Biomimetic processing of bioactive interface on silicon substrates

Chong, Ser Choong; Loo, Say Chye Joachim; Lee, Pooi See; Ma, Jan

doi:10.1002/jbm.b.30955

Cited by 3 publications

(2 citation statements)

References 47 publications

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“…If the mechanical properties of the substitute material and the tissue to be augmented significantly differ from each other, the interface plays an important role, and a good bonding could be the key for reliable mechanical performance. The crystals that grew on PEGda25POSS75, PEGda50POSS50 and PEGda75POSS25 all had a flake-like spherical morphology indicating that a CP phase was formed on their surfaces [51,52]. A precipitate could also be seen on PEGda100POSS0 indicating that the CP phase was also formed here, whereas no growth was observed on PEGda0POSS100 or on the PMMA samples.…”

Section: Discussionmentioning

confidence: 93%

Polyhedral oligomeric silsesquioxane (POSS)–poly(ethylene glycol) (PEG) hybrids as injectable biomaterials

Engstrand

López²,

Engqvist³

et al. 2012

Biomed. Mater.

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One of the major issues with the currently available injectable biomaterials for hard tissue replacement is the mismatch between their mechanical properties and those of the surrounding bone. Hybrid bone cements that combine the benefits of tough polymeric and bioactive ceramic materials could become a good alternative. In this work, polyhedral oligomeric silsesquioxane (POSS) was copolymerized with poly(ethylene glycol) (PEG) to form injectable in situ cross-linkable hybrid cements. The hybrids were characterized in terms of their mechanical, rheological, handling and in vitro bioactive properties. The results indicated that hybridization improves the mechanical and bioactive properties of POSS and PEG. The Young moduli of the hybrids were lower than those of commercial cements and more similar to those of cancellous bone. Furthermore, the strength of the hybrids was similar to that of commercial cements. Calcium deficient hydroxyapatite grew on the surface of the hybrids after 28 days in PBS, indicating bioactivity. The study showed that PEG–POSS-based hybrid materials are a promising alternative to commercial bone cements.

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Section: Discussionmentioning

confidence: 93%

Polyhedral oligomeric silsesquioxane (POSS)–poly(ethylene glycol) (PEG) hybrids as injectable biomaterials

Engstrand

López²,

Engqvist³

et al. 2012

Biomed. Mater.

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show abstract

“…However, the bioactivity and biocompatibility of Si-based materials is still relatively not well understood. Various attempts were 18 In this study, it was hypothesized that nanotopographical modification of Si surfaces had strong effects on cellular interactions. The bioactivity and bone bonding ability of Si could be enhanced by altered surface nanotopography.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Si Nano-Columns in 2-D and 3-D on Cellular Behaviour: Nanotopography-Induced CaP Deposition from Differentiating Mesenchymal Stem Cells

Guvendik

Trabzon²,

Ramazanoğlu³

2011

J. Nanosci. Nanotech.

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Si nano-columns were deposited in 2-D and 3-D in the form of well-defined geometries by physical vapor deposition. The films were grown by e-beam evaporation with an angle between source and substrate. The Si nano-columns were deposited in the shape of spiral with two different incoming atomic flux angle so that the manipulation of nano-columns in 3-D (out-of-plane) was obtained. The Si nano-columns were also grown as vertical stick with square, triangle and linear cross sections in 2D (in-plane). Rat bone marrow mesenchymal stem cells (MSCs) were cultured on these different Si nanosurfaces. MTS assay was carried out to determine the cell proliferation and viability based on different nanotopographies. For the evaluation of cell distribution and morphology, a SEM (Scanning Electron Microscopy) analysis was performed. Any CaP deposition on Si nanosurfaces was observed using energy dispersive X-Ray spectroscopy in SEM (SEM-EDX). After 4 days of culture, there was a higher value of cell proliferation on square columns and spiral Si nano-columns grown with 85 degrees of incoming atomic flux. The cell attachment and spreading was also affected by the geometry of Si nano-columns. While there were still cells showing round/spherical morphology with minimal spreading on conventional Si surfaces, most of the cells cultured on different Si nanotopographies attached on the surface and displayed flattened morphology, especially on the square columns surface. Moreover, CaP deposition was discovered on square columns and spiral films with 85 degrees substrate angle. So, it can be concluded that there is a clear correlation between cell responses and nano-sized geometry on Si surface and it is possible to induce cellular differentiation and CaP formation in certain geometrical constraints.

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Surface preparation techniques for biomedical applications

Wang

2012

Coatings for Biomedical Applications

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Biomimetic processing of bioactive interface on silicon substrates

Cited by 3 publications

References 47 publications

Polyhedral oligomeric silsesquioxane (POSS)–poly(ethylene glycol) (PEG) hybrids as injectable biomaterials

Polyhedral oligomeric silsesquioxane (POSS)–poly(ethylene glycol) (PEG) hybrids as injectable biomaterials

The Effect of Si Nano-Columns in 2-D and 3-D on Cellular Behaviour: Nanotopography-Induced CaP Deposition from Differentiating Mesenchymal Stem Cells

Surface preparation techniques for biomedical applications

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