Biomineralized synthesis of palladium nanoflowers for photothermal treatment of cancer and wound healing

He, Jinfeng; Wang, Jing; Gao, Shiyou; Cui, Yanshuai; Ji, Xianbing; Zhang, Xiaoyu; Wang, Longgang

doi:10.1016/j.ijpharm.2022.121489

Cited by 37 publications

(26 citation statements)

References 57 publications

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“…The photothermal conversion efficiency of Dap-AgNPs was calculated by irradiating with an 808-nanometer laser with a power of 1.75 W/cm 2 until the temperature no longer changed, after which the laser was turned off and the solution was allowed to cool naturally. The photothermal conversion efficiency ( η ) of Dap-AgNPs was calculated from Formula (1) [ 25 ], as follows:

where h refers to thermal conductivity; S refers to the surface area of the container; T max refers to the maximum temperature; T sur refers to the ambient temperature; Q Dis refers to the light energy absorbed by the container; I refers to the light-source power; A λ 808 refers to absorption of near-infrared light at 808 nm.…”

Section: Methodsmentioning

confidence: 99%

“…HeLa cells, as human cervical cancer cells, and HT-29 cells, as human colon cancer cells, were used as typical tumor cells in the MTT assay [ 25 ]. HeLa cells and HT-29 cells were seeded separately in 96-well plates, and 200 μL of culture medium was added and incubated at 37 °C for 24 h. The existing medium was then replaced with 200 μL of the sample solution in DMEM medium.…”

Section: Methodsmentioning

confidence: 99%

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Daptomycin-Biomineralized Silver Nanoparticles for Enhanced Photothermal Therapy with Anti-Tumor Effect

et al. 2022

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Silver nanoparticles as photothermal agents have the problems of low stability and low photothermal conversion efficiency. Amphiphilic daptomycin can improve the stability of silver nanoparticles, thereby improving their photothermal conversion efficiency. Herein, daptomycin-biomineralized silver nanoparticles (Dap-AgNPs) were prepared by reducing silver nitrate with sodium borohydride in the presence of daptomycin as a stabilizer and biomineralizer. The Dap-AgNPs had good solution stability and peroxidase-like activity. Furthermore, the photothermal conversion efficiency of the Dap-AgNPs was as high as 36.8%. The Dap-AgNPs displayed good photothermal stability under irradiation. More importantly, the Dap-AgNPs showed good cell compatibility with HeLa cells and HT-29 cells without irradiation by 808-nanometer near-infrared light at a concentration of 0.5 mM, and the cell viability was greater than 85.0%. However, the Dap-AgNPs displayed significant anti-tumor ability with irradiation by 808-nanometer near-infrared light, which was due to the increasing temperature of the culture medium caused by the Dap-AgNPs. In conclusion, Dap-AgNPs have potential applications as photothermal agents in the treatment of tumors.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Daptomycin-Biomineralized Silver Nanoparticles for Enhanced Photothermal Therapy with Anti-Tumor Effect

et al. 2022

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“…Recent studies revealed that bio-synthesized palladium nanoparticles (Pd NPs) present antioxidant, anticancer, antimicrobial, antiproliferative, and photothermal activities while being biocompatible and less toxic than their chemically-synthesized counterparts [118]. Thus, they hold great promise in developing novel and improved cancer therapies, being already evaluated against several cancer cell lines (e.g., lung cancer [48], breast cancer [119], ovarian cancer [120], cervical cancer [121], and colorectal adenocarcinoma [121]).…”

Section: Other Metal-based Nanomaterialsmentioning

confidence: 99%

Recent Developments in Metallic Nanomaterials for Cancer Therapy, Diagnosing and Imaging Applications

et al. 2022

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Cancer continues to represent a global health concern, imposing an ongoing need to research for better treatment alternatives. In this context, nanomedicine seems to be the solution to existing problems, bringing unprecedented results in various biomedical applications, including cancer therapy, diagnosing, and imaging. As numerous studies have uncovered the advantageous properties of various nanoscale metals, this review aims to present metal-based nanoparticles that are most frequently employed for cancer applications. This paper follows the description of relevant nanoparticles made of metals, metal derivatives, hybrids, and alloys, further discussing in more detail their potential applications in cancer management, ranging from the delivery of chemotherapeutics, vaccines, and genes to ablative hyperthermia therapies and theranostic platforms.

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“…We believe that daptomycin may be an excellent therapeutic option in patients with MRSA-infected diabetic foot or diabetic ulcers with difficult wound healing. A new method consists of including daptomycin in micelles-stabilized palladium nanoflowers by exploiting the photothermal action to convert laser light (808nm) into thermal energy [43]. This method (Dap-PdNFs + laser group) was proven to be effective in vitro against S. Aureus, reducing its viability after 10 min of laser to 30.93% (vs. 79.76%, Dap + laser group, vs. 85.14% PdNPs + laser group).…”

Section: Diabetic Footmentioning

confidence: 99%

Role of Daptomycin in Cutaneous Wound Healing: A Narrative Review

et al. 2022

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Daptomycin is active against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and the on-label indications for its use include complicated skin and skin structure infections (cSSSI). We performed a narrative review of the literature with the aim to evaluate the role of daptomycin in the skin wound healing process, proposing our point of view on the possible association with other molecules that could improve the skin healing process. Daptomycin may improve wound healing in MRSA-infected burns, surgical wounds, and diabetic feet, but further studies in humans with histological examination are needed. In the future, the combination of daptomycin with other molecules with synergistic action, such as vitamin E and derivates, IB-367, RNA III-inhibiting peptide (RIP), and palladium nanoflowers, may help to improve wound healing and overcome forms of antibiotic resistance.

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Biomineralized synthesis of palladium nanoflowers for photothermal treatment of cancer and wound healing

Cited by 37 publications

References 57 publications

Daptomycin-Biomineralized Silver Nanoparticles for Enhanced Photothermal Therapy with Anti-Tumor Effect

Daptomycin-Biomineralized Silver Nanoparticles for Enhanced Photothermal Therapy with Anti-Tumor Effect

Recent Developments in Metallic Nanomaterials for Cancer Therapy, Diagnosing and Imaging Applications

Role of Daptomycin in Cutaneous Wound Healing: A Narrative Review

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