Biomimetic synthesis of spherical nano-hydroxyapatite in the presence of polyethylene glycol

Comparison of polyethylene glycol effect on hydroxyapatite morphology produced into different methods: sol–gel and precipitation

“…Indeed, PEG molecule has the ability to chelate Ca 2? [20]; therefore, PEG-OH can attract Ca 2? released from the Ca(NO 3 ) 2 Á4H 2 O to form the bond of PEG-O-Ca 2?…”

Template-directed hydrothermal synthesis of dandelion-like hydroxyapatite in the presence of cetyltrimethylammonium bromide and polyethylene glycol

“…Template-directed synthesis, an important synthetic strategy, is widely applied to control inorganic crystal morphology by adding organic ligands, additives, or templates [12][13][14]. A significant number of studies have focused on the synthesis of needle-like and rod-like HAp using cationic surfactant cetyltrimethylammonium bromide, which serves as a versatile soft template in HAp crystallization system [3,11,[15][16][17][18] biomimetic synthesis of spherical nanometer HAp in the presence of polyethylene glycol 6000 [7]. However, surfactants CTAB and PEG have seldom been used simultaneously.…”

“…Characteristics of HAp such as osteo-conductivity, bioactivity, biocompatibility, solubility, sinterability, castability, fracture toughness, and adsorption can be tailored over wide ranges by controlling its crystal morphology [5][6][7]. Therefore, it is of great importance to develop HAp synthesis methods having focused on the precise control of the crystal morphology.…”

The effect of high-energy ball milling parameters on the preparation and characterization of fluorapatite nanocrystalline powder

“…Synthetic hydroxyapatite (HA) is the most unique calcium phosphate that has been intensely studied over the recent years in the form of powder [1][2][3], coating [4,5] or composite [6,7] for different clinical applications involving repair of bone defects, bone augmentation, as well as coating for metallic implants; these medical applications have been developed for HA bioceramic due to its structural and compositional similarity to the mineralized matrix of natural bone [8]. However, high dissolution rate in biological environment, poor corrosion resistance in an acid environment and thermal decomposition as a result of poor chemical stability in high temperatures, have restricted the applications of HA [9].…”