Biomonitoring of organochlorines in women with benign and malignant breast disease

Siddiqui, M.K.J.; Anand, Madhu; Mehrotra, P.; Sarangi, Rathindra; Mathur, Neeraj

doi:10.1016/j.envres.2004.07.015

Cited by 48 publications

(24 citation statements)

References 19 publications

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“…Extensive studies focused on the levels of organochlorine pesticides determined in serum did not support the hypothesis that organochlorines increase breast cancer risk [38,43,[86][87][88][89][90]. An association between adipose tissue levels of organochlorine pesticides (DDT, DDE) and breast cancer risk was also not estimated [91][92][93]. Similar results, i.e.…”

Section: Organochlorine Pesticidessupporting

confidence: 58%

Impact of Environmental Contaminants on Breast Cancer / Wpływ Zanieczyszczenia Środowiska Na Raka Piersi

Kráľová

Jampílek

2015

Ecological Chemistry and Engineering S

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Breast cancer is the most frequent cancer in women. It is believed that among the causes of breast cancer, hereditary factors account for only 5-10% of risk and the environmental exposures to environmental contaminants account for an additional 30-50% of risk. This paper summarizes findings related to the risk of breast cancer due to exposure to following environmental contaminants: polycyclic aromatic hydrocarbons, polychlorinated biphenyls and dioxins, organochlorine pesticides, organophosphorous pesticides, bisphenol A, phthalates, parabens, organic solvents, atmospheric pollutants, alkylphenols, metals, ionizing radiation, electromagnetic field and light pollution. Results obtained in in vitro experiments with breast cancer cell lines and in vivo with model rodents as well as in population based case-control studies are presented and the mode of action of individual environmental contaminants on mammary gland is discussed. Attention is also devoted to the effects of the timing of exposure to environmental contaminants (mainly exposition during development of the mammary gland) on breast cancer risk. Outcomes of professional exposure to some environmental contaminants on breast cancer risk are analysed as well.

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Section: Organochlorine Pesticidessupporting

confidence: 58%

Impact of Environmental Contaminants on Breast Cancer / Wpływ Zanieczyszczenia Środowiska Na Raka Piersi

Kráľová

Jampílek

2015

Ecological Chemistry and Engineering S

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“…The association of breast cancer risk with the specific serum levels of o,p 0 -DDT, p,p 0 -DDT, or p,p 0 -DDE was not always consistent, but in some analyses showed similar patterns owing to the correlation of their serum concentrations (Spearman correlation coefficient among controls = 0.57-0.86). Further, no previous study with a small sample size has found an increased risk of breast cancer in relation to o,p 0 -DDT exposure [17,25]. In addition, the lack of association with p,p 0 -DDT is consistent with the majority of previous studies [17,20,[25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40], including three nested case-control studies [26][27][28], whereas other studies found significant or marginal inverse [41,42] or positive [43][44][45][46][47] associations.…”

Section: Discussionmentioning

confidence: 89%

“…Indeed, the possibility that differences in background, such as in lifestyle, internal hormonal milieu, body burden of organochlorines, and hormone-receptor subtypes, might influence the associations have now made race, ethnicity, and area specificity issues in this field. In recent years, three studies have assessed the association between breast cancer and organochlorines in AfricanAmerican women [14][15][16], one of which also included Asian subjects (50 pairs) [15], but all reported null results; and apart from one small study in India (25 pairs), no study has yet been conducted in an Asian country, including Japan [17].…”

Section: Introductionmentioning

confidence: 99%

Serum organochlorines and breast cancer risk in Japanese women: a case–control study

Itoh¹,

Iwasaki²,

Hanaoka³

et al. 2008

Cancer Causes Control

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“…In our current review, we update the literature since 2002. We identified 11 published studies 32,[162][163][164][165][166][167][168][169][170][171] that reported on associations between measured serum, plasma, or adipose tissue concentrations of OC insecticides and breast cancer, which were not included in either the review by Calle et al or Lopez-Cervantes et al 160,161 Two studies 162,167 were excluded from our review because risk estimates (eg, ORs) were not reported. A third study 32 was excluded because the case definition included prevalent breast cancer.…”

Section: Nonoccupational Oc Insecticide Exposure and Breast Cancermentioning

confidence: 99%

Increased cancer burden among pesticide applicators and others due to pesticide exposure

Alavanja

Ross

Bonner

2013

CA A Cancer J Clinicians

296

213

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A growing number of well-designed epidemiological and molecular studies provide substantial evidence that the pesticides used in agricultural, commercial, and home and garden applications are associated with excess cancer risk. This risk is associated both with those applying the pesticide and, under some conditions, those who are simply bystanders to the application. In this article, the epidemiological, molecular biology, and toxicological evidence emerging from recent literature assessing the link between specific pesticides and several cancers including prostate cancer, non-Hodgkin lymphoma, leukemia, multiple myeloma, and breast cancer are integrated. Although the review is not exhaustive in its scope or depth, the literature does strongly suggest that the public health problem is real. If we are to avoid the introduction of harmful chemicals into the environment in the future, the integrated efforts of molecular biology, pesticide toxicology, and epidemiology are needed to help identify the human carcinogens and thereby improve our understanding of human carcinogenicity and reduce cancer risk. CA Cancer J Clin 2013;63:120-142.

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Biomonitoring of organochlorines in women with benign and malignant breast disease

Cited by 48 publications

References 19 publications

Impact of Environmental Contaminants on Breast Cancer / Wpływ Zanieczyszczenia Środowiska Na Raka Piersi

Impact of Environmental Contaminants on Breast Cancer / Wpływ Zanieczyszczenia Środowiska Na Raka Piersi

Serum organochlorines and breast cancer risk in Japanese women: a case–control study

Increased cancer burden among pesticide applicators and others due to pesticide exposure

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