Biomimetic Nanocomposites Camouflaged with Hybrid Cell Membranes for Accurate Therapy of Early‐Stage Glioma

Abstract

Glioma features high fatality rate and short survival time of patients due to its fast growth speed and high invasiveness, hence timely treatment of early‐stage glioma is extremely important. However, the blood brain barrier (BBB) severely prevents therapeutic agents from entering the brain; meanwhile, the non‐targeted distribution of agents always causes side effects to vulnerable cerebral tissues. Therefore, delivery systems that possess both BBB penetrability and precise glioma targeting ability are keenly desired. We herein proposed a hybrid cell membrane (HM) camouflage strategy to construct therapeutic nanocomposites, in which HM consisting of brain metastatic breast cancer cell membrane and glioma cell membrane was prepared with a simple membrane fusion pathway. By coating HM onto drug‐loaded nanoparticles, the as‐obtained biomimetic therapeutic agent (termed HMGINPs) inherited satisfying BBB penetrability and homologous glioma targeting ability simultaneously from the two source cells. HMGINPs exhibited good biocompatibility and superior therapeutic efficacy towards early‐stage glioma.

A Unique Approach: Biomimetic Graphdiyne-Based Nanoplatform to Treat Prostate Cancer by Combining Cuproptosis and Enhanced Chemodynamic Therapy

“…It has been reported that adhesion molecules (eg adhesion proteins and integrins) on the surface of cancer cell membranes can confer homologous recognition and homing properties to nanomaterials. 38–40 This result confirms that the improved antitumor effect of the nanomaterials can be attributed to the homotypic targeting ability of DCM@GDY-CuMOF@DOX.…”

Cell Membrane-Coated Biomimetic Nanoparticles in Cancer Treatment

“…A wide range of cell membrane combinations has been investigated for preparing Hym to encapsulate nanomaterials. Beyond the examples previously discussed, research has explored hybrids of cancer–cancer [ 91 ], DC–cancer [ 92 ], RBC–PLT [ 139 ], mitochondria–cancer [ 140 ], bacteria–cancer [ 141 ], and embryonic–bacteria [ 142 ], among others.…”

Cell Membrane Biomimetic Nano-Delivery Systems for Cancer Therapy

“…Chi et al proposed a hybrid cell membrane (HM) camouflage strategy consisting of brain metastatic breast cancer cell membranes MCF-7 cell membrane (MM) and U87-MG cell membrane (UM). The nano-delivery system has BBB cross-over capability and homologous tumor-targeting capability inherited from two cell membranes of origin [ 141 ]. In vitro and in vivo investigations have been carried out on the ability of HMGINPs to cross the blood–brain barrier ( Figure 9 G).…”

“…Long circulation [139] Leukocyte-cancer cell Immune escaping Tumor-targeting [140,150] Cancer-cancer Transendothelial migration Tumor-targeting [141] Although CMBNDS has shown promising therapeutic prospects in cancer diagnosis and treatment, there are still some remaining problems in the development and clinical application of CMBNDS. Here we summarize the problems encountered in the development and clinical application of CMBNDS.…”