Biomineralization-inspired synthesis of autologous cancer vaccines for personalized metallo-immunotherapy

Li, Quguang; Yan, Yifan; Wang, Chunjie; Dong, Ziliang; Hao, Yu; Chen, Minming; Liu, Zhuang; Feng, Liangzhu

doi:10.1016/j.isci.2024.110189

iScience

2024

DOI: 10.1016/j.isci.2024.110189

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Biomineralization-inspired synthesis of autologous cancer vaccines for personalized metallo-immunotherapy

Quguang Li,

Yifan Yan,

Chunjie Wang

et al.

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Cited by 1 publication

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Mechanotransduction-Piloted Whole-Cell Vaccines for Spatiotemporal Modulation of Postoperative Antitumor Immunity

Gu,

Xu,

et al. 2024

ACS Nano

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Whole tumor cell vaccines hold promise by presenting a broader spectrum of autologous-origin tumor antigens to combat postoperative recurrence and metastasis. However, challenges such as intractable adjuvant modification and obscure interactions with antigen-presenting cells in the postoperative microenvironment impede their translation into effective personalized immunotherapies. In this study, we propose cancer vaccines derived from manganese oxideimmobilized resected tumor cells, featuring whole tumor antigens and adjustable stiffness to modulate interactions with antigen-presenting cells in the postoperative microenvironment. These vaccines effectively stimulate dendritic cell phagocytosis and function through sequential stiffness-mediated mechanotransduction and interferon signaling. We evaluated their efficacy using an orthotopic triple-negative breast cancer mouse model and found that combining the vaccines with radiotherapy effectively inhibits postoperative tumor recurrence and metastasis. Our study underscores the potential of utilizing mechanotransduced adjuvants alongside directly inactivated whole-cell vaccines as a universal solution for preventing postoperative tumor recurrence.

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Mechanotransduction-Piloted Whole-Cell Vaccines for Spatiotemporal Modulation of Postoperative Antitumor Immunity

Gu,

Xu,

et al. 2024

ACS Nano

View full text Add to dashboard Cite

show abstract

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Biomineralization-inspired synthesis of autologous cancer vaccines for personalized metallo-immunotherapy

Cited by 1 publication

References 56 publications

Mechanotransduction-Piloted Whole-Cell Vaccines for Spatiotemporal Modulation of Postoperative Antitumor Immunity

Mechanotransduction-Piloted Whole-Cell Vaccines for Spatiotemporal Modulation of Postoperative Antitumor Immunity

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