Biomonitoring of occupational exposure to bisphenol A, bisphenol S and bisphenol F: A systematic review

Bousoumah, Radia; Leso, Veruscka; Iavicoli, Ivo; Huuskonen, Pasi; Viegas, Susana; Porras, Simo P.; Santonen, Tiina; Fréry, Nadine; Robert, Alain; Ndaw, Sophie

doi:10.1016/j.scitotenv.2021.146905

Cited by 126 publications

(51 citation statements)

References 50 publications

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“…Regarding occupational exposure to BPA, HBM data are more limited and those identified in a review published by Bousoumah et al (2021) from five European occupational studies are discussed for risk assessment purposes [ 31 ]. A Finnish study by Heinälä et al published in 2017 and involving 49 workers was conducted in five different companies using BPA in the production of paints, composites, tractors and thermal papers [ 35 ].…”

Section: Resultsmentioning

confidence: 99%

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Human Biomonitoring Guidance Values (HBM-GVs) for Bisphenol S and Assessment of the Risk Due to the Exposure to Bisphenols A and S, in Europe

Meslin

Beausoleil

Zeman

et al. 2022

Toxics

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Within the European Joint Programme HBM4EU, Human Biomonitoring Guidance Values (HBM-GVs) were derived for several prioritised substances. In this paper, the derivation of HBM-GVs for the general population (HBM-GVGenPop) and workers (HBM-GVworker) referring to bisphenol S (BPS) is presented. For the general population, this resulted in an estimation of the total urinary concentration of BPS of 1.0 µg/L assuming a 24 h continuous exposure to BPS. For workers, the modelling was refined in order to reflect continuous exposure during the working day, leading to a total urinary concentration of BPS of 3.0 µg/L. The usefulness for risk assessment of the HBM-GVs derived for BPS and bisphenol A (BPA) is illustrated. Risk Characterisation Ratios (RCRs) were calculated leading to a clear difference between risk assessments performed for both bisphenols, with a very low RCR regarding exposure to BPA., contrary to that obtained for BPS. This may be due to the endocrine mediated endpoints selected to derive the HBM-GVs for BPS, whereas the values calculated for BPA are based on the temporary Tolerable Daily Intake (t-TDI) from EFSA set in 2015. A comparison with the revised TDI recently opened for comments by EFSA is also discussed. Regarding the occupational field, results indicate that the risk from occupational exposure to both bisphenols cannot be disregarded.

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Section: Resultsmentioning

confidence: 99%

“…To respect data ownership, only results published in the literature were used in this paper. To document BPA exposure for the occupational population, data from occupational studies included in the review from Bousoumah et al (2021) [ 31 ] were also used.…”

Section: Methodsmentioning

confidence: 99%

Human Biomonitoring Guidance Values (HBM-GVs) for Bisphenol S and Assessment of the Risk Due to the Exposure to Bisphenols A and S, in Europe

Meslin

Beausoleil

Zeman

et al. 2022

Toxics

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“…To date, BPA is one of the world's highest volume-produced chemical compounds. Global production of this endocrine-disrupting compound reached 7.7 million tonnes in 2015 and is expected to exceed 10.6 million in 2022 (Bousoumah et al 2021;Catenza et al 2021;Ohore and Zhang 2021). Due to the widespread use of BPA in many consumer products, it can migrate into the environment mainly through leaching from BPA-based materials (Bhatnagar and Anastopoulos 2017;Bjornsdotter et al 2017).…”

Section: Introductionmentioning

confidence: 99%

Toxicity of bisphenol A and its structural congeners to microalgae Chlorella vulgaris and Desmodesmus armatus

Krawczyk

Szczukocki

2022

J Appl Phycol

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Bisphenol A and its structural congeners are increasingly recognized as emerging contaminants with toxic and estrogenic potential that have been widely used in many consumer products. Due to their widespread occurrence in aquatic environment, they could pose risks to the primary producers, such as microalgae. Therefore, the objective of this study was to examine the toxicity of bisphenol A, its six structural congeners, and their mixture towards the green algae Chlorella vulgaris and Desmodesmus armatus. Bisphenol A (average 14 days, EC50: 42.29 mg L−1) exhibited less harmful effect than structural congeners, such as bisphenol AF, bisphenol G, bisphenol X for C. vulgaris (average 14 days, EC50: 22.39 mg L−1) and bisphenol AF, bisphenol G, bisphenol M, bisphenol X for D. armatus (average 14 days, EC50: 27.16 mg L−1), respectively. Moreover, exposure to combined bisphenol A and its structural congeners leads to synergistic effects. Thus, the increased adverse effect caused by complex chemical mixture poses a greater risk to microalgae. The order of toxic effect (14 days, EC50) of individual and combined structural congeners was: bisphenol G > bisphenol X > mixture > bisphenol AF > bisphenol A > bisphenol Y > bisphenol M > bisphenol P for C. vulgaris and mixture > bisphenol G > bisphenol X > bisphenol M > bisphenol AF > bisphenol A > bisphenol Y > bisphenol P for D. armatus, respectively. This is the first time that the toxicity of structural congeners of bisphenol A and its mixture to microalgae is described. Furthermore, these results were conducted to assess potential ecological risk of these compounds in the aquatic environment.

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“…Unfortunately, these substitutes have physicochemical properties similar to those of BPA and, for some of them, relevant endocrine-disrupting activity has been proven [ 9 , 10 , 11 , 12 , 13 ]. There are many human exposure routes for BPA and EDCs in general, including occupational exposure, the ingestion of contaminated food, inhalation, and dermal absorption from the environment [ 14 , 15 , 16 , 17 ]. In 2015, the European Food Safety Authority (EFSA) published a scientific opinion about the risk to human health posed by the occurrence of BPA in foodstuffs [ 18 ]; although it was found that BPA intake via diet does not represent a risk to human health, the panel identified food as the main source of intake.…”

Section: Introductionmentioning

confidence: 99%

Determination of 20 Endocrine-Disrupting Compounds in the Buffalo Milk Production Chain and Commercial Bovine Milk by UHPLC–MS/MS and HPLC–FLD

Pisciottano

Guadagnuolo

Busico

et al. 2022

Animals

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Bisphenol A (BPA) and some of its analogues are well known as endocrine-disrupting chemicals (EDCs), i.e., compounds that can affect the physiological hormonal pathways in both animals and humans, causing adverse health effects. The intake of these substances through diet represents a public concern, compounded by the scarce data in the literature about contamination levels in food. In the framework of a research project, funded by the Italian Ministry of Health, we determined the contamination levels of BPA and 19 EDCs in the production chain of buffalo milk, analysing feed, drinking water, buffalo milk, and blood sera. Overall, 201 feed, 9 feed additive, 62 drinking water, 46 milk, and 190 blood serum samples were collected from 10 buffalo farms in the Campania region, Southern Italy, between 2019 and 2020, and analysed. Moreover, 15 retail bovine milk samples packaged both in Tetra Pak and in PET were analysed to further evaluate consumers’ exposure to EDCs. The results of our work showed no contamination by EDCs in drinking water samples, whereas in 43% of all of the other samples from the farms at least one bisphenol was detected. The most abundant bisphenol detected was BPA (32% of the samples from the farms and 80% of the retail milk samples), thus proving that this compound is still widely used for plastic production.

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Biomonitoring of occupational exposure to bisphenol A, bisphenol S and bisphenol F: A systematic review

Cited by 126 publications

References 50 publications

Human Biomonitoring Guidance Values (HBM-GVs) for Bisphenol S and Assessment of the Risk Due to the Exposure to Bisphenols A and S, in Europe

Human Biomonitoring Guidance Values (HBM-GVs) for Bisphenol S and Assessment of the Risk Due to the Exposure to Bisphenols A and S, in Europe

Toxicity of bisphenol A and its structural congeners to microalgae Chlorella vulgaris and Desmodesmus armatus

Determination of 20 Endocrine-Disrupting Compounds in the Buffalo Milk Production Chain and Commercial Bovine Milk by UHPLC–MS/MS and HPLC–FLD

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