Biomolecules meet organic frameworks: from synthesis strategies to diverse applications

Li, Jing; Li, Chunyan; Zhao, Zelong; Guo, Yuxue; Chen, Hongli; Liu, Pai; Zhao, Meiting; Guo, Jun

doi:10.1039/d3nr05586h

Cited by 2 publications

(1 citation statement)

References 97 publications

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“…Biomolecules, such as γ-PGA, have diverse applications [ 50 ]. In addition to DNA, siRNA and mRNA can also be delivered using γ-PGA [ 51 , 52 , 53 ].…”

Section: Discussionmentioning

confidence: 99%

Interaction of γ-Polyglutamic Acid/Polyethyleneimine/Plasmid DNA Ternary Complexes with Serum Components Plays a Crucial Role in Transfection in Mice

Ko,

Fumoto,

Kurosaki

et al. 2024

Pharmaceutics

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Typical examples of non-viral vectors are binary complexes of plasmid DNA with cationic polymers such as polyethyleneimine (PEI). However, problems such as cytotoxicity and hemagglutination, owing to their positively charged surfaces, hinder their in vivo use. Coating binary complexes with anionic polymers, such as γ-polyglutamic acid (γ-PGA), can prevent cytotoxicity and hemagglutination. However, the role of interactions between these complexes and serum components in in vivo gene transfer remains unclear. In this study, we analyzed the contribution of serum components to in vivo gene transfer using PEI/plasmid DNA binary complexes and γ-PGA/PEI/plasmid DNA ternary complexes. In binary complexes, heat-labile components in the serum greatly contribute to the hepatic and splenic gene expression of the luciferase gene. In contrast, serum albumin and salts affected the hepatic and splenic gene expression in the ternary complexes. Changes in physicochemical characteristics, such as increased particle size and decreased absolute values of ζ-potential, might be involved in the enhanced gene expression. These findings would contribute to a better understanding of in vivo non-viral gene transfer using polymers, such as PEI and γ-PGA.

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“…Biomolecules, such as γ-PGA, have diverse applications [ 50 ]. In addition to DNA, siRNA and mRNA can also be delivered using γ-PGA [ 51 , 52 , 53 ].…”

Section: Discussionmentioning

confidence: 99%

Interaction of γ-Polyglutamic Acid/Polyethyleneimine/Plasmid DNA Ternary Complexes with Serum Components Plays a Crucial Role in Transfection in Mice

Ko,

Fumoto,

Kurosaki

et al. 2024

Pharmaceutics

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Harnessing Biomolecule-Infused 2D Multi-layered Luminescent Zn(II) Coordination Polymer for Electrochemical Energy Storage

Khan,

Shukla,

Bhattacharya

et al. 2024

Inorg. Chem.

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Selecting the right functional linkers and metal centers is crucial for creating multifunctional crystalline coordination polymers, which show promise in energy storage applications. Herein, a new two-dimensional Zn(II)-based CP, named BPHCC-1, has been synthesized using solvothermal methods with 2-amino terephthalic acid (2ATA) and the biomolecule purine as key building blocks. Purine, which is relatively unexplored in CP synthesis, plays a crucial role in the distinct properties of CPs. BPHCC-1, obtained as a stable crystalline solid, was characterized through various analytical techniques including Fourier transform infrared spectroscopy, field emission scanning electron microscope, transmission electron microscopy, X-ray diffraction, X-ray photoelectron spectroscopy, and Brunauer−Emmett−Teller analysis. The material's stability is attributed to extensive hydrogen bonding, π•••π interactions, and coordination of the −NH 2 group with the Zn(II) center. BPHCC-1 exhibits bright blue luminescence at 435 nm with a photoluminescence quantum yield of 29% in an aqueous dispersion. Furthermore, it demonstrates significant electrochemical energy storage performance, with a specific capacitance of 84 F g −1 at 3 A g −1 and retaining 64% of its original capacitance after 500 cycles. This study introduces a facile approach to designing multifunctional CPs, showcasing BPHCC-1's potential as a luminescent probe and pseudocapacitive supercapacitor. The findings highlight the versatility of BPHCC-1, suggesting broad opportunities for its use across diverse fields.

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Biomolecules meet organic frameworks: from synthesis strategies to diverse applications

Abstract: Biomolecules are essential in pharmaceuticals, biocatalysts, biomaterials, etc., but unfortunately are extremely susceptible to extraneous conditions. When biomolecules meet porous organic frameworks, significantly improved thermal, chemical, and mechanical stabilities are...

Cited by 2 publications

References 97 publications

Interaction of γ-Polyglutamic Acid/Polyethyleneimine/Plasmid DNA Ternary Complexes with Serum Components Plays a Crucial Role in Transfection in Mice

Interaction of γ-Polyglutamic Acid/Polyethyleneimine/Plasmid DNA Ternary Complexes with Serum Components Plays a Crucial Role in Transfection in Mice

Harnessing Biomolecule-Infused 2D Multi-layered Luminescent Zn(II) Coordination Polymer for Electrochemical Energy Storage

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