Chemical crosslinking is often used for the fabrication of chitosan hydrogels with a good mechanical strength and uniform properties, while its preparation process is more complicated, and some crosslinkers have a high toxicity [ 67 ]. Poly(lactic acid) (PLA) [ 72 ] and poly(ethylene glycol) (PEG) [ 73 ] are two biocompatible synthetic polymers that have been used as chemical crosslinking agents to prepare chitosan-based hydrogels. Chitosan hydrogels formed by gelation can provide homogenous 3D scaffolds with good biocompatibility for cell growth and is promising for bone tissue engineering applications [ 72 ].…”

Section: Chitosan-based Biomimetically Mineralized Composite Matermentioning

confidence: 99%

“…Poly(lactic acid) (PLA) [ 72 ] and poly(ethylene glycol) (PEG) [ 73 ] are two biocompatible synthetic polymers that have been used as chemical crosslinking agents to prepare chitosan-based hydrogels. Chitosan hydrogels formed by gelation can provide homogenous 3D scaffolds with good biocompatibility for cell growth and is promising for bone tissue engineering applications [ 72 ]. Besides, hydrogel is also a common application form of chitosan used to repair dental hard tissues [ 74 , 75 ].…”

Section: Chitosan-based Biomimetically Mineralized Composite Matermentioning

confidence: 99%

“…A calcium solution and phosphorus solution of a certain concentration are slowly added to the pre-dissolved chitosan solution simultaneously and incubated for a period of time. In some cases, stirring or pH adjustment is also used in this process [ 44 , 72 , 90 ]. Another is the alternate soaking process.…”

Section: Chitosan-based Biomimetically Mineralized Composite Matermentioning

confidence: 99%

See 1 more Smart Citation

Chitosan-Based Biomimetically Mineralized Composite Materials in Human Hard Tissue Repair

Ren

et al. 2020

Molecules

View full text Add to dashboard Cite

Chitosan is a natural, biodegradable cationic polysaccharide, which has a similar chemical structure and similar biological behaviors to the components of the extracellular matrix in the biomineralization process of teeth or bone. Its excellent biocompatibility, biodegradability, and polyelectrolyte action make it a suitable organic template, which, combined with biomimetic mineralization technology, can be used to develop organic-inorganic composite materials for hard tissue repair. In recent years, various chitosan-based biomimetic organic-inorganic composite materials have been applied in the field of bone tissue engineering and enamel or dentin biomimetic repair in different forms (hydrogels, fibers, porous scaffolds, microspheres, etc.), and the inorganic components of the composites are usually biogenic minerals, such as hydroxyapatite, other calcium phosphate phases, or silica. These composites have good mechanical properties, biocompatibility, bioactivity, osteogenic potential, and other biological properties and are thus considered as promising novel materials for repairing the defects of hard tissue. This review is mainly focused on the properties and preparations of biomimetically mineralized composite materials using chitosan as an organic template, and the current application of various chitosan-based biomimetically mineralized composite materials in bone tissue engineering and dental hard tissue repair is summarized.

show abstract

Mechanistically Scoping Cell‐Free and Cell‐Dependent Artificial Scaffolds in Rebuilding Skeletal and Dental Hard Tissues

Xiang

et al. 2022

Advanced Materials

View full text Add to dashboard Cite

Rebuilding mineralized tissues in skeletal and dental systems remains costly and challenging. Despite numerous demands and heavy clinical burden over the world, sources of autografts, allografts, and xenografts are far limited, along with massive risks including viral infections, ethic crisis, and so on. Per such dilemma, artificial scaffolds have emerged to provide efficient alternatives. To date, cell‐free biomimetic mineralization (BM) and cell‐dependent scaffolds have both demonstrated promising capabilities of regenerating mineralized tissues. However, BM and cell‐dependent scaffolds have distinctive mechanisms for mineral genesis, which makes them methodically, synthetically, and functionally disparate. Herein, these two strategies in regenerative dentistry and orthopedics are systematically summarized at the level of mechanisms. For BM, methodological and theoretical advances are focused upon; and meanwhile, for cell‐dependent scaffolds, it is demonstrated how scaffolds orchestrate osteogenic cell fate. The summary of the experimental advances and clinical progress will endow researchers with mechanistic understandings of artificial scaffolds in rebuilding hard tissues, by which better clinical choices and research directions may be approached.

show abstract

Biomimetic mineralization on natural and synthetic polymers to prepare hybrid scaffolds for bone tissue engineering

Cited by 83 publications

References 26 publications

Synergistic Effects on Incorporation of β-Tricalcium Phosphate and Graphene Oxide Nanoparticles to Silk Fibroin/Soy Protein Isolate Scaffolds for Bone Tissue Engineering

Synergistic Effects on Incorporation of β-Tricalcium Phosphate and Graphene Oxide Nanoparticles to Silk Fibroin/Soy Protein Isolate Scaffolds for Bone Tissue Engineering

Chitosan-Based Biomimetically Mineralized Composite Materials in Human Hard Tissue Repair

Mechanistically Scoping Cell‐Free and Cell‐Dependent Artificial Scaffolds in Rebuilding Skeletal and Dental Hard Tissues

Contact Info

Product

Resources

About