Biomonitoring of blood heavy metals and reproductive hormone level related to low semen quality

Li, Ching Jen; Yeh, Chien-Yuh; Chen, Ruey Yu; Tzeng, Chii Ruey; Han, Bor-Cheng; Chien, Ling-Chu

doi:10.1016/j.jhazmat.2015.08.027

Cited by 21 publications

(10 citation statements)

References 46 publications

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“…Furthermore, lead is considered an endocrine disruptor that can damage the semen quality (17,36). In our previous study, blood lead levels were significantly and negatively associated with semen quality, and high blood lead levels (>50 μg/l) had a 11-fold higher risk of low semen quality (17).…”

mentioning

confidence: 89%

Decline in Semen Quality in Men in Northern Taiwan between 2001 and 2010

Tzeng

Chen

et al. 2016

Chin. J. Physiol.

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Semen quality is a key indicator of the male reproductive ability. The decline in semen quality has been debated for several decades. However, data on decline in semen quality might be inconsistent given factors such as geographical area, ethnicity, environmental exposure and lifestyle changes. This study aimed to provide information on the semen quality of men in Northern Taiwanese. We recruited 7,187 male participants between 2001 and 2010 from a reproductive medical center. The age of the participants ranged from 26 to 57 years, with a mean age of 36.9 ± 4.77 years. Semen analysis was performed through standardized methods outlined in the World Health Organization laboratory manual. Increasing age (per year) was significantly and negatively associated with semen volume (1.006 ml), progressive sperm motility, rapid progressive sperm motility and sperm with normal morphology (reduction by 1.010%, 1.013% and 1.002% per year, respectively). In addition, sperm concentration, semen volume, number of sperms, progressive sperm motility, rapid progressive sperm motility, and sperm with normal morphology were significantly reduced annually by 1.013 × 10⁶/ml, 1.015 ml, 1.028 × 10⁶, 1.021 %, 1.017% and 1.016%, respectively). Age-period-cohort (APC) analyses revealed that age and cohort had effects on reduction of the progressive and rapid progressive sperm motility. Moreover, all the sperm parameter values were significantly reduced annually. Our findings provide useful information for clinical practice and public health investigations of male reproductive health.

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mentioning

confidence: 89%

Decline in Semen Quality in Men in Northern Taiwan between 2001 and 2010

Tzeng

Chen

et al. 2016

Chin. J. Physiol.

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“…Increased levels of lead in the seminal fluid had a negative impact on the quality of semen [13,24,31,40]. Similarly, in a Taiwanese study, increased levels of lead in the blood (> 50 μg/L) correlated with a low quality of semen [20]. In 2012, an interesting study was conducted on men with azoospermia and dark-coloured semen, in which platinum, lead, manganese and nickel were found.…”

Section: Impact Of Leadmentioning

confidence: 94%

“…The activity of CuZnSOD and MnSOD dismutases has been shown to be high in sperm cells, which correlates with their motility. It is important that MnSOD dismutase is mainly found in the mitochondrial matrix of sperm cells [20,21,22]. sód (300 mg/100 mL), potas (109 mg/100 mL), chlorki (142 mg/100 mL), wapń (27,6 mg/100 mL), magnez (11,0 mg/100 mL) oraz cynk (16,5 mg/100 mL) [11,12].…”

Section: The Role Of Zincmentioning

confidence: 99%

“…Wykazano, że w plemnikach aktywność dysmutazy CuZnSOD i dysmutazy MnSOD jest duża, co koreluje z ich ruchliwością. Istotne jest, że dysmutaza MnSOD występuje głównie w macierzy mitochondrialnej plemników [20,21,22].…”

Section: The Role Of Ironunclassified

“…Podwyższony poziom ołowiu w płynie nasiennym wpływał na spadek jakości nasienia [13,24,31,40]. Podobnie w tajwańskim badaniu -podwyższone poziomy ołowiu we krwi (> 50 μg/L) korelowały z niską jakością nasienia [20]. Ciekawemu badaniu poddano w 2012 r. mężczyzn z azoospermią i ciemno zabarwionym nasieniem, w którym wykazano obecność platyny, ołowiu, manganu i niklu.…”

Section: Wpływ Ołowiuunclassified

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The role of physiologically occurring elements in semen and effect of heavy metals on semen

Chyra-Jach

Kaletka

Kasperczyk

2020

Ann. Acad. Med. Siles.

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Na przestrzeni ostatnich 40 lat spadła jakość nasienia męskiego, w tym m.in. liczba plemników. U podstaw tego zjawiska leży wiele przyczyn, wśród których wymienia się ekspozycję zawodową i środowiskową na metale ciężkie, m.in. na kadm, ołów, rtęć i arsen. Duże znaczenie ma również zanieczyszczona mykotoksynami i pestycydami żywność, wpływ chemikaliów przemysłowych, palenie papierosów i czynniki endokrynologiczne. Niniejsza praca stanowi omówienie problemu na podstawie piśmiennictwa z ostatnich kilku lat na temat roli metali fizjologicznie występujących w nasieniu oraz wpływu metali ciężkich na obniżenie płodności męskiej.

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