Biomimetic Morphology-Controlled Anhydrous Guanine via an Amorphous Intermediate

Kimura, Tsubasa; Takasaki, Mihiro; Oaki, Yuya; Imai, Hiroaki

doi:10.1021/acs.cgd.0c00140

Cited by 14 publications

(20 citation statements)

References 38 publications

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“…A number of previous studies aimed to achieve similar control of the polymorph and morphology of guanine crystals synthetically in the last years [34–38] . Utilizing chitosan substrates in the presence of poly( l ‐glutamic acid), Oaki et al.…”

Section: Methodsmentioning

confidence: 99%

“…Kimura et al. controlled the morphology of β‐AG through the transformation of an amorphous intermediate consisting of guanine sodium salt [38] . Recently, we developed a facile route that produces nanoplatelets exposing (100) plane with almost pure β phase [36] .…”

Section: Methodsmentioning

confidence: 99%

“…An umber of previouss tudies aimed to achieve similarc ontrol of the polymorph and morphology of guanine crystalssyntheticallyi nt he last years. [34][35][36][37][38] Utilizing chitosans ubstrates in the presence of poly(l-glutamic acid), Oaki et al synthesized a thin layer of aggregates of platy AG crystals,w hile it is unclear whether the synthesized AG is a or b phased ue to the low quality of X-ray diffraction patterns. [35] Gur et al demonstrated the polymorph controlb etween GM and AG by controlling the pH in the aqueous environment.…”

mentioning

confidence: 99%

“…[34] Kimura et al controlled the morphology of b-AG through the transformation of an amorphous intermediate consisting of guanine sodium salt. [38] Recently,w ed evelopedafacile route that produces nanoplatelets exposing (100) plane with almost pure b phase. [36] This is achievedt hrough ap hase transformation of ah ydrated amorphous guaninep hase in an organic solvent, such as dimethyl sulfoxide, with the presence of polyvinylpyrrolidone( PVP).…”

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confidence: 99%

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Synthesis of Bio‐Inspired Guanine Microplatelets: Morphological and Crystallographic Control

Chen

Liu

et al. 2020

Chemistry A European J

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b-Phase anhydrous guanine (b-AG) crystalsa re one of the most widespreado rganic crystals to construct optical structures in organisms. Currently,n os ynthetic method is available that allows for producing guanine crystals with similarc ontrol in size, morphology,a nd crystallographya si nb iological ones. Herein, af acile one-step synthesis route to fabricateb io-inspired guaninem icroplatelets with (100) exposing planesi na lmost pure b-phase is reported. Thes ynthesis is based on ap recipitation process of ag uanine sodium hydroxide solution in formamide with poly(1-vinylpyrrolidone-co-vinyl acetate) as a morphologicala dditive. Due to their uniform size (ca. 20 mm) and thickness (ca. 110nm), the crystals represent the first synthetic guanine microplatelets that exhibit strong structuralc olorationa nd pearlescent lusters. Moreover,t his synthesis route was utilized as am odel system to investigate the effects of guanine analogues, including uric acid, hypoxanthine, xanthine,a denine,a nd guanosine, during the crystallization process. Our results indicate that the introduction of guanine analogues not only can reduce the required synthesis temperature but also provide av ersatile control in crystal morphologya nd polymorph selection between the a-phase AG (a-AG)a nd bAG. Turbiditye xperiments showt hat the bAG microplatelets are formed with af ast precipitation rate in comparison to a-AG, suggesting that the formation of bAG crystals follows ak inetically driven process.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Synthesis of Bio‐Inspired Guanine Microplatelets: Morphological and Crystallographic Control

Chen

Liu

et al. 2020

Chemistry A European J

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“…PVP could tune the crystallization process of guanine and induce the formation of β-AG nanoplatelets exposing the (100) plane (Figure g,h). Moreover, Imai and co-workers synthesized flaky and columnar β-AG microcrystals through the transformation of an amorphous intermediate of guanine sodium salt under aqueous conditions …”

Section: Controlled Synthesis Of Single-crystalline β-Ag Micro- and N...mentioning

confidence: 99%

Bioinspired Crystallization of Guanine

Chen

Guo

Gao

et al. 2021

J. Phys. Chem. Lett.

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The Non‐Classical Crystallization Mechanism of a Composite Biogenic Guanine Crystal

et al. 2022

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Spectacular colors and visual phenomena in animals are produced by light interference from highly reflective guanine crystals. Little is known about how organisms regulate crystal morphology to tune the optics of these systems. By following guanine crystal formation in developing spiders, a crystallization mechanism is elucidated. Guanine crystallization is a “non‐classical,” multistep process involving a progressive ordering of states. Crystallization begins with nucleation of partially ordered nanogranules from a disordered precursor phase. Growth proceeds by orientated attachment of the nanogranules into platelets which coalesce into single crystals, via progressive relaxation of structural defects. Despite their prismatic morphology, the platelet texture is retained in the final crystals, which are composites of crystal lamellae and interlamellar sheets. Interactions between the macromolecular sheets and the planar face of guanine appear to direct nucleation, favoring platelet formation. These findings provide insights on how organisms control the morphology and optical properties of molecular crystals.

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Biomimetic Morphology-Controlled Anhydrous Guanine via an Amorphous Intermediate

Cited by 14 publications

References 38 publications

Synthesis of Bio‐Inspired Guanine Microplatelets: Morphological and Crystallographic Control

Synthesis of Bio‐Inspired Guanine Microplatelets: Morphological and Crystallographic Control

Bioinspired Crystallization of Guanine

The Non‐Classical Crystallization Mechanism of a Composite Biogenic Guanine Crystal

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