Biomimetic triumvirate nanogel complexes via peptide-polysaccharide-polyphenol self-assembly

Tai, Min-Rui; Ji, Hongwu; Chen, Jianping; Liu, Xiaofei; Song, Bingbing; Zhong, Saiyi; Rifai, Aaqil; Nisbet, David R.; Barrow, Colin J.; Williams, Richard J.; Li, Rui

doi:10.1016/j.ijbiomac.2023.126232

Cited by 5 publications

(1 citation statement)

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“…Hesperidin was delivered using this coassembled biocompatible tissue-specific hydrogel, which was made of fucoidan laced within a self-assembling peptide backbone. The coassembly of the SAP with fucoidan was reported to improve the mechanical properties (from 9.54 Pa of Fmoc-FRGDF hydrogel to 7735 Pa of coassembled hydrogel at 6 mg/mL fucoidan concentration), form thicker nanofibril bundles at 4 and 6 mg/mL fucoidan concentration, improve the EE of hesperidin from 72.86% of Fmoc-FRGDF hydrogel to over 90% of the coassembled hydrogels, and demonstrate the efficiently controlled release of hesperidin in vitro [22]. However, the physical cross-linking sites in nanogels are unstable because they rely on weak interactions between polymer chains, such as hydrophobic or electrostatic interactions or hydrogen bonds.…”

Section: Synthesis Aspects Of Stimuli-responsive Nanogelsmentioning

confidence: 99%

Single-, Dual-, and Multi-Stimuli-Responsive Nanogels for Biomedical Applications

Kumar,

Singh,

Sharma

et al. 2024

Gels

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In recent years, stimuli-responsive nanogels that can undergo suitable transitions under endogenous (e.g., pH, enzymes and reduction) or exogenous stimuli (e.g., temperature, light, and magnetic fields) for on-demand drug delivery, have received significant interest in biomedical fields, including drug delivery, tissue engineering, wound healing, and gene therapy due to their unique environment-sensitive properties. Furthermore, these nanogels have become very popular due to some of their special properties such as good hydrophilicity, high drug loading efficiency, flexibility, and excellent biocompatibility and biodegradability. In this article, the authors discuss current developments in the synthesis, properties, and biomedical applications of stimulus-responsive nanogels. In addition, the opportunities and challenges of nanogels for biomedical applications are also briefly predicted.

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Section: Synthesis Aspects Of Stimuli-responsive Nanogelsmentioning

confidence: 99%