Biomineralization of bone-like hydroxyapatite to upgrade the mechanical and osteoblastic performances of poly(lactic acid) scaffolds

Tang, Mengke; Xu, Ke; Han, Shang; Li, Xinyu; He, Xinjian; Ke, Lv; Xie, Minghui; Zhou, Zheng; Liu, Changhui; Du, Shengyang; Wang, Yanqing; Gao, Jiefeng; Xu, Huan

doi:10.1016/j.ijbiomac.2022.11.240

Cited by 24 publications

(12 citation statements)

References 67 publications

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“…As one of the most representative biodegradable candidates, 15,16 application prospects in the field of air filtration. 17,18 In considering the difficulty of effectively capturing PM 0.3 by the physical interception of fibers solely, the corona charging method is usually utilized to charge the fiber surface of PLA membranes in order to improve the filtration performance. 19,20 However, the low dielectric constant of PLA limits its charging capability, resulting in poor long-lasting electrostatic trapping capability.…”

Section: ■ Introductionmentioning

confidence: 99%

Biodegradable MOFilters for Effective Air Filtration and Sterilization by Coupling MOF Functionalization and Mechanical Polarization of Fibrous Poly(lactic acid)

Zhu

Tang

et al. 2023

ACS Appl. Mater. Interfaces

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High-performance air filtration materials are important for addressing the airborne pollutants. Herein, we propose an unprecedented access to biodegradable poly(lactic acid) (PLA)-based MOFilters with excellent filtering performance and antibacterial activity. The fabrication involved a stepwise in situ growth of zeolitic imidazolate framework-8 (ZIF-8) crystals at the surface of microfibrous PLA membranes, followed by mechanical polarization under high pressure and low temperature (5 MPa, 40 °C) to trigger the ordered alignment of dipoles in PLA chains and ZIF-8. The unique structural features allowed these PLA-based MOFilters to achieve an exceptional combination of excellent tensile properties, high dielectric constant (up to 2.4 F/m), and enhanced surface potential as high as 4 kV. Arising from the remarkable surface activity and electrostatic adsorption effect, a significant increase (from over 12% to nearly 20%) in PM0.3 filtration efficiency was observed for the PLA-based MOFilters compared to that of pure PLA counterparts, with weak relation to the airflow velocities (10–85 L/min). Moreover, the air resistance was controlled at a considerably low level for all the MOFilters, that is, below 183 Pa even at 85 L/min. It is worth noting that distinct antibacterial properties were achieved for the MOFilters, as illustrated by the inhibitive rates of 87 and 100% against Escherichia coli and Staphylococcus aureus, respectively. The proposed concept of PLA-based MOFilters offers unprecedented multifunction integration, which may fuel the development of biodegradable versatile filters with high capturing and antibacterial performances yet desirable manufacturing feasibility.

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Section: ■ Introductionmentioning

confidence: 99%

Biodegradable MOFilters for Effective Air Filtration and Sterilization by Coupling MOF Functionalization and Mechanical Polarization of Fibrous Poly(lactic acid)

Zhu

Tang

et al. 2023

ACS Appl. Mater. Interfaces

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“…In general, it is important to fabricate high-performance membrane filters by combining multiple filtration mechanisms, which could maintain filtration efficiency in a long-term situation with full degradability under broad environmental The hydroxyapatite bioelectret (HABE) was synthesized using the biomineralization method proposed in our recent effort. 27 For the sake of briefness, the detailed process is illustrated in the Supporting Information. Dichloromethane (DCM), N,N-dimethylformamide (DMF), deionized water, and other chemicals of analytical grade were obtained from Shanghai Aladdin Chemistry Co., Ltd.…”

Section: ■ Introductionmentioning

confidence: 99%

“…The hydroxyapatite bioelectret (HABE) was synthesized using the biomineralization method proposed in our recent effort. 27 For the sake of briefness, the detailed process is illustrated in the Supporting Information. Dichloromethane (DCM), N,N-dimethylformamide (DMF), deionized water, and other chemicals of analytical grade were obtained from Shanghai Aladdin Chemistry Co., Ltd.…”

Section: ■ Introductionmentioning

confidence: 99%

“…In general, it is important to fabricate high-performance membrane filters by combining multiple filtration mechanisms, which could maintain filtration efficiency in a long-term situation with full degradability under broad environmental requirements. The bone-like hydroxyapatite (HA) obtained from our previous study featured favorable biocompatibility . Herein, using HA as an eco-friendly electret with strong electrostatic effects by a reasonable structural design strategy, we attempted to fabricate electrospun PLA fibers with conjugated, specific protrusions in one step to construct bimodal fibers and biodegradable electret filter media based on highly electroactive HABE.…”

Section: Introductionmentioning

confidence: 99%

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Bioelectrets in Electrospun Bimodal Poly(lactic acid) Fibers: Realization of Multiple Mechanisms for Efficient and Long-Term Filtration of Fine PMs

Tang

Jiang

Wang

et al. 2023

ACS Appl. Mater. Interfaces

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Despite the great potential in fabrication of biodegradable and eco-friendly air filters by electrospinning poly(lactic acid) (PLA) membranes, the filtering performance is frequently dwarfed by inadequate physical sieving or electrostatic adsorption mechanisms to capture airborne particulate matters (PMs). Here, using the parallel spinning approach, the unique micro/nanoscale architecture was established by conjugation of neighboring PLA nanofibers, creating bimodal fibers in electrospun PLA membranes for the enhanced slip effect to significantly reduce the air resistance. Moreover, the bone-like nanocrystalline hydroxyapatite bioelectret (HABE) was exploited to enhance the dielectric and polarization properties of electrospun PLA, accompanied by the controlled generation of junctions induced by the microaggregation of HABE (10–30 wt %). The incorporated HABE was supposed to orderly align in the applied E-field and largely promote the charging capability and surface potential, gradually increasing to 7.2 kV from the lowest level of 2.5 kV for pure PLA. This was mainly attributed to HABE-induced orientation of PLA backbone chains and CO dipoles, as well as the interfacial charges trapped at the interphases of HABE–PLA and crystalline region–amorphous PLA. Given the multiple capturing mechanisms, the micro/nanostructured PLA/HABE membranes were characterized by excellent and sustainable filtering performance, e.g., the filtration efficiency of PM0.3 was promoted from 59.38% for pure PLA to 94.38% after addition of 30 wt % HABE at a moderate airflow capacity of 32 L/min and from 30.78 to 83.75% at the highest level of 85 L/min. It is of interest that the pressure drop was significantly decreased, mainly arising from the slip effect between the ultrafine nanofibers and conjugated microfibers. The proposed combination of the nanostructured electret and the multistructuring strategy offers the function integration of efficient filtration and low resistance that are highly useful to pursue fully biodegradable filters.

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“…Our cHLA/cAG was categorized as a naturally derived bioabsorbable polymer. Other holding materials include synthesized bioabsorbable polymer, namely, polylactic acid microfibers coupled with graphene/nHAp whiskers [ 37 ]. The prepared quaternary constructs also included BMP.…”

Section: Introductionmentioning

confidence: 99%

Self-Prepared Hyaluronic Acid/Alkaline Gelatin Composite with Nano-Hydroxyapatite and Bone Morphogenetic Protein for Cranial Bone Formation

Hachinohe

Taira

Hoshi

et al. 2023

IJMS

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New bone-forming substitute materials are highly useful in dental implantology. The purpose of this study was to prepare cross-linked hyaluronic acid (cHLA)/cross-linked alkaline gelatin (cAG)/nano-hydroxyapatite (nHAp)/bone morphogenic protein (BMP) constructs; and evaluate their bone-forming capabilities in rat cranial bone defects. The cHLA and cAG liquids processed with an epoxy cross-linker were blended with a 3:1 volume ratio, followed by freeze-drying. The dry composites were further infiltrated with water containing nHAp only (BMP (−)) or with water containing nHAp and BMP (BMP (+)). Prepared wet constructs (BMP (−) and BMP (+)) were implanted in rat cranial bone defects, while defects only were also made, and animals were fed for 8 weeks, followed by subsequent soft X-ray measurements and histological observations. The X-ray results showed that BMP (+) constructs disappeared, though caused inward extension of peripherical bone from defect edges with an increase in length of approximately 24%, larger than those of BMP (−) constructs and defect only with approximately 17% and 8% increments, respectively (p < 0.05). Histological observations of BMP (+) construct samples clearly indicated active bone extension consisting of an array of island-like bones. It was concluded that cHLA/cAG/nHAp/BMP could be used as novel bone-substitute materials.

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Biomineralization of bone-like hydroxyapatite to upgrade the mechanical and osteoblastic performances of poly(lactic acid) scaffolds

Cited by 24 publications

References 67 publications

Biodegradable MOFilters for Effective Air Filtration and Sterilization by Coupling MOF Functionalization and Mechanical Polarization of Fibrous Poly(lactic acid)

Biodegradable MOFilters for Effective Air Filtration and Sterilization by Coupling MOF Functionalization and Mechanical Polarization of Fibrous Poly(lactic acid)

Bioelectrets in Electrospun Bimodal Poly(lactic acid) Fibers: Realization of Multiple Mechanisms for Efficient and Long-Term Filtration of Fine PMs

Self-Prepared Hyaluronic Acid/Alkaline Gelatin Composite with Nano-Hydroxyapatite and Bone Morphogenetic Protein for Cranial Bone Formation

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