Biomimetics provides lessons from nature for contemporary ways to improve human health

Stenvinkel, Peter; Avesani, Carla María; Gordon, Line; Schalling, Martin; Shiels, Paul G.

doi:10.1017/cts.2021.790

Cited by 5 publications

(2 citation statements)

References 178 publications

(205 reference statements)

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“…One of the reasons might be that laboratory animal strains used in medical research are selectively bred to minimise individual variation as much as possible (Sikes & Gannon 2011 ). Yet variation is an essential part of nature and solutions derived from nature might provide useful tools to mitigate the effects of a changing climate on planetary and human health (Stenvinkel et al 2021 ).…”

Section: Introductionmentioning

confidence: 99%

The cost of research: Lasting effects of capture, surgery and muscle biopsy on brown bear (Ursus arctos) movement and physiology

Thiel,

Hertel,

Giroud

et al. 2023

Anim. welf.

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Animal models are a key component of translational medicine, helping transfer scientific findings into practical applications for human health. A fundamental principle of research ethics involves weighing the benefits of the research to society against the burden imposed on the animals used for scientific purposes. The utilisation of wild animals for research requires evaluation of the effects of capture and invasive sampling. Determining the severity and duration of these interventions on the animal’s physiology and behaviour allows for refining study methodology and for excluding or accounting for biased data. In this study, 39 Scandinavian brown bears (Ursus arctos) captured either while hibernating in winter or via helicopter in summer and that underwent surgery as part of a human health project had their movement, body temperature and timing of onset of hibernation compared with those of 14 control bears that had not been captured during the same period. Bears captured in winter and summer showed decreased movement from den exit until late summer, compared to those in the control group. Bears captured in summer showed reduced movement and body temperature for at least, respectively, 14 and 3 days, with an 11% decrease in hourly distance, compared to pre-capture levels, but did not differ in the timing of hibernation onset. We reveal that brown bear behaviour and physiology can be altered in response to capture and surgery for days to months, post-capture. This has broad implications for the conclusions of wildlife studies that rely upon invasive sampling.

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Section: Introductionmentioning

confidence: 99%

The cost of research: Lasting effects of capture, surgery and muscle biopsy on brown bear (Ursus arctos) movement and physiology

Thiel,

Hertel,

Giroud

et al. 2023

Anim. welf.

View full text Add to dashboard Cite

show abstract

“…The Clinical and Translational Science community is also responding. More than 600 reviews on health and climate change have been published in the last 3 years, including >90 systematic reviews (summarized by the British Medical Journal [3]), a superb analysis from The Lancet [4], and a recent JCTS review by Stenvinkel et al [5] highlighting that loss of biodiversity may irreversibly rob us of valuable models and therapeutics from the animal and plant kingdoms.…”

mentioning

confidence: 99%