Biomimetic nanocarriers harnessing microbial metabolites usher the path for brain disease therapy

Gong, Ying; Liu, Zhijun; Zhou, Piaopiao; Li, Jiahong; Miao, Yang-Bao

doi:10.1016/j.ntm.2023.100020

Cited by 7 publications

(4 citation statements)

References 318 publications

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“…BBB functions as the primary defense line between the circulation system and CNS, effectively preventing the infiltration of peripheral bacteria and/or their virulence factors into the brain ( Gong et al, 2023 ). Comprised primarily of brain microvascular endothelial cells (BMECs), astrocytes, pericytes, and a basement membrane, it safeguards cerebral integrity ( Nation et al, 2019 ).…”

Section: The Pathways Of Periodontal Pathogens Affecting Cnsmentioning

confidence: 99%

The oral-brain axis: can periodontal pathogens trigger the onset and progression of Alzheimer’s disease?

Li,

Wang,

Xiong

et al. 2024

Front. Microbiol.

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Alzheimer’s disease (AD) is the most prevalent form of dementia, characterized by a progressive cognitive decline. Sporadic AD, accounting for more than 95% of cases, may arise due to the influence of environmental factors. It was reported that periodontitis, a common oral ailment, shares several risk factors with AD, including advanced age, smoking, diabetes, and hypertension, among others. Periodontitis is an inflammatory disease triggered by dysbiosis of oral microorganisms, whereas Alzheimer’s disease is characterized by neuroinflammation. Many studies have indicated that chronic inflammation can instigate brain AD-related pathologies, including amyloid-β plaques, Tau protein hyperphosphorylation, neuroinflammation, and neurodegeneration. The potential involvement of periodontal pathogens and/or their virulence factors in the onset and progression of AD by the oral-brain axis has garnered significant attention among researchers with ongoing investigations. This review has updated the periodontal pathogens potentially associated with AD, elucidating their impact on the central nervous system, immune response, and related pathological processes in the brain to provide valuable insights for future research on the oral-brain axis.

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Section: The Pathways Of Periodontal Pathogens Affecting Cnsmentioning

confidence: 99%

The oral-brain axis: can periodontal pathogens trigger the onset and progression of Alzheimer’s disease?

Li,

Wang,

Xiong

et al. 2024

Front. Microbiol.

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“…Meanwhile, synthetic counterparts span a diverse array, embracing molecules, polymers (ranging from polymers to polymer micelles and hydrogels), as well as single-molecule nanoregulators like microemulsions, shell-nucleus nanostructures, porous solids, and nanotubes. These sophisticated entities predominantly serve catalytic functions, engage in drug delivery at the nano-level, and act as biosensors [ 101 – 103 ].…”

Section: Nanoregulator Design For Dynamic Restorationmentioning

confidence: 99%

De novo design of a nanoregulator for the dynamic restoration of ovarian tissue in cryopreservation and transplantation

Jiang,

Zhang,

et al. 2024

J Nanobiotechnol

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The cryopreservation and transplantation of ovarian tissue underscore its paramount importance in safeguarding reproductive capacity and ameliorating reproductive disorders. However, challenges persist in ovarian tissue cryopreservation and transplantation (OTC-T), including the risk of tissue damage and dysfunction. Consequently, there has been a compelling exploration into the realm of nanoregulators to refine and enhance these procedures. This review embarks on a meticulous examination of the intricate anatomical structure of the ovary and its microenvironment, thereby establishing a robust groundwork for the development of nanomodulators. It systematically categorizes nanoregulators and delves deeply into their functions and mechanisms, meticulously tailored for optimizing ovarian tissue cryopreservation and transplantation. Furthermore, the review imparts valuable insights into the practical applications and obstacles encountered in clinical settings associated with OTC-T. Moreover, the review advocates for the utilization of microbially derived nanomodulators as a potent therapeutic intervention in ovarian tissue cryopreservation. The progression of these approaches holds the promise of seamlessly integrating nanoregulators into OTC-T practices, thereby heralding a new era of expansive applications and auspicious prospects in this pivotal domain. Graphical Abstract

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“…242 SCFAs can even cross the blood-brain barrier. 243 Therefore, controlling the type and total amount of SCFAs in the colon may be a beneficial nutritional therapeutic strategy. Low-molecular weight (LMW) SCFAs coupled with polyethylene glycol (PEG) and polyethylene esters via ester bonds form amphiphilic block copolymers, which can spontaneously form micelles under aqueous conditions (Figure 12A).…”

Section: Nanosystems Based On Metabolites Of the Gut Microbiotamentioning

confidence: 99%

“…They can reach various organs and participate in the regulation of glucose homeostasis, immune response, metabolism, and epigenetic modification . SCFAs can even cross the blood-brain barrier . Therefore, controlling the type and total amount of SCFAs in the colon may be a beneficial nutritional therapeutic strategy.…”

Section: Representative Applications Of Bioinspired Therapeutic Platf...mentioning

confidence: 99%

Advanced Bioinspired Multifunctional Platforms Focusing on Gut Microbiota Regulation

Li,

Wang,

Lin

et al. 2024

ACS Nano

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Gut microbiota plays a crucial role in maintaining host homeostasis, impacting the progression and therapeutic outcomes of diseases, including inflammatory bowel disease, cancer, hepatic conditions, obesity, cardiovascular pathologies, and neurologic disorders, via immune, neural, and metabolic mechanisms. Hence, the gut microbiota is a promising target for disease therapy. The safety and precision of traditional microbiota regulation methods remain a challenge, which limits their widespread clinical application. This limitation has catalyzed a shift toward the development of multifunctional delivery systems that are predicated on microbiota modulation. Guided by bioinspired strategies, an extensive variety of naturally occurring materials and mechanisms have been emulated and harnessed for the construction of platforms aimed at the monitoring and modulation of gut microbiota. This review outlines the strategies and advantages of utilizing bioinspired principles in the design of gut microbiota intervention systems based on traditional regulation methods. Representative studies on the development of bioinspired therapeutic platforms are summarized, which are based on gut microbiota modulation to confer multiple pharmacological benefits for the synergistic management of diseases. The prospective avenues and inherent challenges associated with the adoption of bioinspired strategies in the refinement of gut microbiota modulation platforms are proposed to augment the efficacy of disease treatment.

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Biomimetic nanocarriers harnessing microbial metabolites usher the path for brain disease therapy

Cited by 7 publications

References 318 publications

The oral-brain axis: can periodontal pathogens trigger the onset and progression of Alzheimer’s disease?

The oral-brain axis: can periodontal pathogens trigger the onset and progression of Alzheimer’s disease?

De novo design of a nanoregulator for the dynamic restoration of ovarian tissue in cryopreservation and transplantation

Advanced Bioinspired Multifunctional Platforms Focusing on Gut Microbiota Regulation

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