Biomimetics of Bone Implants: The Regenerative Road

Brett, Elizabeth A.; Flacco, John; Blackshear, Charles P.; Longaker, Michael T.; Wan, Derrick C.

doi:10.1089/biores.2016.0044

Cited by 34 publications

(24 citation statements)

References 63 publications

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“…Commercially available bone filler materials work through a simple scaffolding effect, providing osteoconduction. The new approach involving the biomolecular modification of biomaterials aims at enhancing the host tissue response through biologically active molecules delivered from the device or linked to the device surface [35][36][37][38]. In this broad scenario, the use of polyphenols from different source is widely investigated [32,[39][40][41][42][43][44][45].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Bone Regeneration Efficacy in a Rabbit Model of Femoral Condyles Defect by Polyphenols-Containing Bone Filler

Iviglia¹,

Cassinelli²,

Peris³

et al. 2020

J Dent Maxillofacial Res

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work we describe the in vivo outcomes of a calcium phosphate bone filler containing polyphenols from red grape pomace, implanted for 56 days in the medial condyle of the femur bone of rabbits, showing that the presence of polyphenols enhances bone regeneration properties of the biomaterial. Materials All chemicals were analytical-reagent grade and were purchased from Sigma-Aldrich. Red grape pomace was purchased from a local winery producer (Croatina grape from ALEMAT, Penango, AT, Italy). Ultra-pure (MilliQ) water was used for the preparation of aqueous solutions. Commercially available bone filler Ostim ® has been purchased on the market. NBR_White HA was used for enhancing the mechanical strength of scaffold, whereas β-TCP for its degradability; they were mixed in a percentage of 50 wt.%, respectively, to reach an optimum compromise between the two properties. The ceramic scaffolds were prepared by mixing HA and β-TCP powders (47 wt.%) with a binding agent (poly (vinyl alcohol), 3 wt.%), and ultrapure water (50 wt.%) to obtain a ceramic slurry. Dolapix CE 64 was added as a dispersing agent (1 wt.% of the solid load). The polyurethane (PU) sponge impregnation method was used to obtain a macroporous ceramic scaffold [24,25]. A commercial PU sponge slab (45 ppi) of 200 x 200 x 10 mm 3 was soaked into the

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Section: Discussionmentioning

confidence: 99%

Evaluation of Bone Regeneration Efficacy in a Rabbit Model of Femoral Condyles Defect by Polyphenols-Containing Bone Filler

Iviglia¹,

Cassinelli²,

Peris³

et al. 2020

J Dent Maxillofacial Res

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“…In a clinical setting, dental implants stimulate new bone formation through a physical effect, namely through a controlled surface roughness (24). The emerging field of biomolecular modifications of bone implants and dental biomaterials aims at enhancing the host tissue response through biologically active molecules delivered from the device or linked to the device surface (25)(26)(27)(28)(29). The biomolecular modification of dental devices and materials through polyphenols from different sources is being investigated (30)(31)(32)(33)(34)(35)(36)(37)(38).…”

Section: Introductionmentioning

confidence: 99%

Polyphenols from grape pomace induce osteogenic differentiation in mesenchymal stem cells

Torre¹,

Iviglia²,

Cassinelli³

et al. 2020

Int J Mol Med

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Polyphenols are increasingly investigated for the treatment of periodontitis and research on their use in dental biomaterials is currently being conducted. Grape pomace extracts are a rich source of polyphenols. In the present study, the polyphenols of two different types of grape pomace were characterized and identified by high-performance liquid chromatography-diode array detector, and the effect of polyphenol-rich grape pomace extracts on mesenchymal stem cell (MSc) osteogenic differentiation was investigated. Solid-liquid extraction was used to recover polyphenols from red and white grape pomace. The two extracts have been characterized through the phenolic content and antioxidant power. Human MScs (hMScs) from the bone marrow were cultured both with and without given amounts (10 or 20 µg/ml) of the obtained pomace extracts. Their effects on cell differentiation were evaluated by reverse transcription-quantitative polymerase chain reaction, compared with relevant controls. Results showed that both pomace extracts, albeit different in phenolic composition and concentration, induced multiple effects on hMSc gene expression, such as a decreased receptor activator of nuclear factor κ-Β ligand/osteoprotegerin ratio and an enhanced expression of genes involved in osteoblast differentiation, thus suggesting a shift of hMScs towards osteoblast differentiation. The obtained results provided data in favor of the exploitation of polyphenol properties from grape pomace extracts as complementary active molecules for dental materials and devices for bone regeneration in periodontal defects.

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“…Parallel to the growth and widespread acceptance of dental implantology, rising knowledge framed relevant interfacial biological events within a broader picture [15,16,17,18]. Cellular mechanisms leading to new bone formation and soft tissue healing, as well as inflammatory response leading to loss of supporting soft and hard tissue, are mediated by biological molecules and relevant signaling.…”

Section: Introductionmentioning

confidence: 99%

Covalently-Linked Hyaluronan versus Acid Etched Titanium Dental Implants: A Crossover RCT in Humans

Lupi

Baena

Cassinelli³

et al. 2019

IJMS

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Biochemical modification of titanium surfaces (BMTiS) entails immobilization of biomolecules to implant surfaces in order to induce specific host responses. This crossover randomized clinical trial assesses clinical success and marginal bone resorption of dental implants bearing a surface molecular layer of covalently-linked hyaluronan in comparison with control implants up to 36 months after loading. Patients requiring bilateral implant rehabilitation received hyaluronan covered implants in one side of the mouth and traditional implants in the other side. Two months after the first surgery, a second surgery was undergone to uncover the screw and to place a healing abutment. After two weeks, the operator proceeded with prosthetic procedures. Implants were evaluated by periapical radiographs and the crestal bone level was recorded at mesial and distal sites—at baseline and up to 36 months. One hundred and six implants were positioned, 52 HY-coated, and 48 controls were followed up. No differences were observed in terms of insertion and stability, wound healing, implant success, and crestal bone resorption at any time considered. All interventions had an optimal healing, and no adverse events were recorded. This trial shows, for the first time, a successful use in humans of biochemical-modified implants in routine clinical practice and in healthy patients and tissues with satisfactory outcomes.

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Biomimetics of Bone Implants: The Regenerative Road

Cited by 34 publications

References 63 publications

Evaluation of Bone Regeneration Efficacy in a Rabbit Model of Femoral Condyles Defect by Polyphenols-Containing Bone Filler

Evaluation of Bone Regeneration Efficacy in a Rabbit Model of Femoral Condyles Defect by Polyphenols-Containing Bone Filler

Polyphenols from grape pomace induce osteogenic differentiation in mesenchymal stem cells

Covalently-Linked Hyaluronan versus Acid Etched Titanium Dental Implants: A Crossover RCT in Humans

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