Biomimetic porous Mg with tunable mechanical properties and biodegradation rates for bone regeneration

Kang, Min Ho; Lee, Hyun; Jang, Tae‐Sik; Seong, Yun Jeong; Kim, Hyoun Ee; Koh, Young Hag; Song, Juha; Jung, Hyun‐Do

doi:10.1016/j.actbio.2018.11.045

Cited by 78 publications

(37 citation statements)

References 80 publications

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“…However, the 20 vol% of HA in HA/PLLA sample deteriorated the mechanical properties, which showed similar results to those reported in previous studies [ 26 , 27 ]. It should be noted that patterned HA/PLLA maintained tensile properties and did not show a significant difference when compared with those of pure PLLA, and these values compare favorably with the tensile strength (−50 MPa) and stiffness (3–20 GPa) of natural cortical bone in transverse loading [ 28 ].…”

Section: Resultsmentioning

confidence: 99%

Enhanced Bioactivity of Micropatterned Hydroxyapatite Embedded Poly(L-lactic) Acid for a Load-Bearing Implant

et al. 2020

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Poly(L-lactic) acid (PLLA) is among the most promising polymers for bone fixation, repair, and tissue engineering due to its biodegradability and relatively good mechanical strength. Despite these beneficial characteristics, its poor bioactivity often requires incorporation of bioactive ceramic materials. A bioresorbable composite made of PLLA and hydroxyapatite (HA) may improve biocompatibility but typically causes deterioration in mechanical properties, and bioactive coatings inevitably carry a risk of coating delamination. Therefore, in this study, we embedded micropatterned HA on the surface of PLLA to improve bioactivity while eliminating the risk of HA delamination. An HA pattern was successfully embedded in a PLLA matrix without degeneration of the matrix’s mechanical properties, thanks to a transfer technique involving conversion of Mg to HA. Furthermore, patterned HA/PLLA’s biological response outperformed that of pure PLLA. These results confirm patterned HA/PLLA as a candidate for wide acceptance in biodegradable load-bearing implant applications.

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Section: Resultsmentioning

confidence: 99%

Enhanced Bioactivity of Micropatterned Hydroxyapatite Embedded Poly(L-lactic) Acid for a Load-Bearing Implant

et al. 2020

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“…In line with the increasing interest in novel biodegradable metallic scaffolds, XCT has shown good potential to evaluate the microarchitecture of Mg-based scaffolds showing both porosity and pore size in the optimal range for bone ingrowth Kang et al, 2019;Parai & Bandyopadhyay-Ghosh, 2019). demonstrate d the capability of XCT to evaluate the corrosion of Mg-based scaffolds over time, enabling the quantification of volume/mass loss and surface degradation.…”

Section: Xct Characterisation Of Scaffolds and Biomaterialsmentioning

confidence: 93%

“…In line with the increasing interest in novel biodegradable metallic scaffolds, XCT has shown good potential to evaluate the microarchitecture of Mg‐based scaffolds showing both porosity and pore size in the optimal range for bone ingrowth (Li et al ., ; Kang et al ., ; Parai & Bandyopadhyay‐Ghosh, ). Li et al .…”

Section: Xct Characterisation Of Scaffolds and Biomaterialsmentioning

confidence: 99%

“…Novel designs of porous Mg biodegradable scaffolds aimed at mimicking the cortical and trabecular bone structure (Fig. 3) by a combination of a dense and porous regions, thus resulting in an enhancement of the mechanical properties and therefore being promising to load-bearing applications (Kang et al, 2019).…”

Section: Xct Characterisation Of Scaffolds and Biomaterialsmentioning

confidence: 99%

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Applications of X‐ray computed tomography for the evaluation of biomaterial‐mediated bone regeneration in critical‐sized defects

Fernández

Witte²,

Tozzi

2019

Journal of Microscopy

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Bone as such displays an intrinsic regenerative potential following fracture; however, this capacity is limited with large bone defects that cannot heal spontaneously. The management of critical‐sized bone defects remains a major clinical and socioeconomic need with osteoregenerative biomaterials constantly under development aiming at promoting and enhancing bone healing. X‐ray computed tomography (XCT) has become a standard and essential tool for quantifying structure–function relationships in bone and biomaterials, facilitating the development of novel bone tissue engineering strategies. This paper presents recent advancements in XCT analysis of biomaterial‐mediated bone regeneration. As a noninvasive and nondestructive technique, XCT allows for qualitative and quantitative evaluation of three‐dimensional (3D) scaffolds and biomaterial microarchitecture, bone growth into the scaffold as well as the 3D characterisation of biomaterial degradation and bone regeneration in vitro and in vivo. Furthermore, in combination with in situ mechanical testing and digital volume correlation (DVC), XCT demonstrated its potential to better understand the bone–biomaterial interactions and local mechanics of bone regeneration during the healing process in relation to the regeneration achieved in vivo, which will likely provide valuable knowledge for the development and optimisation of novel osteoregenerative biomaterials. Lay Description Bone, being a dynamically adaptable material, displays excellent regenerative properties following fracture. However, the self‐healing capacity of bone becomes more difficult with large bone defects. Those defects are common and occur in many clinical situations; hence, biomaterials are mostly used to restore both bone structure and function in the defect site. X‐ray computed tomography (XCT) is a powerful tool to evaluate bone regeneration in critical‐sized defects after the implantation of biomaterials, allowing to an improved understanding of the regeneration process following different bone tissue engineering approaches. This paper focuses on recent advancements in XCT analysis to characterise biomaterial‐mediated bone regeneration in critical‐sized defects. XCT supports three‐dimensional (3D) analysis of biomaterials, scaffolds and regenerated bone microarchitecture, as well as bone ingrowth into the scaffold. As a nondestructive technique, XCT allows for a 3D characterisation of biomaterial degradation and bone regeneration over time. In addition, XCT combined with in situ mechanical experiments and digital volume correlation (DVC) provides a 3D evaluation and quantification of bone–biomaterial interactions and deformation mechanisms during the regeneration process. This remains essential for the development and enhancement of novel biomaterials able to produce bone that is comparable with the native tissue they aim to replace.

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“…Metal ions are featured with their intrinsic bioactivity for satisfying different biomedical application requirements. [ 110–118 ] For instance, Ca 2+ ions are the important component of bone, signifying that CaO 2 nanoparticles might be applicable for tissue engineering. [ 119,120 ] Based on the consideration that CaO 2 nanoparticles are typically designed for tumor‐therapeutic purposes, we recently loaded CaO 2 nanoparticles into the matrix of 3D printing akermanite scaffold with the simultaneously integrated magnetic Fe 3 O 4 nanoparticles (designated as AKT‐Fe 3 O 4 ‐CaO 2 ), which exerted the specific functionality for osteosarcoma treatment ( Figure ).…”

Section: Metal Peroxide Nanoparticles For Tissue Regenerationmentioning

confidence: 99%

Chemoreactive Nanotherapeutics by Metal Peroxide Based Nanomedicine

Qian

et al. 2020

Advanced Science

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The advances of nanobiotechnology and nanomedicine enable the triggering of in situ chemical reactions in disease microenvironment for achieving disease-specific nanotherapeutics with both intriguing therapeutic efficacy and mitigated side effects. Metal peroxide based nanoparticles, as one of the important but generally ignored categories of metal-involved nanosystems, can function as the solid precursors to produce oxygen (O 2 ) and hydrogen peroxide (H 2 O 2 ) through simple chemical reactions, both of which are the important chemical species for enhancing the therapeutic outcome of versatile modalities, accompanied with the unique bioactivity of metal ion based components. This progress report summarizes and discusses the most representative paradigms of metal peroxides in chemoreactive nanomedicine, including copper peroxide (CuO 2 ), calcium peroxide (CaO 2 ), magnesium peroxide (MgO 2 ), zinc peroxide (ZnO 2 ), barium peroxide (BaO 2 ), and titanium peroxide (TiO x ) nanosystems. Their reactions and corresponding products have been broadly explored in versatile disease treatments, including catalytic nanotherapeutics, photodynamic therapy, radiation therapy, antibacterial infection, tissue regeneration, and some synergistically therapeutic applications. This progress report particularly focuses on the underlying reaction mechanisms on enhancing the therapeutic efficacy of these modalities, accompanied with the discussion on their biological effects and biosafety. The existing gap between fundamental research and clinical translation of these metal peroxide based nanotherapeutic technologies is finally discussed in depth.

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Biomimetic porous Mg with tunable mechanical properties and biodegradation rates for bone regeneration

Cited by 78 publications

References 80 publications

Enhanced Bioactivity of Micropatterned Hydroxyapatite Embedded Poly(L-lactic) Acid for a Load-Bearing Implant

Enhanced Bioactivity of Micropatterned Hydroxyapatite Embedded Poly(L-lactic) Acid for a Load-Bearing Implant

Applications of X‐ray computed tomography for the evaluation of biomaterial‐mediated bone regeneration in critical‐sized defects

Chemoreactive Nanotherapeutics by Metal Peroxide Based Nanomedicine

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