Biomimetic Nanostructured Materials:  Inherent Reversible Stabilization of Polypeptide Microcapsules

Haynie, Donald T.; Palath, Naveen; Liu, Yang; Li, Bingyun; Pargaonkar, Nikhil

doi:10.1021/la047833d

Cited by 80 publications

(75 citation statements)

References 18 publications

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“…Another interesting development was the synthesis of disulfide cross-linked polymer capsules [55]. The disulfide bonds confer enhanced stability to hydrogen-bonded multilayer thin films at physiological pH.…”

Section: Nanocapsulesmentioning

confidence: 99%

Nanostructured materials for applications in drug delivery and tissue engineering

Goldberg

Langer

Jia

2007

Journal of Biomaterials Science, Polymer Edition

954

554

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Research in the areas of drug delivery and tissue engineering has witnessed tremendous progress in recent years due to their unlimited potential to improve human health. Meanwhile, the development of nanotechnology provides opportunities to characterize, manipulate and organize matter systematically at the nanometer scale. Biomaterials with nano-scale organizations have been used as controlled release reservoirs for drug delivery and artificial matrices for tissue engineering. Drug-delivery systems can be synthesized with controlled composition, shape, size and morphology. Their surface properties can be manipulated to increase solubility, immunocompatibility and cellular uptake. The limitations of current drug delivery systems include suboptimal bioavailability, limited effective targeting and potential cytotoxicity. Promising and versatile nano-scale drug-delivery systems include nanoparticles, nanocapsules, nanotubes, nanogels and dendrimers. They can be used to deliver both small-molecule drugs and various classes of biomacromolecules, such as peptides, proteins, plasmid DNA and synthetic oligodeoxynucleotides. Whereas traditional tissue-engineering scaffolds were based on hydrolytically degradable macroporous materials, current approaches emphasize the control over cell behaviors and tissue formation by nano-scale topography that closely mimics the natural extracellular matrix (ECM). The understanding that the natural ECM is a multifunctional nanocomposite motivated researchers to develop nanofibrous scaffolds through electrospinning or self-assembly. Nanocomposites containing nanocrystals have been shown to elicit active bone growth. Drug delivery and tissue engineering are closely related fields. In fact, tissue engineering can be viewed as a special case of drug delivery where the goal is to accomplish controlled delivery of mammalian cells. Controlled release of therapeutic factors in turn will enhance the efficacy of tissue engineering. From a materials point of view, both the drug-delivery vehicles and tissue-engineering scaffolds need to be biocompatible and biodegradable. The biological functions of encapsulated drugs and cells can be dramatically enhanced by designing biomaterials with controlled organizations at the nanometer scale. This review summarizes the most recent development in utilizing nanostructured materials for applications in drug delivery and tissue engineering.

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Section: Nanocapsulesmentioning

confidence: 99%

Nanostructured materials for applications in drug delivery and tissue engineering

Goldberg

Langer

Jia

2007

Journal of Biomaterials Science, Polymer Edition

954

554

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“…[29,30] Below, we highlight three recent reports based on this general approach that demonstrate triggered film deconstruction and the release of functional proteins and DNA under physiological conditions.…”

Section: Reduction Of Disulfide Bondsmentioning

confidence: 99%

Peeling Back the Layers: Controlled Erosion and Triggered Disassembly of Multilayered Polyelectrolyte Thin Films

2007

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Methods for the layer‐by‐layer deposition of oppositely charged polymers on surfaces can be used to assemble thin multilayered films using a broad range of natural, synthetic, and biologically relevant materials. These methods also permit precise, nanometer‐scale control over the compositions and internal structures of multicomponent assemblies. Provided that the individual components of these materials are selected or designed appropriately, these methods provide tantalizing new opportunities to design thin films and coatings that provide spatial, temporal, or active control over the release of one or several different agents from surfaces. The last two years have seen a significant increase in reports describing the development of new chemical, physical, and biomolecular approaches to the controlled erosion, triggered disassembly, or general deconstruction of multilayered polymer films. In this Progress Report, we highlight recent work from our laboratory and several other groups toward the design of ultrathin multilayered assemblies that i) permit broad, tunable, and sophisticated control over film erosion, and ii) provide new opportunities for the localized release of macromolecular therapeutics, such as DNA and proteins, from surfaces.

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“…[9][10][11][12][13][14] The assembled capsules have well-controlled size, shape, and wall thickness. The wall composition can be readily changed to adjust their physicochemical properties and permeability.…”

mentioning

confidence: 99%

Adenosine Triphosphate Biosynthesis Catalyzed by F_oF₁ ATP Synthase Assembled in Polymer Microcapsules

Wang

et al. 2007

Angew Chem Int Ed

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Biomimetic Nanostructured Materials: Inherent Reversible Stabilization of Polypeptide Microcapsules

Cited by 80 publications

References 18 publications

Nanostructured materials for applications in drug delivery and tissue engineering

Nanostructured materials for applications in drug delivery and tissue engineering

Peeling Back the Layers: Controlled Erosion and Triggered Disassembly of Multilayered Polyelectrolyte Thin Films

Adenosine Triphosphate Biosynthesis Catalyzed by F_oF₁ ATP Synthase Assembled in Polymer Microcapsules

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Biomimetic Nanostructured Materials: Inherent Reversible Stabilization of Polypeptide Microcapsules

Cited by 80 publications

References 18 publications

Nanostructured materials for applications in drug delivery and tissue engineering

Nanostructured materials for applications in drug delivery and tissue engineering

Peeling Back the Layers: Controlled Erosion and Triggered Disassembly of Multilayered Polyelectrolyte Thin Films

Adenosine Triphosphate Biosynthesis Catalyzed by FoF1 ATP Synthase Assembled in Polymer Microcapsules

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Adenosine Triphosphate Biosynthesis Catalyzed by F_oF₁ ATP Synthase Assembled in Polymer Microcapsules