Biomimetic Nanocomposites Camouflaged with Hybrid Cell Membranes for Accurate Therapy of Early‐Stage Glioma

Abstract

Glioma features high fatality rate and short survival time of patients due to its fast growth speed and high invasiveness, hence timely treatment of early‐stage glioma is extremely important. However, the blood brain barrier (BBB) severely prevents therapeutic agents from entering the brain; meanwhile, the non‐targeted distribution of agents always causes side effects to vulnerable cerebral tissues. Therefore, delivery systems that possess both BBB penetrability and precise glioma targeting ability are keenly desired. We herein proposed a hybrid cell membrane (HM) camouflage strategy to construct therapeutic nanocomposites, in which HM consisting of brain metastatic breast cancer cell membrane and glioma cell membrane was prepared with a simple membrane fusion pathway. By coating HM onto drug‐loaded nanoparticles, the as‐obtained biomimetic therapeutic agent (termed HMGINPs) inherited satisfying BBB penetrability and homologous glioma targeting ability simultaneously from the two source cells. HMGINPs exhibited good biocompatibility and superior therapeutic efficacy towards early‐stage glioma.

Cancer-Associated Fibroblast Mimetic AIE Probe for Precision Imaging-Guided Full-Cycle Management of Ovarian Cancer Surgery

“…Cell membrane coating technology is an emerging nanotechnology that can transfer the properties of cell membranes to other material surfaces, thus enabling the modification and functionalization of materials with promising applications. , The mimetic probes prepared from CAFs were able to avoid clearance by the reticuloendothelial system and improve the bioavailability of the probes while also providing good passive targeting (EPR effect) and active targeting (specific binding based on fibronectin and ITGA5). In vivo, the CAF-probe has an imaging signal-to-noise ratio of 8.6 for ovarian cancer, which can effectively distinguish ovarian cancer tissue from normal tissue.…”

Engineered Cell Membrane-Camouflaged Nanomaterials for Biomedical Applications

“…Additionally, the tumor cell membrane performs other functions; for instance, the surface receptors of the glioblastoma (GBM) membrane can interact with endothelial cell adhesion molecules, facilitating the crossing of the blood–brain barrier (BBB). Chi et al coated nanomedicines with the cell membranes of brain metastatic breast cancer MCF-7 and GBM U87-MG, demonstrating their ability to cross the BBB and target homologous tumors [ 35 ]. Similarly, Yan et al developed a reactive oxygen species (ROS)-responsive nanoparticle (HM-NPs@G) masked by a hybrid membrane consisting of cancer cells and mitochondria to target GBM mitochondria with the oxidative phosphorylation inhibitor Gboxin, which effectively prolonged the circulation time, facilitated the permeability of the BBB, and improved its accumulation at the GBM site ( Figure 3 ) [ 33 ].…”

“…the BBB and target homologous tumors [35]. Similarly, Yan et al developed a reactive oxygen species (ROS)-responsive nanoparticle (HM-NPs@G) masked by a hybrid membrane consisting of cancer cells and mitochondria to target GBM mitochondria with the oxidative phosphorylation inhibitor Gboxin, which effectively prolonged the circulation time, facilitated the permeability of the BBB, and improved its accumulation at the GBM site (Figure 3) [33].…”