Biomolecular logic devices based on stimuli-responsive PNIPAM-DNA film electrodes and bioelectrocatalysis of natural DNA with Ru(bpy)32+ as mediator

Graphene-PtPd nanocomposite for low-potential-driven electrochemiluminescent determination of carcinoembryonic antigen using Ru(bpy)32+

“…Carcinoembryonic antigen (CEA) is commonly used in clinical practice to discovery and assess cancers [1], and so far various strategies have been used to realize the sensitive detection of CEA such as electrochemical analysis [2], fluorescence immunoassay [3], photochemical analysis [4], and surface-enhanced Raman scattering [5]. Recently, electrochemiluminescence (ECL) analysis based on tris(2,2′bipyridine)ruthenium(ii) (Ru(bpy) 3 2+ ) or its derivative has attracted widespread attention in biosensor, because of its high ECL signal and electrochemical reversibility in an aqueous solution [6][7][8]. For instance, the ECL signal from Ru(bpy) 3 2+ at 1.15 V was recently used to construct a biomolecular logic circuits [6].…”

“…Recently, electrochemiluminescence (ECL) analysis based on tris(2,2′bipyridine)ruthenium(ii) (Ru(bpy) 3 2+ ) or its derivative has attracted widespread attention in biosensor, because of its high ECL signal and electrochemical reversibility in an aqueous solution [6][7][8]. For instance, the ECL signal from Ru(bpy) 3 2+ at 1.15 V was recently used to construct a biomolecular logic circuits [6]. Zhang et al firstly studied the ECL behavior of Ru(bpy) 3 2+ on Ti 3 C 2 Tx MXene adopting peroxydisulfate as coreactant, and an obvious ECL signal appeared at − 2.25 V (vs. Ag/AgCl) [7].…”

The Construction of Stimulus‐responsive Film Electrode by the Cu‐catalyzed Radical Polymerization and its Application in Multi‐valued Biologic Systems

“…The effective integration of the stimulus-responsive film and the electrode substrate directly affects the stability and complexity of logic calculations [15]. At present, the common methods for constructing film electrodes include radical polymerization [16,17] and atom transfer radical polymerization (ATRP) [18,19]. However, there are still some inevitable problems in the current construction process.…”

“…But, the interference between structures and properties of different polymer might affect the response output. Besides, some researches also reported that special materials are incorporated into polymer films to introduce other responsiveness, such as carbon quantum dots [22], Au nanoparticles [23], and metal ions [17] etc. However, the lack of compatibility between these materials and the polymers resulted in less stable and repeatable logic computing.…”

Construction of Multiple Switchable Sensors and Logic Gates Based on Carboxylated Multi-Walled Carbon Nanotubes/Poly(N,N-Diethylacrylamide)

“…Molecular logic gates, a type of logic gates system, can use biological materials or biomolecules such as enzymes, DNA, or proteins to establish basic or -simple molecular devices and equipment [ 3 , 4 , 5 , 6 , 7 ]. For example, Liu’s group successfully established 4-input/7-output biomolecular logic gates, and provided a new method to construct complex biomolecular logic gate system based on bio-electrocatalysis of natural DNA [ 8 ]. An adjustable electrocatalysis was constructed on the basis of multiple responsive interface poly ( N -isopropylacrylamide co- N , N ’-dimethylaminoethylmethacrylate) (P(NiPAAm-DMEM) films while the immobilization of glucose oxidase (GOD) and horseradish peroxidase (HRP) on the surface of pyrolytic graphite (PG) electrodes was also used to construct logic gates by Liu and coworkers [ 9 ].…”