Biomonitoring of organochlorines, glutathione, lipid peroxidation and cholinesterase activity among pesticide sprayers in mango orchards

Singh, Jyoti; Kumari, Jyoti; Reddy, M. Mutha; Kesavachandran, Chandrasekharan Nair; Rastogi, Shivani; Siddiqui, M.K.J.

doi:10.1016/j.cca.2006.08.037

Cited by 49 publications

(24 citation statements)

References 30 publications

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“…Our findings support a significant positive correlation between working history and clinical symptoms in pesticide sprayers found by Singh et al (39) in organ systems such as the respiratory, ocular, gastrointestinal, and skin. Our farmers also complained of pesticide poisoning symptoms.…”

Section: Discussionsupporting

confidence: 92%

Neurocognitive, Mental Health, and Glucose Disorders in Farmers Exposed to Organophosphorus Pesticides

Malekirad

Faghih

Mirabdollahi

et al. 2013

Archives of Industrial Hygiene and Toxicology

105

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About 25 million agricultural workers in the developing world suffer from at least one episode of poisoning each year, mainly by anticholinesterase-like organophosphates (OPs). The objective of this cross-sectional study was to establish the OP toxicity in 187 occupationally exposed farmers in terms of neurocognitive impairment, mental health status, clinical symptoms, diabetes, and haematological factors. The exposed group was compared to 187 healthy age-, sex-, and education-matching controls. Neurocognitive impairment was measured using the Subjective Neurocognition Inventory (SNI) and mental health status using the General Health Questionnaire-28 (GHQ-28). The subjects were also tested for fasting blood glucose (FBG), blood urea nitrogen (BUN), cholesterol (CL), triglycerides (TG), creatinine, oral glucose tolerance test (GTT), high-density lipoprotein (HDL), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP). The exposed farmers showed higher FBG (p<0.001), BUN (p=0.007), CL (p<0.001), oral GTT (p<0.001), and lower AST (p<0.001), ALP (p<0.001), and creatinine (p=0.004) than controls. The rates of anxiety/ insomnia and severe depression were also signifi cantly higher in the farmers than in controls (p=0.015 and p<0.001, respectively). Meanwhile, the rate of social dysfunction was signifi cantly lower than in controls (p<0.001). Disorders affecting psychomotor speed, selective attention, divided attention, verbal memory, nonverbal memory, prospective memory, spatial functioning, and initiative/energy were all lower in the farmers (p<0.001). Farmers showed clinical symptoms eczema, saliva secretion, fatigue, headache, sweating, abdominal pain, nausea, superior distal muscle weakness, inferior distal muscle weakness, inferior proximal muscle weakness, breath muscle weakness, hand tingling, foot tingling, epiphoria, polyuria, miosis, dyspnoea, bradycardia, and rhinorrhoea, which all signifi cantly correlated with the number of working years. These fi ndings indicate that farmers who work with OPs are prone to neuropsychological disorders and diabetes.

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Section: Discussionsupporting

confidence: 92%

Neurocognitive, Mental Health, and Glucose Disorders in Farmers Exposed to Organophosphorus Pesticides

Malekirad

Faghih

Mirabdollahi

et al. 2013

Archives of Industrial Hygiene and Toxicology

105

View full text Add to dashboard Cite

show abstract

“…Our study revealed a significant rise in Plasma malondialdehyde (MDA) levels in exposed farmers than in controls. The results of our study were consistent with other studies suggesting that pesticides increase oxidative stress in humans (Prakasam et al 2001;Singh et al, 2007). There is increasing evidence that OP and carbamate induced oxidative stress through the generation of free oxygen radicals, leading to lipid peroxidation and DNA damage (Hazarika et al, 2003;Abdollahi et al, 2004;Vidyasagar et al, 2004;Shadnia et al, 2005).…”

Section: Oxidative Stresssupporting

confidence: 92%

Adverse Health Effects of Pesticides Exposure in Agricultural and Industrial Workers of Developing Country

Hashmi¹,

Imran²,

Dilshad³

2011

Pesticides - The Impacts of Pesticides Exposure

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“…These results further suggest that in spite of elevated SOD activity the system is overcome with ROS and GSH levels decline as conjugation reactions of GSH with toxicants supersede the cells ability to regenerate it again [62]. Previous studies also revealed that PAHs show a dose dependently enhanced production of superoxide ions [63].…”

Section: Variablesmentioning

confidence: 86%

Blood levels of polycyclic aromatic hydrocarbons in children and their association with oxidative stress indices: An Indian perspective

Singh

Patel

Kumari

et al. 2008

Clinical Biochemistry

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Biomonitoring of organochlorines, glutathione, lipid peroxidation and cholinesterase activity among pesticide sprayers in mango orchards

Cited by 49 publications

References 30 publications

Neurocognitive, Mental Health, and Glucose Disorders in Farmers Exposed to Organophosphorus Pesticides

Neurocognitive, Mental Health, and Glucose Disorders in Farmers Exposed to Organophosphorus Pesticides

Adverse Health Effects of Pesticides Exposure in Agricultural and Industrial Workers of Developing Country

Blood levels of polycyclic aromatic hydrocarbons in children and their association with oxidative stress indices: An Indian perspective

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