Biomimetic smart nanoplatform for dual imaging-guided synergistic cancer therapy

Shen, Yanfei; Fang, Zhengzou; Yang, Erli; Du, Ying; Gao, Daqing; Wu, Guoqiu; Zhang, Yuanjian

doi:10.1039/d1tb02306c

Cited by 30 publications

(12 citation statements)

References 65 publications

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“…Erythrocyte membrane (EM) vesicles were obtained according to the previous methods with some modification [ 24 ]. Firstly, erythrocytes were collected from BALB/c mice fresh blood and washed with PBS for several times to remove plasma and unwanted cells until the supernatant became colorless.…”

Section: Methodsmentioning

confidence: 99%

H2O2/pH Dual-Responsive Biomimetic Nanoenzyme Drugs Delivery System for Enhanced Tumor Photodynamic Therapy

Yan

et al. 2022

Nanoscale Res Lett

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Phototherapy has been recognized as a photochemical process to treat tumor via induce cancer cells necrosis and death, with minimal invasiveness, higher selectivity, and few side effects. However, the therapy effects of phototherapy are often compromised by the hypoxia, high levels of hydrogen peroxide, and glutathione of tumor microenvironment (TME). Therefore, we constructed a catalase-like activity bionic metal–organic framework drugs delivery system (FA-EM@MnO2/ZIF-8/ICG) with tumor microenvironment controllable releasing. In this system, photosensitizer indocyanine green (ICG) was introduced into zeolite imidazole salt skeleton 8 (ZIF-8) by one-step methods, forming ZIF-8/ICG nano-platform, which can effectively avoid ICG-induced phototoxicity and aggregation-induced quenching during transport. MnO2 with catalase-like activity was coated on the surface of ZIF-8/ICG nano-platform, which made it have the ability of self-supplying O2 under the condition of H2O2 in TME. Exposure under near-infrared light can alleviate the anoxic TME, thus improving the phototherapy efficiency. In addition, folate-functionalized erythrocyte membrane is coated on the surface of MnO2/ZIF-8/ICG, which can endow FA-EM@MnO2/ZIF-8/ICG with the ability of targeted drug administration and immune elimination avoidance. Therefore, FA-EM@MnO2/ZIF-8/ICG nano-platform has the catalase-like activity, which can alleviate the oxidative stress state of TME and provide a beneficial environment for photodynamic therapy of tumor.

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Section: Methodsmentioning

confidence: 99%

H2O2/pH Dual-Responsive Biomimetic Nanoenzyme Drugs Delivery System for Enhanced Tumor Photodynamic Therapy

Yan

et al. 2022

Nanoscale Res Lett

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“…Successful application of magnetically responsive nanoplatforms includes encapsulation/immobilization of therapeutic agents into magnetic-responsive nanoplatforms, injection of the magnetic stimuli-responsive nanoplatforms into the body and taking advantage of external magnetic fields to recruit and activate the magnetic stimuli-responsive nanoplatforms at the lesions of interest [ 384 – 386 ]. Recently, Shuai et al [ 387 ] reported a GSH-responsive MOF to effectively load IDO inhibitor, and NO donor s-nitrosothiol groups for improving antitumor immunotherapy.…”

Section: Stimuli-responsive Targeting Strategiesmentioning

confidence: 99%

Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

et al. 2022

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Poor targeting of therapeutics leading to severe adverse effects on normal tissues is considered one of the obstacles in cancer therapy. To help overcome this, nanoscale drug delivery systems have provided an alternative avenue for improving the therapeutic potential of various agents and bioactive molecules through the enhanced permeability and retention (EPR) effect. Nanosystems with cancer-targeted ligands can achieve effective delivery to the tumor cells utilizing cell surface-specific receptors, the tumor vasculature and antigens with high accuracy and affinity. Additionally, stimuli-responsive nanoplatforms have also been considered as a promising and effective targeting strategy against tumors, as these nanoplatforms maintain their stealth feature under normal conditions, but upon homing in on cancerous lesions or their microenvironment, are responsive and release their cargoes. In this review, we comprehensively summarize the field of active targeting drug delivery systems and a number of stimuli-responsive release studies in the context of emerging nanoplatform development, and also discuss how this knowledge can contribute to further improvements in clinical practice.

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“…207 In recent years, there have been numerous reports of porphyrin MOF-targeted delivery of DOX for synergistic therapy. [208][209][210] In order to prevent drug leakage during targeted chemotherapy, mitigate the side effects of the treatment and improve the drug loading rate, Zhao and coworkers designed a ZnO-gated porphyrinic MOF (porMOF)-targeted PDT/chemotherapy system. 211 As shown in Fig.…”

Section: Targeted Applications Of Chemotherapymentioning

confidence: 99%

Research development of porphyrin-based metal–organic frameworks: targeting modalities and cancer therapeutic applications

Xiang¹,

Zhao²,

Sun³

et al. 2023

J. Mater. Chem. B

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Biomimetic smart nanoplatform for dual imaging-guided synergistic cancer therapy

Abstract: Developing an integrated multimodal diagnosis and therapeutics nanoplatform is of great importance to enhance the cancer therapy outcome. Herein, we report a highly efficient and biocompatible nanoplatform based on the...

Cited by 30 publications

References 65 publications

H2O2/pH Dual-Responsive Biomimetic Nanoenzyme Drugs Delivery System for Enhanced Tumor Photodynamic Therapy

H2O2/pH Dual-Responsive Biomimetic Nanoenzyme Drugs Delivery System for Enhanced Tumor Photodynamic Therapy

Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

Research development of porphyrin-based metal–organic frameworks: targeting modalities and cancer therapeutic applications

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