Biomineralization of dentin

Remineralization of dentin slices using casein phosphopeptide–amorphous calcium phosphate combined with sodium tripolyphosphate

“…Collagen fibrils are the main organic component of dentin, which provide a scaffold for mineral deposition during remineralization. However, the collagen fibril cannot control the mineral deposition and the remineralization process mainly depends on noncollagen proteins in dentin [6]. The natural process of dentin mineralization occurs via regulation of non-collagen protein in conjunction with deposition of calcium and phosphorus elements on dentin collagen fibrils, followed by formation of hydroxyapatite to complete the mineralization process [25].…”

“…The most robust strategy to reduce dentine hypersensitivity entails painless and non-invasive remineralization, leading to the formation of a remineralized layer on dentin. The remineralization approach mechanically occludes the exposed dentinal tubules mechanically, reduces the permeability of dentinal tubules and eliminates the symptoms of dentin hypersensitivity [6,7]. Dentin is a mineralized collagenous tissue and demineralized dentin does not significantly induce the deposition of calcium phosphate minerals in the remineralization solution.…”

The use of bioactive particles and biomimetic analogues for increasing the longevity of resin-dentin interfaces: A literature review

“…Biomimetic remineralization relies on backfilling the demineralized dentin collagen with liquid-like ACP nanoparticles (referred to as mineral precursors) stabilized by biomimetic analogs of non-collagenous proteins. These analogues are characterized by the presence of aspartic acid and glutamic acid-rich domains, as well as phosphoproteins that may act as nucleators or inhibitors, growth modifiers, anchoring molecules, or as scaffolds for mineral deposition 12,13,16) . More than ten different analogs have been tested for dentin remineralization 47) .…”

“…Remineralization of resin-dentin interfaces has been studied aiming to replace water from intrafibrillar gaps, as well as from water-rich, resin-sparse regions of the hybrid layer, with apatite crystallites. By doing so, it would be possible to increase the mechanical properties of the dentin-resin interphase and protect the exposed collagen from external challenges [8][9][10][11][12] . Dentin remineralization strategy is dependent on the remaining mineral content of the tissue 13) .…”

Otojen Di̇ş Kemi̇k Grefti̇ni̇n Bi̇yoloji̇k Özelli̇kleri̇ Ve Kli̇ni̇k Kullanimi

“…1,2,5,7,8,10 Alveoler kemik dokusunun inorganik, organik ve su içeriği sırasıyla % 65, % 25 ve % 10'dur ve benzer olarak, dentin dokusu, % 70-75 inorganik, % 20 organik ve % 10 sudan oluşmaktadır. [11][12][13][14] Kemik dokusunda olduğu gibi dentin dokusu da, mekanik ve biyolojik desteklik sağlar: 1) üst üste binen katmanlar halinde mine dokusunun altında kuvvet dağılımı sağlayarak çatlak veya kırık oluşumunu önler, 2) vaskülarizasyonu sağlayan pulpa dokusu için biyolojik koruma sağlar. 13 Kemik ve dentin gelişiminde hücresel aktivite benzerlik göstermektedir.…”