Biomolecular glass with amino acid and peptide nanoarchitectonics

Xing, Ronge; Yuan, Chengqian; Fan, Wei; Ren, Xiaokang; Yan, Xuehai

doi:10.1126/sciadv.add8105

Cited by 66 publications

(32 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A recent study investigated the biodegradability of a Cbz-FFG peptide-based glassy material. The results indicate that the peptide-based glassy beads are capable of degradation both in vivo and in vitro in the presence of proteinase K solution . The gastrointestinal digestion of food-protein-based amyloid fibrils has been studied in vitro and in vivo .…”

Section: Properties and Applicationsmentioning

confidence: 99%

From Fundamental Amyloid Protein Self-Assembly to Development of Bioplastics

Li,

Kambanis,

Sorenson

et al. 2023

Biomacromolecules

View full text Add to dashboard Cite

Proteins can self-assemble into a range of nanostructures as a result of molecular interactions. Amyloid nanofibrils, as one of them, were first discovered with regard to the relevance of neurodegenerative diseases but now have been exploited as building blocks to generate multiscale materials with designed functions for versatile applications. This review interconnects the mechanism of amyloid fibrillation, the current approaches to synthesizing amyloid protein-based materials, and the application in bioplastic development. We focus on the fundamental structures of self-assembled amyloid fibrils and how external factors can affect protein aggregation to optimize the process. Protein self-assembly is essentially the autonomous congregation of smaller protein units into larger, organized structures. Since the properties of the self-assembly can be manipulated by changing intrinsic factors and external conditions, protein self-assembly serves as an excellent building block for bioplastic development. Building on these principles, general processing methods and pathways from raw protein sources to mature state materials are proposed, providing a guide for the development of large-scale production. Additionally, this review discusses the diverse properties of protein-based amyloid nanofibrils and how they can be utilized as bioplastics. The economic feasibility of the protein bioplastics is also compared to conventional plastics in large-scale production scenarios, supporting their potential as sustainable bioplastics for future applications. P lastics are now found in every sector of our life, such as packaging, personal care products, electronics, and clothing, while the contamination caused by the accumulation of single-use plastic 1−5 and microplastics 6,7 has become a serious threat to the natural environment, wildlife, and humans. Current plastics can be classified based on their source and their biodegradability, as shown in Figure 1. 8 Some plastics are

show abstract

Section: Properties and Applicationsmentioning

confidence: 99%

From Fundamental Amyloid Protein Self-Assembly to Development of Bioplastics

Li,

Kambanis,

Sorenson

et al. 2023

Biomacromolecules

View full text Add to dashboard Cite

show abstract

“…In another work, they described the formation of amorphous biomolecular glasses with appreciable biodegradability, biorecyclability, and excellent optical characteristics from chemically modified amino acids and peptides using a classic heating-quenching procedure. This result clearly revealed that the absolute change in thermodynamic and kinetic parameters effectively controlled the self-assembly process with morphological transition Scheme shows the stepwise fabrication of TP , TPZn , and (TP) 2 Zn into different self-assembled structures with morphological individualities in 90% aqueous-THF medium of varying polarities. ,, …”

Section: Resultsmentioning

confidence: 81%

“…This result clearly revealed that the absolute change in thermodynamic and kinetic parameters effectively controlled the self-assembly process with morphological transition. 68 Scheme 2 shows the stepwise fabrication of TP, TPZn, and (TP) 2 Zn into different self-assembled structures with morphological individualities in 90% aqueous-THF medium of varying polarities. 19,54,69 The modes of the molecular aggregation of TP, TPZn, and (TP) 2 Zn in a highly polar 90% aqueous-THF medium were further confirmed from PXRD analysis of the dried mass of these compounds obtained from a 9:1 aqueous-THF medium.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Polarity-Induced Morphological Transformation with Tunable Optical Output of Terpyridine–Phenanthro[9,10-d]imidazole-Based Ligand and Its Zn(II) Complexes with I–V Characteristics

Rana,

Jennifer G,

Rao T

et al. 2023

ACS Omega

View full text Add to dashboard Cite

Self-assembled nanostructures obtained from various functional π-conjugated organic molecules have been able to draw substantial interest due to their inherent optical properties, which are imperative for developing optoelectronic devices, multiple-color-emitting devices with color-tunable displays, and optical sensors. These π-conjugated molecules have proven their potential employment in various organic electronic applications. Therefore, the stimuli-responsive fabrication of these π-conjugated systems into a well-ordered assembly is extremely crucial to tuning their inherent optical properties for improved performance in organic electronic applications. To this end, herein, we have designed and synthesized a functional π-conjugated molecule ( TP ) having phenanthro[9,10- d ]imidazole with terpyridine substitution at the 2 position and its corresponding metal complexes ( TPZn and (TP) 2 Zn ). By varying the polarity of the self-assembly medium, TP , TPZn , and (TP) 2 Zn are fabricated into well-ordered superstructures with morphological individualities. However, this medium polarity-induced self-assembly can tune the inherent optical properties of TP , TPZn , and (TP) 2 Zn and generate multiple fluorescence colors. Particularly, this property makes them useful for organic electronic applications, which require adjustable luminescence output. More importantly, in 10% aqueous-THF medium, TPZn exhibited H-type aggregation-induced white light emission and behaved as a single-component white light emitter. The experimentally obtained results of the solvent polarity-induced variation in optical properties as well as self-assembly patterns were further confirmed by theoretical investigation using density functional theory calculations. Furthermore, we investigated the I – V characteristics, both vertical and horizontal, using ITO and glass surfaces coated with TP , TPZn , and (TP) 2 Zn , respectively, and displayed maximum current density for the TPZn -coated surface with the order of measured current density TPZn > TP > (TP) 2 Zn . This observed order of current density measurements was also supported by a direct band gap calculation associated with the frontier molecular orbitals using the Tauc plot. Hence, solvent polarity-induced self-assembly behavior with adjustable luminescence output and superior I – V characteristics of TPZn make it a...

show abstract

“…Compared to silicate or metallic glass, BSGs exhibit lower annealing and glass transition temperatures; thus, their glassy nature can be easily studied. 34,43,44 The low-molecular-weight BSGs enable more choices for characterization. For example, solution-state 1 H NMR spectroscopy can be used to study the driving forces in BSGs.…”

Section: Discussionmentioning

confidence: 99%