Biomineralized Enzyme-Like Cobalt Sulfide Nanodots for Synergetic Phototherapy with Tumor Multimodal Imaging Navigation

Abstract

Fabrication of nanotheranostic agents attracted a growing interest in accurate diagnosis and therapy of cancer by the sustainable biomineralization strategy. Herein, it is reported that biomineralized cobalt sulfide nanodots (Co 9 S 8 NDs) with intrinsic peroxidase-like activity are potentially useful for synergetic phototherapy with tumor multimodal imaging navigation. The multifunctional Co 9 S 8 NDs are first synthesized in aqueous phase via a simple biomineralization route. Detailed characterization reveals that the constructed peroxidase-like Co 9 S 8 NDs not only possess strong paramagnetism with near-infrared absorption but also generate reactive oxygen species via photocatalytic reaction. As a result, the Co 9 S 8 NDs reveal excellent performance for magnetic resonance and photoacoustic imaging of tumors, and outstanding tumor ablation efficiency owing to the near-infrared responsive photodynamic and photothermal effect. To our knowledge, ultrasmall Co 9 S 8 NDs via aqueous phase synthesis have not been reported for multimodal theranostic applications so far.

Engineering of bioactive metal sulfide nanomaterials for cancer therapy

“…In general, breeding BSA with metal ions drove the formation of metal-BSA complexes. Subsequently, the nucleation of MeSNs was sped up by bringing Na 2 S or thioacetamide into the mixture [ 65 , 67 ]. In contrast to the solvothermal approach, the biomineralization approach is conducted at 37℃, which assures the immutability of BSA.…”

Photo‐responsive nanozymes: Mechanism, activity regulation, and biomedical applications

“…FCo 9 S 8 nanodots (NDs) can produce •OH by POD‐like activity, and they show stronger 3,3′,5,5′‐tetramethylbenzidine (TMB) oxidation performance in the presence of both near‐infrared (NIR) light and H 2 O 2 . Under NIR light excitation, Co 9 S 8 NDs can promote both gathering and separation of charge carriers, decrease their recombination rate, and thus improve the ROS generation ability 46 . Similarly, the temperature increase is not the main factor to improve the enzyme‐like activities of a kind of yolk‐shell structure containing an Au core and a hollow carbon shell (Au@HCNs) under NIR light irradiation.…”

“…The effect of “The whole is greater than the sum of its parts” generated by both photoactivity and the enzyme‐like activity of the nanozymes is called photo‐synergistic action, which is not necessarily a strong mutual influence between the two parts. Nanozymes with photothermal effect can be applied to photothermal therapy, and the •OH produced by their POD‐like activity can induced cellular poptosis, so that a high‐efficiency antitumor effect can be achieved 46,47,51 . Take Au@Pt Nanozyme as an example, it combines excellent photothermal performance and POD‐like activity that can simultaneously quantify protein concentration with photothermal, colorimetric, and ratiometric fluorescence immunoassay to achieve more accurate detection 52 …”

Functional Mesoporous Silica Nanocomposites: Biomedical Applications and Biosafety

“…This could be employed to design multiple apoptosis-inducing systems with a single photon excitation. Interesting examples have been described with Au [ 152 ], CuS and CoS [ 153 ], although none have been described in combination with MS. For an outstanding and recent review on the modification of MSNs with different PS for PDE, please check references [ 154 , 155 ] ( Figure 8 ).…”