Biomineralization, strength and cytocompatibility improvement of bredigite scaffolds through doping/coating

Keihan, R.; Ghorbani, A.R.; Salahinejad, E.; Sharifi, Esmaeel; Tayebi, Lobat

doi:10.1016/j.ceramint.2020.05.178

Cited by 13 publications

(2 citation statements)

References 54 publications

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“…The porosities of various SiCa and composite scaffolds have been measured using the aforementioned methods: liquid displacement (distilled water), [ 33,49,50,59,67,68,70,71,74,88–120 ] liquid displacement (ethanol), [ 121–125 ] liquid displacement (hexane), [ 126–129 ] liquid displacement (kerosene), [ 130 ] mercury intrusion, [ 131–135 ] gravimetry [ 45,65,110,136–138 ] , μ‐CT, [ 114,116,139–145 ] 1, and SEM [ 75,84,85,143,146–150 ] according to the literature.…”

Section: Methods To Measure the Porosity Of Porous Scaffoldsmentioning

confidence: 99%

“…Applying a polymer coating on the ceramic scaffold can improve the compressive strength of the scaffold. [196] Hitherto, various polymers such as polycaprolactone fumarate (PCLF), [94,118] polycaprolactone (PCL), [84,118,120,121,141] poly(lactic-co-glycolic acid) (PLGA) [96,98,101] and silk [59,128,150] have been used as coating on SiCa scaffolds. Such polymeric coatings were found to decrease the pore size and increase the compressive strength.…”

Section: Effect Of Coatingmentioning

confidence: 99%

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How Does Scaffold Porosity Conduct Bone Tissue Regeneration?

et al. 2021

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Despite progresses in tissue healing, repairing large bone defects remains an unmet challenge. Tissue engineering (TE) using porous scaffolds offers great promise in providing solutions by which bone healing can be increased, and the need for further surgical intervention can be reduced. Nonetheless, the successful performance of a porous scaffold depends on key structural factors including porosity, pore size, geometry, and interconnectivity. Herein, recent advancements on this topic are reviewed and the effects of fabrication methods on making potential scaffolds for advanced bone regeneration are discussed.The upward trend of population aging, increased numbers of accidents, sport injuries, trauma, and bone tumor resection are increasing the demand for substitutes to regenerate and/or repair damaged skeletal and dental bones. [1] Bone tissue poses a simple yet highly organized ultracomposition in which each portion plays a pivotal role in moderating the elasticity and strength of the bone. [2] The intrinsically dynamic bone tissue structure allows the restoration of damaged parts via the self-healing process. [3] This remodeling process is dependent on the dynamic equilibrium between the bone-forming (osteoblast) and bone-resorbing cells (osteoclast) during mechanical stimulation. [4] Nevertheless, this healing process is not sufficient for repairing massive and critical bone defects; thus, there is a need for drastic healing accelerators and substitutive or supportive therapeutics. [5] Specially, the regenerating of large bone defects is a serious and challenging clinical issue. To address the issue, different types of bone graft substitutes such as autografts, allografts, and xenografts are used. [6] These grafts, however, come with certain drawbacks, including donor site morbidity and limited supply. Moreover, aged persons cannot provide rich bone tissue for their own tissue replacement due to osteoporosis. [7] To address the limitations associated with natural bone-derived substitutes, biomaterials have been developed during recent decades. [8] Engineering biomaterials made it possible to simulate the bone microenvironment and construct programmable scaffolds for purposeful therapeutic procedures. Bioactive ceramic materials are favorable for bone tissue engineering (BTE) due to their resemblance to the mineral phase of bone, and direct bonding with host bone tissue without the formation of fibrous tissue. In addition, the variety in the chemical composition of bioceramics, particularly silicate-based ceramics (SiCa), can contribute to adjustments in mechanical properties, bioactivity, and biodegradability.A fundamental constituent of engineering tissue is the scaffold, which acts as the structural template providing a suitable substrate for cell proliferation, differentiation, and attachment resulting in new tissue formation. In tissue engineering (TE), the scaffold serves as the structural guide and the substrate for cell anchorage. The scaffold also contributes to the remodeling of the extracellular mat...

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Section: Methods To Measure the Porosity Of Porous Scaffoldsmentioning

confidence: 99%

Section: Effect Of Coatingmentioning

confidence: 99%

How Does Scaffold Porosity Conduct Bone Tissue Regeneration?

et al. 2021

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Bredigite Bioceramic: A Promising Candidate for Bone Tissue Engineering

Khodaei,

Nadi

2024

Silicon

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Forsterite-hydroxyapatite composite scaffolds with photothermal antibacterial activity for bone repair

et al. 2021

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Bone engineering scaffolds with antibacterial activity satisfy the repair of bacterial infected bone defects, which is an expected issue in clinical. In this work, 3D-printed polymer-derived forsterite scaffolds were proposed to be deposited with hydroxyapatite (HA) coating via a hydrothermal treatment, achieving the functions of photothermal-induced antibacterial ability and bioactivity. The results showed that polymer-derived forsterite scaffolds possessed the photothermal antibacterial ability to inhibit Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) in vitro, owing to the photothermal effect of free carbon embedded in the scaffolds. The morphology of HA coating on forsterite scaffolds could be controlled through changing the hydrothermal temperature and the pH value of the reaction solution during hydrothermal treatment. Furthermore, HA coating did not influence the mechanical strength and photothermal effect of the scaffolds, but facilitated the proliferation and osteogenic differentiation of rat bone mesenchymal stem cells (rBMSCs) on scaffolds. Hence, the HA-deposited forsterite scaffolds would be greatly promising for repairing bacterial infected bone defects.

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Biomineralization, strength and cytocompatibility improvement of bredigite scaffolds through doping/coating

Cited by 13 publications

References 54 publications

How Does Scaffold Porosity Conduct Bone Tissue Regeneration?

How Does Scaffold Porosity Conduct Bone Tissue Regeneration?

Bredigite Bioceramic: A Promising Candidate for Bone Tissue Engineering

Forsterite-hydroxyapatite composite scaffolds with photothermal antibacterial activity for bone repair

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