Biomimetic osteogenic peptide with mussel adhesion and osteoimmunomodulatory functions to ameliorate interfacial osseointegration under chronic inflammation

Bai, Jiaxiang; Wang, Huaiyu; Chen, Hao; Ge, Gaoran; Wang, Miao; Gao, Ang; Tong, Liping; Xu, Yaozeng; Yang, Huiling; Pan, Guoqing; Chu, Paul K.; Geng, Dechun

doi:10.1016/j.biomaterials.2020.120197

Cited by 125 publications

(95 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cell function is closely related to the immediate microenvironment and is influenced by many factors including inflammatory mediators that are critical in affecting regenerative outcomes [ 44 ]. Notably, failure to resolve the foreign body inflammatory response typically leads to granulation (formation of connective tissue) and fibrotic capsule formation around the implant resulting in impaired outcomes [ 45 ].…”

Section: Resultsmentioning

confidence: 99%

Synergistic anti-inflammatory and osteogenic n-HA/resveratrol/chitosan composite microspheres for osteoporotic bone regeneration

et al. 2021

Bioactive Materials

View full text Add to dashboard Cite

The development of functional materials for osteoporosis is ultimately required for bone remodeling. However, grafts were accompanied by increasing pro-inflammatory cytokines that impaired bone formation. In this work, nano-hydroxyapatite (n-HA)/resveratrol (Res)/chitosan (CS) composite microspheres were designed to create a beneficial microenvironment and help improve the osteogenesis by local sustained release of Res. Study of in vitro release confirmed the feasibility of n-HA/Res/CS microspheres for controlled Res release. Notably, microspheres had anti-inflammatory activity evidenced by the decreased expression of pro-inflammatory cytokines TNF-α, IL-1β and iNOS in RAW264.7 cells in a dose dependent manner. Further, enhanced adhesion and proliferation of BMSCs seeded onto microspheres demonstrated that composite microspheres were conducive to cell growth. The ability to enhance osteo-differentiation was supported by up-regulation of Runx2, ALP, Col-1 and OCN, and substantial mineralization in osteogenic medium. When implanted into bone defects in the osteoporotic rat femoral condyles, enhanced entochondrostosis and bone regeneration suggested that the n-HA/Res/CS composite microspheres were more favorable for impaired fracture healing. The results indicated that optimized n-HA/Res/CS composite microspheres could serve as promising multifunctional fillers for osteoporotic bone defect/fracture treatment.

show abstract

Section: Resultsmentioning

confidence: 99%

Synergistic anti-inflammatory and osteogenic n-HA/resveratrol/chitosan composite microspheres for osteoporotic bone regeneration

et al. 2021

Bioactive Materials

View full text Add to dashboard Cite

show abstract

“…Osteogenic peptide‐coated titanium implant demonstrated the potential to attenuate the inflammation response of M1 macrophages in vitro (RAW 264.7) and in vivo (rat model). [ 323 ] With osteoimmunomodulatory promotion on M2 macrophage polarization, the bioactive peptide coating could effectively inhibit osteoclastogenesis and ameliorate bone‐implant osseointegration in the presence of a chronic inflammation. Herein, we mainly focus on the biomaterial‐assisted targeted immunomodulation of monocytes/macrophages in tissue repair and regeneration immunotherapy, and some other representative studies/strategies reported are also summarized in Table 5 .…”

Section: Immunoengineering Applicationsmentioning

confidence: 99%

Tailoring Materials for Modulation of Macrophage Fate

et al. 2021

View full text Add to dashboard Cite

Human immune system acts as a pivotal role in the tissue homeostasis and disease progression. Immunomodulatory biomaterials that can manipulate innate immunity and adaptive immunity hold great promise for a broad range of prophylactic and therapeutic purposes. This review is focused on the design strategies and principles of immunomodulatory biomaterials from the standpoint of materials science to regulate macrophage fate, such as activation, polarization, adhesion, migration, proliferation, and secretion. It offers a comprehensive survey and discussion on the tunability of material designs regarding physical, chemical, biological, and dynamic cues for modulating macrophage immune response. The range of such tailorable cues encompasses surface properties, surface topography, materials mechanics, materials composition, and materials dynamics. The representative immunoengineering applications selected herein demonstrate how macrophage-immunomodulating biomaterials are being exploited for cancer immunotherapy, infection immunotherapy, tissue regeneration, inflammation resolution, and vaccination. A perspective on the future research directions of immunoregulatory biomaterials is also provided.

show abstract

“…However, although we and others have demonstrated to control macrophage activities on the biomaterial surface, [ 39–41 ] a dynamic and smart “on–off” switch of macrophage‐mediated inflammation—in response to the regenerative signals—remains poorly accomplished. [ 26 ] For example, numerous excellent methods effectively stimulate macrophages to produce a desirable array of inflammatory signals (e.g., using macrophage‐stimulating coating); [ 42–44 ] or uncover the impact of surface geometry on macrophage phenotypic change (e.g., with micro‐/nanopatterning); [ 45–47 ] or induce a pro‐ to anti‐inflammatory change at arbitrary timepoints (e.g., through sequential release of cytokines). [ 48–50 ] Nevertheless, it remains an unmet goal to turn on and off the activities of inflammatory macrophages on implants in vivo in accordance with the healing progress.…”

Section: Introductionmentioning

confidence: 99%

Switching On and Off Macrophages by a “Bridge‐Burning” Coating Improves Bone‐Implant Integration under Osteoporosis

Wang

Niu

Tian

et al. 2020

Adv Funct Materials

View full text Add to dashboard Cite

Osteoporosis poses substantial challenges for biomaterials implantation. New approaches to improve bone‐implant integration should resolve the fundamental dilemma of inflammation—proper inflammation is required at early stages but should be suppressed later for better healing, especially under osteoporosis. However, precisely switching on and off inflammation around implants in vivo remains unachieved. To address this challenge, a “bridge‐burning” coating material that comprises a macrophage‐activating glycan covalently crosslinked by a macrophage‐eliminating bisphosphonate to titanium implant surface is designed. Upon implantation, the glycan instructs host macrophages to release pro‐osteogenic cytokines (“switch‐on”), promoting bone cell differentiation. Later, increasingly mature bone cells secrete alkaline phosphatase to cleave the glycan‐bisphosphonate complexes from the implant, which in turn selectively kill the proinflammatory macrophages (“switch‐off”) that have completed their contribution—hence in the manner of “burning bridges”—to promote healing. In vivo examination in an osteoporotic rat model demonstrates that this coating significantly enhances bone‐implant integration (88.4% higher contact ratio) through modulating local inflammatory niches. In summary, a bioresponsive, endogenously triggered, smart coating material is developed to sequentially harness and abolish the power of inflammation to improve osseointegration under osteoporosis, which represents a new strategy for designing immunomodulatory biomaterials for tissue regeneration.

show abstract

Biomimetic osteogenic peptide with mussel adhesion and osteoimmunomodulatory functions to ameliorate interfacial osseointegration under chronic inflammation

Cited by 125 publications

References 65 publications

Synergistic anti-inflammatory and osteogenic n-HA/resveratrol/chitosan composite microspheres for osteoporotic bone regeneration

Synergistic anti-inflammatory and osteogenic n-HA/resveratrol/chitosan composite microspheres for osteoporotic bone regeneration

Tailoring Materials for Modulation of Macrophage Fate

Switching On and Off Macrophages by a “Bridge‐Burning” Coating Improves Bone‐Implant Integration under Osteoporosis

Contact Info

Product

Resources

About