Biomonitoring of two types of chromium exposure in an electroplating shop

Fontaine, P.; Diebold, F.; Baruthio, F

doi:10.1007/s00420-007-0216-x

Cited by 18 publications

(6 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1,2,18 Cr-U at ES closely correlated with Cr-P, which in turn correlated with Cr-RBC, whereas the correlation between Cr-U and Cr-RBC was not significant. Despite the expected differences due to the type of exposure, 35 these data are in line with those recently found by Scheepers et al (2008), who observed that Cr-P in welders exposed to low levels of Cr(III) and Cr(VI) closely correlated with Cr-U at both BS and ES, and that the correlation between Cr-RBC and Cr-U was significant, although the correlation coefficient was lower. 36 On the other hand, the correlation between Cr-P and Cr-U/Cr-RBC was lost in BS samples, in which only the correlation between Cr-U and Cr-RBC was highly significant.…”

Section: Discussionsupporting

confidence: 91%

Chromium in exhaled breath condensate (EBC), erythrocytes, plasma and urine in the biomonitoring of chrome-plating workers exposed to soluble Cr(vi)

et al. 2010

View full text Add to dashboard Cite

Chromium (Cr) levels measured in exhaled breath condensate (EBC-Cr) and urine (Cr-U) at the beginning and end of working shifts were related to those measured in erythrocytes (Cr-RBC) and plasma in 14 non-smoking male chrome-plating workers exposed to Cr(VI) in soluble aerosol form who did not report any significant current or past respiratory disease. Cr-U mainly correlated with Cr-P (Cr in plasma) at the end of the working shift (r(2) = 0.59, p < 0.01), whereas Cr-RBC correlated with EBC-Cr (r(2) = 0.32, p < 0.05); at the beginning of the shift, the only significant correlation was between Cr-U and Cr-RBC (r(2) = 0.74, p < 0.01). The clearance of Cr(iii) arising from Cr(VI) reduction was rapid, thus making Cr-U and Cr-P ideal biomarkers of the most recent exposure, whereas Cr-RBC may represent the fraction of Cr(VI) that reaches the bloodstream in non-reduced form and therefore depends on the airway inhaled dose represented by EBC-Cr. Cr-RBC clearance is slower and not only involves the free diffusion of Cr(iii) from RBC to plasma, but probably also involves more complicated kinetic phenomena involving other tissues and organs, which may explain the correlation between Cr-RBC and Cr-U and the lack of correlation Cr-RBC and Cr-P at least 36 h after the last exposure. In conclusion, our findings reinforce the idea that measuring Cr in EBC can significantly contribute to traditional biomonitoring by providing specific information at the target organ level and integrating our knowledge of Cr toxicokinetics.

show abstract

Section: Discussionsupporting

confidence: 91%

Chromium in exhaled breath condensate (EBC), erythrocytes, plasma and urine in the biomonitoring of chrome-plating workers exposed to soluble Cr(vi)

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Previous studies of electroplating workers have often reported poor/no correlations between air and urine metal concentrations 18-20 , although some studies have observed moderate to high correlations (range: r = 0.48–0.96, median: r = 0.68) 21-24 . The relationship between air and urinary measurements likely varies due to the extent of dermal exposure, the use of personal protective equipment, and personal behaviors such as smoking that may transfer the contaminants from hand to mouth, as well as the time of day the urinary measurements are collected in relation to the air measurements 21-22, 25-26 .…”

Section: Introductionmentioning

confidence: 97%

Reliability and validity of expert assessment based on airborne and urinary measures of nickel and chromium exposure in the electroplating industry

Chen

Coble

Deziel

et al. 2014

J Expo Sci Environ Epidemiol

View full text Add to dashboard Cite

The reliability and validity of six experts’ exposure ratings were evaluated for 64 nickel-exposed and 72 chromium-exposed workers from six Shanghai electroplating plants based on airborne and urinary nickel and chromium measurements. Three industrial hygienists and three occupational physicians independently ranked the exposure intensity of each metal on an ordinal scale (1–4) for each worker's job in two rounds: the first round was based on responses to an occupational history questionnaire and the second round also included responses to an electroplating industry-specific questionnaire. Spearman correlation (rs) was used to compare each rating's validity to its corresponding subject-specific arithmetic mean of four airborne or four urinary measurements. Reliability was moderately-high (weighted kappa range=0.60–0.64). Validity was poor to moderate (rs= -0.37–0.46) for both airborne and urinary concentrations of both metals. For airborne nickel concentrations, validity differed by plant. For dichotomized metrics, sensitivity and specificity were higher based on urinary measurements (47–78%) than airborne measurements (16–50%). Few patterns were observed by metal, assessment round, or expert type. These results suggest that, for electroplating exposures, experts can achieve moderately-high agreement and (reasonably) distinguish between low and high exposures when reviewing responses to in-depth questionnaires used in population-based case-control studies.

show abstract

“…(96) As already mentioned, Pierre et al (1998) studied the individual exposure and plasma and urine levels of aluminium for 335 workers from seven aluminium industry plants. Detailed air and urine data are provided for six individuals monitored over 1 week (Table 6.4).…”

Section: Ingested Materials ômentioning

confidence: 99%