Biomineralized Bimetallic Oxide Nanotheranostics for Multimodal Imaging-Guided Combination Therapy

Wu, Jianrong; Williams, Gareth R.; Niu, Shiwei; Yang, Yanbo; Yu, Li; Zhang, Xintong; Zhu, Li‐Min

doi:10.7150/thno.40715

Cited by 60 publications

(30 citation statements)

References 49 publications

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“…In prostate cancer, PLIN3 upregulation has been associated with poor prognosis in patients [ 88 ]. Moreover, elevated PLIN3 expression has recently been related to poor prognosis of lung adenocarcinoma, whereas ablation of PLIN3 inhibited the invasion ability of lung adenocarcinoma cells [ 89 ].…”

Section: Perilipins In Cancer: the Unrevealed Role Of Plin5mentioning

confidence: 99%

Understanding the Role of Perilipin 5 in Non-Alcoholic Fatty Liver Disease and Its Role in Hepatocellular Carcinoma: A Review of Novel Insights

Sanchez

Krizanac

Weiskirchen

et al. 2021

IJMS

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Consumption of high-calorie foods, such as diets rich in fats, is an important factor leading to the development of steatohepatitis. Several studies have suggested how lipid accumulation creates a lipotoxic microenvironment for cells, leading cells to deregulate their transcriptional and translational activity. This deregulation induces the development of liver diseases such as non-alcoholic fatty liver disease (NAFLD) and subsequently also the appearance of hepatocellular carcinoma (HCC) which is one of the deadliest types of cancers worldwide. Understanding its pathology and studying new biomarkers with better specificity in predicting disease prognosis can help in the personalized treatment of the disease. In this setting, understanding the link between NAFLD and HCC progression, the differentiation of each stage in between as well as the mechanisms underlying this process, are vital for development of new treatments and in exploring new therapeutic targets. Perilipins are a family of five closely related proteins expressed on the surface of lipid droplets (LD) in several tissues acting in several pathways involved in lipid metabolism. Recent studies have shown that Plin5 depletion acts protectively in the pathogenesis of liver injury underpinning the importance of pathways associated with PLIN5. PLIN5 expression is involved in pro-inflammatory cytokine regulation and mitochondrial damage, as well as endoplasmic reticulum (ER) stress, making it critical target of the NAFLD-HCC studies. The aim of this review is to dissect the recent findings and functions of PLIN5 in lipid metabolism, metabolic disorders, and NAFLD as well as the progression of NAFLD to HCC.

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Section: Perilipins In Cancer: the Unrevealed Role Of Plin5mentioning

confidence: 99%

Understanding the Role of Perilipin 5 in Non-Alcoholic Fatty Liver Disease and Its Role in Hepatocellular Carcinoma: A Review of Novel Insights

Sanchez

Krizanac

Weiskirchen

et al. 2021

IJMS

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“…MnO 2 in the composite can produce O 2 by decomposing H 2 O 2 overcoming the hypoxia, thus enhancing the efficacy of PDT, and the released Mn2 + ions can act as contrast agents for magnetic resonance imaging (MRI). In vitro and in vivo evaluation showed that this multifunctional nanotheranostic is an "all in one system" offering highly effective synergistic therapy for photothermal therapy (PTT), PDT, and excellent CT/MRI/PA trimodal imaging (Figure 3) [62].…”

Section: Natural Polymers In Nanotheranostic Agent Design 221 Albuminmentioning

confidence: 99%

Polymer-Drug Conjugates as Nanotheranostic Agents

Manandhar

Sjöholm

Bobacka

et al. 2021

JNT

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Since the last decade, the polymer-drug conjugate (PDC) approach has emerged as one of the most promising drug-delivery technologies owing to several benefits like circumventing premature drug release, offering controlled and targeted drug delivery, improving the stability, safety, and kinetics of conjugated drugs, and so forth. In recent years, PDC technology has advanced with the objective to further enhance the treatment outcomes by integrating nanotechnology and multifunctional characteristics into these systems. One such development is the ability of PDCs to act as theranostic agents, permitting simultaneous diagnosis and treatment options. Theranostic nanocarriers offer the opportunity to track the distribution of PDCs within the body and help to localize the diseased site. This characteristic is of particular interest, especially among those therapeutic approaches where external stimuli are supposed to be applied for abrupt drug release at the target site for localized delivery to avoid systemic side effects (e.g., Visudyne®). Thus, with the help of this review article, we are presenting the most recent updates in the domain of PDCs as nanotheranostic agents. Different methodologies utilized to design PDCs along with imaging characteristics and their applicability in a wide range of diseases, have been summarized in this article.

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“…The biomineralized organic–inorganic composite nanoprobes have attracted more and more attention because of their strong light absorption, easy regulation, good biocompatibility, high photothermal stability, and versatility. [ 183 ]…”

Section: Application Of Nanoparticle Drug Delivery Systems Based On Bmentioning

confidence: 99%

Biomineralization: An Opportunity and Challenge of Nanoparticle Drug Delivery Systems for Cancer Therapy

Wang

Liu

Zheng

et al. 2020

Adv Healthcare Materials

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Biomineralization is a common process in organisms to produce hard biomaterials by combining inorganic ions with biomacromolecules. Multifunctional nanoplatforms are developed based on the mechanism of biomineralization in many biomedical applications. In the past few years, biomineralization-based nanoparticle drug delivery systems for the cancer treatment have gained a lot of research attention due to the advantages including simple preparation, good biocompatibility, degradability, easy modification, versatility, and targeting. In this review, the research trends of biomineralization-based nanoparticle drug delivery systems and their applications in cancer therapy are summarized. This work aims to promote future researches on cancer therapy based on biomineralization. Rational design of nanoparticle drug delivery systems can overcome the bottleneck in the clinical transformation of nanomaterials. At the same time, biomineralization has also provided new research ideas for cancer treatment, i.e., targeted therapy, which has significantly better performance.

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Biomineralized Bimetallic Oxide Nanotheranostics for Multimodal Imaging-Guided Combination Therapy

Cited by 60 publications

References 49 publications

Understanding the Role of Perilipin 5 in Non-Alcoholic Fatty Liver Disease and Its Role in Hepatocellular Carcinoma: A Review of Novel Insights

Understanding the Role of Perilipin 5 in Non-Alcoholic Fatty Liver Disease and Its Role in Hepatocellular Carcinoma: A Review of Novel Insights

Polymer-Drug Conjugates as Nanotheranostic Agents

Biomineralization: An Opportunity and Challenge of Nanoparticle Drug Delivery Systems for Cancer Therapy

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