Biomimetic Nanostructures by Electrospinning and Electrospraying

Vatankhah, Elham; Prabhakaran, Molamma P.; Ramakrishna, Seeram

doi:10.1002/9781118540640.ch8

Cited by 4 publications

(2 citation statements)

References 88 publications

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“…6 A nanofibrous nonwoven matrix electrospun from natural and/or synthetic polymers is among the most promising biomaterials for scaffolding. 7 Here in this study, we utilized a three-layered vascular graft fabricated by electrospinning to mimic natural architecture of an artery. Polycaprolactone (PCL), collagen type IV, and poly(L-lactic acid) (PLLA) were electrospun sequentially in order to produce inner, intermediate, and outer layers of a biodegradable tubular scaffold.…”

Section: Introductionmentioning

confidence: 99%

In vitro hemocompatibility and cytocompatibility of a three-layered vascular scaffold fabricated by sequential electrospinning of PCL, collagen, and PLLA nanofibers

et al. 2016

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Aiming to mimic a blood vessel structurally, morphologically, and mechanically, a sequential electrospinning technique using a small diameter mandrel collector was performed and a three-layered tubular scaffold composed of nanofibers of polycaprolactone, collagen, and poly(l-lactic acid) as inner, intermediate, and outer layers, respectively, was developed. Biological performances of the scaffold in terms of compatibility with blood and endothelial cells were assessed to get some insights into its potential use as a tissue engineered small-diameter vascular replacement compared to an expanded polytetrafluoroethylene vascular graft. Due to direct contact of the blood and endothelial cells with inner surface of the scaffold, polycaprolactone fibers were characterized using SEM, water contact angle measurement, and ATR-FTIR. Despite similar surface wettability of the electrospun scaffold and the expanded polytetrafluoroethylene graft, the three-layered scaffold significantly reduced platelet adhesion and hemolysis ratio compared to expanded polytetrafluoroethylene graft while comparable blood clotting profiles were observed for both electrospun scaffold and expanded polytetrafluoroethylene graft. However, inflammatory response to nanofibrous surface of the scaffold was reduced compared to expanded polytetrafluoroethylene graft. The electrospun scaffold also presented a significantly more supportive substrate for endothelialization than the expanded polytetrafluoroethylene graft. The results described herein suggested that the three-layered scaffold has superior biological properties compared to an expanded polytetrafluoroethylene graft for vascular tissue engineering.

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Section: Introductionmentioning

confidence: 99%

In vitro hemocompatibility and cytocompatibility of a three-layered vascular scaffold fabricated by sequential electrospinning of PCL, collagen, and PLLA nanofibers

et al. 2016

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“…In this work, the group processed Jurkat cells obtaining deposited droplets in the range of tens of micrometers. BES does not influence cell viability, which has been verified on cell lines such as sperm or stem cells [101][102][103][104][105]. This methodology has been proven to be a useful tool for cell encapsulation, the controlled deposition of cells on planar surfaces, drug delivery, and immunotherapy [102,106].…”

Section: Cell-electrospinning (Ce) and Bio-electrospraying (Bes)mentioning

confidence: 82%

Emerging Biofabrication Techniques: A Review on Natural Polymers for Biomedical Applications

2021

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Natural polymers have been widely used for biomedical applications in recent decades. They offer the advantages of resembling the extracellular matrix of native tissues and retaining biochemical cues and properties necessary to enhance their biocompatibility, so they usually improve the cellular attachment and behavior and avoid immunological reactions. Moreover, they offer a rapid degradability through natural enzymatic or chemical processes. However, natural polymers present poor mechanical strength, which frequently makes the manipulation processes difficult. Recent advances in biofabrication, 3D printing, microfluidics, and cell-electrospinning allow the manufacturing of complex natural polymer matrixes with biophysical and structural properties similar to those of the extracellular matrix. In addition, these techniques offer the possibility of incorporating different cell lines into the fabrication process, a revolutionary strategy broadly explored in recent years to produce cell-laden scaffolds that can better mimic the properties of functional tissues. In this review, the use of 3D printing, microfluidics, and electrospinning approaches has been extensively investigated for the biofabrication of naturally derived polymer scaffolds with encapsulated cells intended for biomedical applications (e.g., cell therapies, bone and dental grafts, cardiovascular or musculoskeletal tissue regeneration, and wound healing).

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Experimental investigation into size and sphericity of alginate micro-beads produced by electrospraying technique: Operational condition optimization

Partovinia

Vatankhah

2019

Carbohydrate Polymers

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Biomimetic Nanostructures by Electrospinning and Electrospraying

Cited by 4 publications

References 88 publications

In vitro hemocompatibility and cytocompatibility of a three-layered vascular scaffold fabricated by sequential electrospinning of PCL, collagen, and PLLA nanofibers

In vitro hemocompatibility and cytocompatibility of a three-layered vascular scaffold fabricated by sequential electrospinning of PCL, collagen, and PLLA nanofibers

Emerging Biofabrication Techniques: A Review on Natural Polymers for Biomedical Applications

Experimental investigation into size and sphericity of alginate micro-beads produced by electrospraying technique: Operational condition optimization

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