Biomolecule-templated photochemical synthesis of silver nanoparticles: Multiple readouts of localized surface plasmon resonance for pattern recognition

Protein‐Induced Shape Control of Noble Metal Nanoparticles

“…The resulting nanoprisms have sharp edges, which can be controlled by the amount of silver nitrate concentration in the growth step. Pu et al have created protein protected silver nanoparticles by irradiating the solution mixture with UV light (Figure C) . Based on the absorption position, different proteins could be identified similar to the case of gold as mentioned above …”

“…The illustration is only a graphical presentation and does not show the real scale and conformation of each component. (C) Reproduced with permission . Copyright 2018, Springer GmbH.…”

Sequence-specific control of inorganic nanomaterials morphologies by biomolecules

“…They reported the relationships between the width of the interior plasmonic nanogap and surface-enhanced Raman scattering efficiencies. On the other hand, Pu et al [52] reported a protein-mediated synthesis of Ag nanoparticles that exhibited specific localized surface plasmon resonance (LSPR) for each protein used. This method involved multiple proteins that produced multiple readouts of LSPR signals of AgNPs to further construct sensor arrays for pattern recognition of proteins.…”

Establishing empirical design rules of nucleic acid templates for the synthesis of silver nanoclusters with tunable photoluminescence and functionalities towards targeted bioimaging applications

“…Due to the ease of sequence tunability and well-understood base-pairing properties, DNA molecules can be synthetically designed at high precision and produced at low cost, leading to diverse application of DNA in biomedicine (e.g., biomarkers for diseases diagnostics), materials science (e.g., self-assembled DNA origami), electronics (e.g., DNA logic gates), and computing. [1][2][3][4] More recently, the realization that biomolecules can also act as precursors (to form nanodots), [5][6][7][8][9][10] and capping or reducing agents for the coordination of metal cations has revolutionized the eld of bionanotechnology, 11,12 opening up new opportunities to produce exotic biohybrid nanomaterials such as DNA-assembled metal nanostructures, [13][14][15][16] DNA-/peptide-synthesized anisotropic metal nanoparticles, [17][18][19][20][21] protein-/peptide-templated ultrasmall metal nanoclusters, [22][23][24][25][26][27] and even nucleotide-derived nanodots (without metal precursors), 7 which inherit not only the biocompatibility and functionality of biomolecules, but also possess unique physiochemical properties of nanomaterials for a wide range of technological applications. 11,[28][29][30] Since the seminal work of using DNA molecules as stabilizers (or templates) to form photoluminescent silver nanoclusters (AgNCs) by Dickson and coworkers in 2004, 31 the fundamental study and applications of DNA-templated AgNCs (DNA-AgNCs) have witnessed dramatic advancements in recent years.…”