Biomolecular Imaging at High Spatial and Temporal Resolution In Vitro and In Vivo

Sharp, Thomas H.

doi:10.1007/978-3-319-02159-1

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2015

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References 75 publications

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“…Several studies have demonstrated that Au [32] and Bi 2 S 3 [28] NPs are internalized by cells via endocytosis, and in some cases the former have been found 'clustered' around the membrane within the cytoplasm [18,33]. Therefore, the NPs are expected to be internalized and enclosed inside the cells enhancing the radiation effect.…”

Section: Discussionmentioning

confidence: 99%

Radiation Dose Enhancement Using Bi2S3 Nanoparticles in Cultured Mouse PC3 Prostate and B16 Melanoma Cells

Algethami¹

2015

NanoWorld J

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Gold nanoparticles (Au NPs) have been extensively investigated as contrast and dose enhancing agents. Bismuth sulfide (Bi 2 S 3 )-NPs have recently been investigated as contrast agents in radiology. In this study the dose enhancing effects of Bi 2 S 3 -NPs on radiated mouse PC3 prostate and B16 melanoma cells were examined. Equimolar concentrations of both Au and Bi 2 S 3 -NPs displayed equal dose enhancement with B16 cells, while the latter provided higher values with PC3 cells. At, equimolar concentrations there are less Bi atoms compared to Au in their respective NPs. Both NPs at comparable concentrations (0-1 mM) elicited similar cytotoxicity in PC3 mouse prostate cells. This study demonstrates that the less expensive Bi 2 S 3 NPs are a viable alternative to Au NPs as a dose enhancing agent in clinical applications.

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Section: Discussionmentioning

confidence: 99%

Radiation Dose Enhancement Using Bi2S3 Nanoparticles in Cultured Mouse PC3 Prostate and B16 Melanoma Cells

Algethami¹

2015

NanoWorld J

View full text Add to dashboard Cite

show abstract

Biomolecular Imaging at High Spatial and Temporal Resolution In Vitro and In Vivo

Cited by 1 publication

References 75 publications

Radiation Dose Enhancement Using Bi2S3 Nanoparticles in Cultured Mouse PC3 Prostate and B16 Melanoma Cells

Radiation Dose Enhancement Using Bi2S3 Nanoparticles in Cultured Mouse PC3 Prostate and B16 Melanoma Cells

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