Biomimetic multifunctional nanozymes enhanced radiosensitization for breast cancer <i>via</i> an X-ray triggered cascade reaction

Yang, Lin; Du, Xiao; Qin, Yanru; Wang, Xueyuan; Zhang, Liefeng; Chen, Zhimeng; Wang, Zhongjie; Xu, Yu; Lei, Meng; Zhu, Yongqiang

doi:10.1039/d2tb00184e

Cited by 14 publications

(10 citation statements)

References 30 publications

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“…Preparation of BSA-Incubated Cerium Oxide Nanoparticles (CeO2@BSA Nanoparticles): According to previous literature reports, [24,54] 0.25 mL of Ce(NO 3 ) 3 •6H 2 O (0.1 m, Aladdin) aqueous solution was first mixed with 4.5 mL BSA solution (25 mg mL −1 , Aladdin), and then stirred vigorously at 80 °C for 15 min. Subsequently, the above mixed solution was rapidly added to 0.3 mL of KOH solution (1 m, Aladdin) and the reaction was stirred for 2 h. The obtained product was then dialyzed in ultrapure water for 24 h using dialysis bags (Thermo Scientific, 10 kD).…”

Section: Methodsmentioning

confidence: 99%

“…The average particle size of CeNPs measured by dynamic light scattering (DLS) was about 4.97 ± 1.39 nm (Figure 2b). In order to assess the stability of CeNPs, the diameter of nanoparticles after storage at 4 °C for different times (12,24,48,72, and 96 h) was detected and no significant change was found (Figure S1a, Supporting Information). According to the result of Fourier transform infrared (FT-IR) spectroscopy, CeNPs and BSA had common characteristic peaks (1650 and 3300 cm −1 ), confirming the existence of BSA in CeNPs (Figure 2c).…”

Section: Fabrication and Characterization Of Cenpsmentioning

confidence: 99%

“…In our previous research, CeO 2 nanoparticles were synthesized using a convenient and efficient bovine serum albumin (BSA) incubation strategy, in which BSA, due to its unique spatial structure, offered a space confinement for the growth and prevention of aggregation of nanoparticles. [24] Moreover, CeO 2 nanoparticles-loaded hydrogels were further applied to treat atopic dermatitis, [25] ocular surface diseases, [26] and chronic wounds [27] via removing toxic ROS. However, it has not been proved that the antioxidant CeO 2 -embedded hydrogel, especially in combination with NSCs transplantation, is effective in the treatment of SCI.…”

Section: Introductionmentioning

confidence: 99%

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ROS‐Scavenging Hydrogels Synergize with Neural Stem Cells to Enhance Spinal Cord Injury Repair via Regulating Microenvironment and Facilitating Nerve Regeneration

Liu

Shi

et al. 2023

Adv Healthcare Materials

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Although stem cell‐based therapy is recognized as a promising therapeutic strategy for spinal cord injury (SCI), its efficacy is greatly limited by local reactive oxygen species (ROS)‐abundant and hyper‐inflammatory microenvironments. It is still a challenge to develop bioactive scaffolds with outstanding antioxidant capacity for neural stem cells (NSCs) transplantation. In this study, albumin biomimetic cerium oxide nanoparticles (CeO2@BSA nanoparticles, CeNPs) are prepared in a simple and efficient manner and dispersed in gelatin methacryloyl to obtain the ROS‐scavenging hydrogel (CeNP‐Gel). CeNP‐Gel synergistically promotes neurogenesis via alleviating oxidative stress microenvironments and improving the viability of encapsulated NSCs. More interestingly, in the presence of CeNP‐Gel, microglial polarization to anti‐inflammatory M2 subtype are obviously facilitated, which is further verified to be associated with phosphoinositide 3‐kinase/protein kinase B pathway activation. Additionally, the injectable ROS‐scavenging hydrogel is confirmed to induce the integration and neural differentiation of transplanted NSCs. Compared with the blank‐gel group, the survival rate of NSCs in CeNP‐Gel group is about 3.5 times higher, and the neural differentiation efficiency is about 2.1 times higher. Therefore, the NSCs‐laden ROS‐scavenging hydrogel represents a comprehensive strategy with great application prospect for the treatment of SCI through comprehensively modulating the adverse microenvironment.

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Section: Methodsmentioning

confidence: 99%

Section: Fabrication and Characterization Of Cenpsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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ROS‐Scavenging Hydrogels Synergize with Neural Stem Cells to Enhance Spinal Cord Injury Repair via Regulating Microenvironment and Facilitating Nerve Regeneration

Liu

Shi

et al. 2023

Adv Healthcare Materials

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“…According to the recent statistics of the International Agency for Research on Cancer, breast cancer has become the most diagnosed cancer in both sexes [87]. Much attention has been paid to develop novel materials for breast cancer treatment [88][89][90][91].…”

Section: Breast Cancer Treatmentmentioning

confidence: 99%

Single-atom nanozymes: From bench to bedside

et al. 2022

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Single-atom nanozymes (SANs) are the new emerging catalytic nanomaterials with enzyme-mimetic activities, which have many extraordinary merits, such as low-cost preparation, maximum atom utilization, ideal catalytic activity, and optimized selectivity. With these advantages, SANs have received extensive research attention in the fields of chemistry, energy conversion, and environmental purification. Recently, a growing number of studies have shown the great promise of SANs in biological applications. In this article, we present the most recent developments of SANs in anti-infective treatment, cancer diagnosis and therapy, biosensing, and antioxidative therapy. This text is expected to better guide the readers to understand the current state and future clinical possibilities of SANs in medical applications.

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“…Moreover, in clinical practice, radiotherapy inevitably causes irreversible damage to normal tissues and cells [9][10][11]. Therefore, the development of radiotherapy sensitizers can greatly overcome the shortcomings of conventional radiotherapy and reduce the toxic side effects caused by conventional radiotherapy [12][13][14]. Currently, it has been found that many materials have the ability to enhance the sensitivity of tumor cells to X-rays, such as the small molecule paclitaxel [15][16][17] and metal complexes [18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Alleviating the hypoxic tumor microenvironment with MnO2-coated CeO2 nanoplatform for magnetic resonance imaging guided radiotherapy

Deng

Xue

et al. 2023

J Nanobiotechnol

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Background Radiotherapy is a commonly used tool in clinical practice to treat solid tumors. However, due to the unique microenvironment inside the tumor, such as high levels of GSH, overexpressed H2O2 and hypoxia, these factors can seriously affect the effectiveness of radiotherapy. Results Therefore, to further improve the efficiency of radiotherapy, a core–shell nanocomposite CeO2–MnO2 is designed as a novel radiosensitizer that can modulate the tumor microenvironment (TME) and thus improve the efficacy of radiation therapy. CeO2–MnO2 can act as a radiosensitizer to enhance X-ray absorption at the tumor site while triggering the response behavior associated with the tumor microenvironment. According to in vivo and in vitro experiments, the nanoparticles aggravate the killing effect on tumor cells by generating large amounts of ROS and disrupting the redox balance. In this process, the outer layer of MnO2 reacts with GSH and H2O2 in the tumor microenvironment to generate ROS and release oxygen, thus alleviating the hypoxic condition in the tumor area. Meanwhile, the manganese ions produced by degradation can enhance T1-weighted magnetic resonance imaging (MRI). In addition, CeO2–MnO2, due to its high atomic number oxide CeO2, releases a large number of electrons under the effect of radiotherapy, which further reacts with intracellular molecules to produce reactive oxygen species and enhances the killing effect on tumor cells, thus having the effect of radiotherapy sensitization. In conclusion, the nanomaterial CeO2–MnO2, as a novel radiosensitizer, greatly improves the efficiency of cancer radiation therapy by improving the lack of oxygen in tumor and responding to the tumor microenvironment, providing an effective strategy for the construction of nanosystem with radiosensitizing function. Conclusion In conclusion, the nanomaterial CeO2–MnO2, as a novel radiosensitizer, greatly improves the efficiency of cancer radiation therapy by improving the lack of oxygen in tumor and responding to the tumor microenvironment, providing an effective strategy for the construction of nanosystems with radiosensitizing function.

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Biomimetic multifunctional nanozymes enhanced radiosensitization for breast cancer via an X-ray triggered cascade reaction

Abstract: Radiotherapy was widely applied for breast cancer treatment in clinical, while how to improve the radiation sensitivity of tumor and protect normal tissues form radiation damage had drawn considerable attention....

Cited by 14 publications

References 30 publications

ROS‐Scavenging Hydrogels Synergize with Neural Stem Cells to Enhance Spinal Cord Injury Repair via Regulating Microenvironment and Facilitating Nerve Regeneration

ROS‐Scavenging Hydrogels Synergize with Neural Stem Cells to Enhance Spinal Cord Injury Repair via Regulating Microenvironment and Facilitating Nerve Regeneration

Single-atom nanozymes: From bench to bedside

Alleviating the hypoxic tumor microenvironment with MnO2-coated CeO2 nanoplatform for magnetic resonance imaging guided radiotherapy

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